Association of the systemic immune-inflammation index with all-cause and cardiovascular mortality in individuals with rheumatoid arthritis

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июль 2, 2024

Abstract The systemic immune-inflammation index (SII), a metric reflecting inflammatory response and immune activation, remains underexplored concerning its correlation with mortality among rheumatoid arthritis (RA) patients. This study aimed to delineate the association between SII both all-cause cardiovascular within cohort of American adults diagnosed RA, utilizing data from National Health Nutrition Examination Survey (NHANES) spanning 1999 2018. investigation extracted NHANES cycles 2018, identifying RA patients through questionnaire responses. was computed based on complete blood counts, employing formula: (platelets × neutrophils) / lymphocytes. optimal cutoff value for significant survival outcomes determined using maximally selected rank statistics. Multivariable Cox proportional hazards models assessed relationship levels (all-cause cardiovascular) patients, subgroup analyses examining potential modifications by clinical confounders. Additionally, restricted cubic spline (RCS) were conducted explore linearity SII-mortality association. encompassed 2070 whom 287 exhibited higher (≥ 919.75) 1783 lower (< 919.75). Over median follow-up duration 108 months, 602 participants died. After adjustments demographic, socioeconomic, lifestyle variables, associated 1.48-fold increased risk (hazard ratio [HR] = 1.48, 95% confidence interval [CI] 1.21–1.81, P < 0.001) 1.51-fold (HR 1.51, CI 1.04–2.18, 0.030) compared SII. Kaplan–Meier corroborated significantly reduced rates ( 0.0001 0.0004). RCS confirmed positive nonlinear rates. In conclusion, offers straightforward indicator equilibrium detrimental innate inflammation beneficial adaptive immunity. Our investigation, comprehensive nationally representative sample, reveals that elevated independently forecast greater all causes, as well cardiovascular-specific mortality, in individuals suffering RA. These insights underscore relevance an affordable readily accessible biomarker. Its incorporation into regular practice could enhance precision assessment forecasting facilitating more tailored effective management strategies. Specifically, high be identified stringent management, including closer monitoring, interventions, aggressive pharmacological treatments mitigate their mortality.

Язык: Английский

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Systemic inflammatory response index improves prognostic predictive value in intensive care unit patients with sepsis

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 14, 2025

Sepsis is a severe infectious disease with high mortality. However, the indicators used to evaluate its severity and prognosis are relatively complicated. The systemic inflammatory response index (SIRI), new indicator, has shown good predictive value in chronic infection, stroke, cancer. purpose of this study was investigate connection between sepsis SIRI usefulness. A total 401 patients were included study. Multiple linear regression logistic analyses performed relationship sepsis. restricted cubic spline (RCS) method employed illustrate dose-response relationship. area under curve (AUC) decision analysis (DCA) prognostic SIRI. revealed significant positive correlation both blood cell count Sequential Organ Failure Assessment (SOFA) score. Additionally, higher levels significantly linked risk worsening, according analysis. RCS demonstrated that poor rose increasing SIRI, particularly when exceeded 6.1. Furthermore, AUC DCA results showed had superior compared traditional indicators. worse more may serve as novel indicator sepsis, though further clinical studies necessary confirm these findings.

Язык: Английский

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Inflammatory indices—Systemic Immune-Inflammation Index (SII) and Systemic Inflammatory Response Index (SIRI)—during Pregnancy and Associations with Gestational Diabetes Mellitus

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 6521 - 6532

Опубликована: Сен. 1, 2024

Gestational diabetes mellitus (GDM) is a prevalent complication during pregnancy. This study aimed to explore the associations between inflammatory indices pregnancy and development of GDM.

Язык: Английский

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Screening significance of systemic immune‐inflammation index (SII) and systemic inflammation response index (SIRI) in coronary heart disease of symptomatic youth

Immunity Inflammation and Disease, Год журнала: 2024, Номер 12(8)

Опубликована: Авг. 1, 2024

The incidence of coronary heart disease (CHD) in youth is rapidly increasing but difficultly recognized the early stage.

Язык: Английский

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Systemic inflammation response index association with gout in hyperuricemic adults: NHANES 2007–2018

Frontiers in Medicine, Год журнала: 2025, Номер 11

Опубликована: Янв. 7, 2025

Hyperuricemia is the underlying condition of gout. Previous studies have indicated that specific strategies may be effective in preventing progression hyperuricemia to However, there a lack widely applicable methods for identifying high-risk populations Gout linked inflammation, especially hyperuricemic population. Systemic inflammation response index (SIRI) novel method evaluating an individual's systemic inflammatory activity. association between SIRI and gout population has not been studied. The study utilized data from National Health Nutrition Examination Survey (NHANES) 2007-2018.SIRI was log2-transformed before analysis. Multivariable logistic regression, subgroup analysis, smooth curve fitting were employed comprehensively evaluate correlation prevalence Additionally, we compared with other markers. A total 6,732 patients included, which 3,764 men. After adjusting all covariates, found significantly positively correlated female group ([OR = 1.385, 95% CI (1.187, 1.615), p < 0.001]), its diagnostic performance superior In male group, log2-SIRI significant 0.994, (0.892, 1.108), 0.916]). But positive correlations 20-45 age 1.362, (1.021, 1.818), 0.036]). Subgroup analyses revealed results largely consistent when individuals divided into different subgroups (FDR adjusted interaction >0.05 all). Our suggests Inflammation Response Index potential as predictive marker risk women. given higher men, this limited. analyses, however, relationship prevalence, well statistical significance, varied across groups. Future research could further explore by investigating cohorts.

Язык: Английский

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Evaluation of Complete Blood Parameters and Inflammation Markers in Spontaneous Preterm Labor

American Journal of Reproductive Immunology, Год журнала: 2025, Номер 93(2)

Опубликована: Фев. 1, 2025

ABSTRACT Aim This study aims to evaluate the relationship between systemic inflammatory markers, derived from complete blood count (CBC) parameters, and spontaneous preterm labor. By comparing these markers term pregnancies, seeks determine their potential predictive value for adverse neonatal outcomes, including birth weight, APGAR (appearance, pulse, grimace, activity, respiration) scores, intensive care unit (NICU) admission. Methods evaluated in 478 women with labor a gestational age‐matched control group. Blood samples were collected prior onset of assess CBC parameters (white cells [WBC], red [RBC], neutrophils, lymphocytes, platelet counts), as well various ratios, such immune‐inflammation index (SII), inflammation response (SIRI), aggregate (AISI). Neonatal NICU admission, recorded. Results The group showed significantly higher WBC, RBC, neutrophil, lymphocyte, counts compared MLR, MPR, MPVLR notably lower However, hematological demonstrated limited area under curve (AUC) values hovering around 0.5. Conclusions counts, along differ groups can be simple test. outcomes remains limited.

Язык: Английский

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Distinct vaginal microbiome and metabolome profiles in women with preterm delivery following cervical cerclage

Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 15

Опубликована: Фев. 11, 2025

Preterm birth (PTB) is a major cause of infant morbidity and mortality. The aim this study was to investigate the effect vaginal microbiota metabolites on outcome pregnant women. In study, total 127 women provided written informed consent prior enrollment in accordance with approved institutional guidelines, but only 45 pregnancies met experimental requirements, then blood cervical fluid (CVF) samples were collected before delivery (at second week after cerclage). Pregnant PTB exhibited high white cell neutrophil contents, neutrophil-to-lymphocyte ratio (NLR), systemic inflammation response index (SIRI) blood. Vaginal microbiome revealed that proportion beneficial bacteria (including Lactobacillus , [ Ruminococcus ] gnavus group Megamonas ) significantly decreased group, harmful Desulfovibrionaceae Helicobacter Gardnerella increased, which strongly related biochemical parameters (white cells, neutrophils, NLR, SIRI). addition, metabolomics-based liquid chromatography–Orbitrap–tandem mass spectrometry (LC-Orbitrap-MS/MS) found alteration involved starch sucrose metabolism; arginine praline galactose purine tryptophan metabolism N-glycan biosynthesis; cysteine methionine taurine hypotaurine amino acid propanoate valine, leucine, isoleucine glycine, serine, threonine steroid hormone biosynthesis. These results elaborated distinct metabolome profiles preterm following cerclage provide valuable information for establishing prediction models PTB.

Язык: Английский

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Association Between Systemic Immunity‐Inflammation Index (SII) and Fatigue, Cancer, and Cancer‐Related Fatigue: Insights From NHANES (2005–2018)

Cancer Medicine, Год журнала: 2025, Номер 14(6)

Опубликована: Март 1, 2025

ABSTRACT Objective To investigate the association between systemic immunity‐inflammation index (SII) and fatigue, cancer, cancer‐related fatigue (CRF) populations. Methods The National Health Nutrition Examination Survey (NHANES) from 2005 to 2018 provided data for this retrospective cross‐sectional study. By dividing platelet count by neutrophil lymphocyte count, SII was calculated. Participants were categorized into four groups: normal, (CRF), with normal group serving as reference. Binary logistic regression applied assess correlations. dose–response relationship outcomes in groups evaluated using restricted cubic splines. Use threshold effect analysis determine optimal value each of three groups. Stratified subgroup analyses performed based on sociodemographic factors confounders, specific attention severity levels (mild, moderate, severe) CRF Results Data included a total 32,491 participants, including 14,846 group, 14,581 1520 cancer 1544 group. results binary showed that positively correlated (1.43[1.33, 1.55]), (1.67 [1.43, 1.95]) (1.93 [1.66, 2.25]). Restricted spline revealed linear outcomes. values (k) these identified 464.78 × 10 3 cells/μL, 448.97 454.65 respectively. indicates most exhibit significant differences. indicated increased higher levels, exhibiting highest rate severe (171% increase). Conclusion is way. Higher are associated greater particularly population.

Язык: Английский

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Immune-Inflammatory Response in Lifespan. What Role Does It Play in Extreme Longevity? A Sicilian Semi- and Supercentenarians Study

Опубликована: Июнь 6, 2024

Studying models of healthy aging and exceptional longevity is crucial to understand a possible signature as most them show resistance age-related diseases. In particular, semi- supercentenarians are highly selected group, having survived significant adversities, including the Spanish Flu COVID-19 pandemics, indicating distinctive immune system characteristics. This paper analyse inflammatory scores (INFLA-score, Systemic Inflammation Response Index (SIRI)) Aging-Related Immune Phenotype (ARIP) indicators calculated from dataset DESIGN project, 249 participants aged 19-111 years, trying immune-inflammatory (IMFLAM) role achieve longevity. Statistical analyses, linear regression one-way ANOVA, were performed explore correlations between these parameters age. Both INFLA-score SIRI showed increase with However, no statistical difference observed when analysing values for those other age groups, whose similar that adults less than younger centenariansRegarding ARIP values, it noteworthy comparing CD8 Naive/Effector differences supercentenarian group groups. These results support idea control IMFLAM response can promote extreme

Язык: Английский

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Non-thyroidal disease syndrome in patients with systemic lupus erythematosus: relation to disease inflammatory activity

Clinical Rheumatology, Год журнала: 2024, Номер 43(5), С. 1551 - 1558

Опубликована: Апрель 5, 2024

Язык: Английский

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