Alleviation of lipid metabolic dysfunction through regulation of intestinal bacteriophages and bacteria by green tea polyphenols in Ob/Ob mice

Food Chemistry, Год журнала: 2024, Номер 456, С. 139988 - 139988

Опубликована: Июнь 5, 2024

Язык: Английский

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Roles of Lysine Methylation in Glucose and Lipid Metabolism: Functions, Regulatory Mechanisms, and Therapeutic Implications

Biomolecules, Год журнала: 2024, Номер 14(7), С. 862 - 862

Опубликована: Июль 19, 2024

Glucose and lipid metabolism are essential energy sources for the body. Dysregulation in these metabolic pathways is a significant risk factor numerous acute chronic diseases, including type 2 diabetes (T2DM), Alzheimer’s disease (AD), obesity, cancer. Post-translational modifications (PTMs), which regulate protein structure, localization, function, activity, play crucial role managing cellular glucose metabolism. Among PTMs, lysine methylation stands out as key dynamic modification vital epigenetic regulation of gene transcription. Emerging evidence indicates that significantly impacts by modifying enzymes proteins. This review summarizes current understanding methylation’s regulatory mechanisms We highlight involvement methyltransferases (KMTs) demethylases (KDMs) generating abnormal signals affecting pathways. Additionally, we discuss chemical biology pharmacology KMT KDM inhibitors targeted degraders, emphasizing their clinical implications diseases such diabetes, neurodegenerative disorders, cancers. suggests targeting could be an ideal therapeutic strategy treating diseases.

Язык: Английский

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Exercise-promoted adiponectin secretion activates autolysosomes to protect the liver of ApoE^−/− mice from a high-fat diet

Food & Function, Год журнала: 2024, Номер 15(19), С. 9796 - 9812

Опубликована: Янв. 1, 2024

Treadmill exercise promotes liver fat uptake, activates lipolysis and inhibits DNL, autolysosomes through APN-AdipoR1 to accelerate protect hepatocytes from lipotoxicity.

Язык: Английский

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Changes in the Expression of Inflammatory Genes Induced by Chronic Exercise in the Adipose Tissue: Differences by Sex

Sports, Год журнала: 2024, Номер 12(7), С. 184 - 184

Опубликована: Июль 1, 2024

The impact of obesity on adipose tissue function is well acknowledged, but the role physical exercise in regulating inflammatory markers and gene expression obese individuals remains uncertain. This study aims to investigate effects chronic explore sex differences response exercise. involved 29 participants (13 men, 16 women) aged 38 54 years with a mean BMI 36.05 ± 4.99 kg/m

Язык: Английский

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Capsinoids Promotes an Increase in Enzyme Antioxidative Activity and Prevents the Injury Cardiac Induced by Obesity without Positively Modulate the Cardiac Oxidative Biomarkers

Опубликована: Июль 24, 2024

Capsinoids (CAP) are potential antioxidant agents capable of reducing oxidative damage and the resulting complications triggered by obesity. Thus, aim this study was to investigate effects CAP on adiposity biomarkers cardiac stress in rats with obesity induced a high-fat diet. Male Wistar were exposed diet for 27 consecutive weeks. After characterization (week 19), some obese (Ob) animals began receive capsinoids (10 mg/kg/day) orogastric gavage. Adiposity comorbidities assessed. In heart, remodeling, injury determinated. The treatment did not reduce d obesity, but they efficient cholesterol levels. cause difference heart LV mass, despite having reduced troponin I concentrations. Furthermore, capisinoids increase advanced oxidation proteins products (AOPP) carbonylated (CBO) caused tissue. Besides that, it observed that ObCap presented high levels malondialdehyde greater activity enzymes compared Ob. conclusion, lead significant positive obesity-induced stress.

Язык: Английский

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Immune regulation and organ damage link adiponectin to sepsis

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 27, 2024

Sepsis is a life-threatening syndrome characterized by organ dysfunction, resulting from an uncontrolled or abnormal immune response to infection, which leads septicemia. It involves disruption of homeostasis, marked the release Inflammatory factors and dysfunction cells. Adiponectin widely recognized as anti-inflammatory mediator, playing crucial role in regulating cell function exerting protective effects on tissues organs. However, physiological adiponectin septicemia remains unclear due condition's association with dysregulation damage. This study focuses potential relationship between excessive responses, along injury Additionally, we investigate possible explanations for observed discrepancies levels among critically ill deceased patients compared theoretical expectations, aiming provide valuable insights clinical diagnostics therapeutic interventions sepsis.

Язык: Английский

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Adiponectin orchestrates testosterone suppression in biological pathways

Asian Pacific Journal of Reproduction, Год журнала: 2024, Номер 13(2), С. 52 - 59

Опубликована: Март 1, 2024

This current review highlights adiponectin engagement with AdipoRl and AdipoR2 which subsequently triggers pathways such as AMPK, PPARα, MAPK, thereby modulating testicular steroidogenesis. Adiponectin's actions on Leydig adrenal cells inhibit androgen secretion by suppressing the steroidogenic acute regulatory protein (StAR). Given that StAR facilitates cholesterol to testosterone conversion, AMPK inhibits this process transport expression through multiple avenues. Furthermore, adiponectin-induced PPARα activation impedes mitochondrial influx, further biosynthesis. The suppressive influence of genes, notably StAR, is evident. Collectively, signalling predominantly attenuates production, ensuring metabolic reproductive equilibrium. Imbalances, seen in conditions like hypogonadism obesity-related infertility, highlight their crucial roles potential clinical interventions for disorders.

Язык: Английский

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Capsinoids Increase Antioxidative Enzyme Activity and Prevent Obesity-Induced Cardiac Injury without Positively Modulating Body Fat Accumulation and Cardiac Oxidative Biomarkers

Nutrients, Год журнала: 2024, Номер 16(18), С. 3183 - 3183

Опубликована: Сен. 20, 2024

Background/Objectives: Capsinoids are potential antioxidant agents capable of reducing oxidative damage and the resulting complications triggered by obesity. Thus, this study aimed to investigate effects capsinoids on adiposity biomarkers cardiac stress in obese rats induced a high-fat diet. Methods: Male Wistar were exposed diet for 27 consecutive weeks. After characterization obesity (week 19), some animals began receive (10 mg/kg/day) orogastric gavage. Adiposity comorbidities assessed. In heart, remodeling, injury, determined. Results: The treatment did not reduce obesity-induced but was efficient cholesterol levels. Capsinoid cause difference heart LV mass, despite having reduced troponin I concentrations. Furthermore, increase advanced oxidation protein products carbonylated proteins caused tissue. addition, treated with presented high levels malondialdehyde greater enzyme activity compared untreated rats. Conclusions: conclusion, increases antioxidative prevents injury without positively modulating body fat accumulation biomarkers.

Язык: Английский

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A cost-effective and sensitive Au/6-mercaptohexanol/CNBr modified immunosensor approach for adiponectin analysis

Microchemical Journal, Год журнала: 2024, Номер unknown, С. 112221 - 112221

Опубликована: Ноя. 1, 2024

Язык: Английский

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