Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Июль 14, 2023
The
present
study
attempts
to
treat
S.
aureus-induced
soft
skin
infections
using
a
combinatorial
therapy
with
an
antibiotic,
Ciprofloxacin
(CIP),
and
efflux
pump
inhibitor
5-Nitro-2-(3-phenylpropoxy)
pyridine
(5-NPPP)
through
smart
hydrogel
delivery
system.
aims
reduce
the
increasing
rates
of
antimicrobial
resistance;
therefore,
molecule
is
synthesized
delivered
along
antibiotic
re-sensitize
pathogen
towards
antibiotics
infections.
CIP-loaded
polyvinyl
alcohol
(PVA)
hydrogels
at
varying
concentrations
were
fabricated
optimized
by
chemical
cross-linking
process,
which
exhibited
sustained
drug
release
for
5
days.
compound
5-NPPP
loaded
provided
linear
2
days,
necessitating
need
development
polymeric
nanoparticles
alter
pattern.
Eudragit
RSPO
prepared
modified
nanoprecipitation-solvent
evaporation
method,
showed
optimum
average
particle
size
230-280
nm
>
90%
entrapment
efficiency.
PVA
provide
predetermined
synergistic
effect.
selected
7%
dual
drugs
evaluated
Balb/c
mice
models
induced
aureus
results
in
vivo
studies
evidence
that
non-toxic
reduced
bacterial
load
causing
re-sensitization
antibiotics,
could
initiate
re-epithelization.
research
concluded
CIP
be
ideal
promising
system
treating
Current Pharmaceutical Design,
Год журнала:
2024,
Номер
30(7), С. 519 - 535
Опубликована: Фев. 1, 2024
Abstract:
Coleus
amboinicus
Benth.,
also
known
as
Plectranthus
(Lour.)
Spreng.,
is
a
perennial
plant
from
the
Lamiaceae
family
commonly
found
in
tropical
and
warm
regions
of
Africa,
Asia,
Australia.
Folk
medicine
employs
this
remedy
to
address
various
ailments,
including
but
not
limited
asthma,
headaches,
skin
disorders,
coughs,
constipation,
colds,
fevers.
Several
phytoconstituents
phytochemical
classes,
such
phenolics,
terpenoids,
phenolic
acids,
flavonoids,
flavones,
tannins,
have
been
identified
up
present
time.
Numerous
pharmacological
properties
crude
extracts
documented
through
both
vitro
vivo
studies,
antitumor,
antibacterial,
antifungal,
antiprotozoal,
anti-inflammatory,
antioxidant,
antidiabetic,
wound
healing,
analgesic,
antirheumatic,
other
therapeutic
effects.
Due
its
extensive
history
traditional
usage,
diverse
array
bioactive
phytochemicals,
numerous
established
activities,
widely
regarded
having
significant
potential
for
clinical
applications
warrants
further
exploration,
development,
exploitation
research.
With
context,
study
gathers
information
on
occurrence,
biological
description,
cultivation,
nutritional
values
amboinicus.
Furthermore,
it
thoroughly
discusses
phytoconstituents,
along
with
their
amboinicus,
followed
by
detailed
descriptions
activities
based
recent
literature.
Biofabrication,
Год журнала:
2024,
Номер
16(3), С. 035025 - 035025
Опубликована: Май 22, 2024
Abstract
Silk
fibroin
(SF)
is
a
natural
protein
extracted
from
Bombyx
mori
silkworm
thread.
From
its
common
use
in
the
textile
industry,
it
emerged
as
biomaterial
with
promising
biochemical
and
mechanical
properties
for
applications
field
of
tissue
engineering
regenerative
medicine.
In
this
study,
we
evaluate
first
time
effects
SF
on
cardiac
bioink
formulations
containing
spheroids
(CSs).
First,
if
addition
plays
role
structural
elastic
hydrogels
alginate
(Alg)
gelatin
(Gel).
Then,
test
printability
durability
bioprinted
SF-containing
hydrogels.
Finally,
whether
controls
cell
viability
function
CSs
Alg–Gel
Our
findings
show
that
1%
(w/v)
to
makes
them
more
without
affecting
viability.
However,
fractional
shortening
(FS%)
SF–Alg–Gel
increases
their
contraction
frequency,
suggesting
an
improvement
contractile
3D
cultures.
Altogether,
our
support
pathway
bioengineer
bioinks
applications,
ability
control
cellular
features
bioinks.
