Emerging non-invasive MRI techniques for glymphatic system assessment in neurodegenerative disease

Journal of Neuroradiology, Год журнала: 2025, Номер 52(3), С. 101322 - 101322

Опубликована: Янв. 31, 2025

Язык: Английский

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Widespread and Prolonged Pain May Reduce Brain Clearance Capacity Only via Sleep Impairment: Evidence from Participants with Knee Pain

Journal of Pain, Год журнала: 2025, Номер unknown, С. 105356 - 105356

Опубликована: Март 1, 2025

Язык: Английский

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The Cerebrovascular Side of Plasticity: Microvascular Architecture across Health and Neurodegenerative and Vascular Diseases

Brain Sciences, Год журнала: 2024, Номер 14(10), С. 983 - 983

Опубликована: Сен. 28, 2024

The delivery of nutrients to the brain is provided by a 600 km network capillaries and microvessels. Indeed, highly energy demanding and, among total amount 100 billion neurons, each neuron located just 10–20 μm from capillary. This vascular also forms part blood–brain barrier (BBB), which maintains brain’s stable environment regulating chemical balance, immune cell transport, blocking toxins. Typically, microvascular endothelial cells (BMECs) have low turnover, indicating cerebrovascular structure. However, this structure can adapt significantly due development, aging, injury, or disease. Temporary neural activity changes are managed expansion contraction arterioles capillaries. Hypoxia leads significant remodeling architecture pathological been documented in aging neurodegenerative conditions. These often involve BMEC proliferation capillary segments, linked with local neuronal cognitive function. Cerebrovascular plasticity, especially arterioles, capillaries, venules, varies over different time scales health, diseases. Rapid cerebral blood flow (CBF) occur within seconds increased activity. Prolonged structure, influenced consistent environmental factors, take weeks. Development bring months years, aging-associated plasticity improved exercise. Injuries cause rapid damage but be repaired weeks months, while diseases slow, varied years. In addition, if animal models may provide useful dynamic vivo information about humans more complex investigate hypothesis glymphatic system together Magnetic Resonance Imaging (MRI) techniques could clues future.

Язык: Английский

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Glymphatic system in neurological disorders and implications for brain health

Frontiers in Neurology, Год журнала: 2025, Номер 16

Опубликована: Фев. 5, 2025

Keywords: glymphatic system, perivascular space, slow wave sleep, brain health, dementia, CSVD, stroke

Язык: Английский

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Glymphatic system: a self-purification circulation in brain

Frontiers in Cellular Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Фев. 12, 2025

The glymphatic system theory introduces a new perspective on fluid flow and homeostasis in the brain. Here, cerebrospinal interstitial (CSF-ISF) moves from perivascular spaces (PVS) of arteries to those veins for drainage. Aquaporin-4 (AQP4) plays crucial role driving within PVS. impairment AQP4 is closely linked dysfunction system. function less active during waking but enhanced sleep. efficiency decreases with aging. Damage will give rise development progression many brain diseases, such as Alzheimer’s disease (AD), Parkinson’s (PD), chronic traumatic encephalopathy (CTE), vascular dementia (VaD). we reviewed previous research associated system, including its concepts, principles, influencing factors. We hypothesize that could be target prevention treatment certain diseases through regulation

Язык: Английский

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Inadequate sleep increases stroke risk: evidence from a comprehensive meta-analysis of incidence and mortality

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Abstract The link between abnormal sleep duration and stroke outcomes remains contentious. This meta-analysis quantifies how both short long durations impact incidence mortality. A comprehensive search was conducted in PubMed, Web of Science, Cochrane Library, Embase, Google Scholar up to November 1, 2024, identify cohort studies evaluating outcomes. Meta-analysis performed using MetaAnalysisOnline.com a random-effects model estimate pooled hazard ratios (HRs). Results were visualized through Forest Funnel plots. Analysis 43 (35 on incidence, 8 mortality) revealed significant associations Short (≤ 5–6 h) associated with increased (HR 1.29, 95% CI 1.19–1.40, p < 0.01) modestly elevated mortality 1.12, 1.01–1.25, = 0.03). Long (> 8–9 demonstrated stronger 1.46, 1.33–1.60, 1.45, 1.31–1.60, 0.01). Significant heterogeneity observed ( I 2 74–75%), while analyses showed moderate low 35–40%). highlights U-shaped association risk, linked higher These findings underscore the importance balanced as modifiable risk factor prevention strategies provide foundation for Semmelweis Study, prospective workplace investigating role lifestyle factors unhealthy cerebrovascular brain aging.

Язык: Английский

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Proteinopathies and the Neurodegenerative Aftermath of Stroke: Potential Biomarkers and Treatment Targets

Stroke, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Stroke remains a predominant cause of death and long-term disability among adults worldwide. Emerging evidence suggests that proteinopathies, characterized by the aggregation accumulation misfolded proteins, may play significant role in aftermath stroke progression neurodegenerative disorders. In this review, we explore preclinical clinical research on key proteinopathies associated with stroke, including tau, Aβ (amyloid-β), TDP-43 (TAR DNA-binding protein 43), α-synuclein, UCH-L1 (ubiquitin C-terminal hydrolase-L1). We focus their potential as biomarkers for recovery management novel treatment targets enhance neuronal repair mitigate secondary neurodegeneration. The involvement these various aspects neuroinflammation, oxidative stress, damage, vascular dysfunction, underscores potential. However, further investigations are essential to validate utility biomarkers, elucidate mechanisms connecting poststroke neurodegeneration, develop targeted interventions. Identifying specific signatures outcomes could facilitate advancement precision medicine tailored individual patient needs, significantly enhancing quality life survivors.

Язык: Английский

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Clinical reflections of the glymphatic system and neurodegenerative diseases

Journal of Medical Topics and Updates, Год журнала: 2025, Номер 4(1), С. 16 - 22

Опубликована: Апрель 30, 2025

Objective: The brain is one of the main elements central nervous system and protected within bone structure formed by skull bones. endocrine play a fundamental role in maintaining homeostasis. brain; How are wastes that occur as result these biochemical events eliminated when it has such basic important tasks? Until 2012, was thought there no lymphatic brain. Our aim with this literature review to make easier find answers questions. Materials Methods: For research, existing systematically reviewed terms glymphatic system. Results: brain’s waste clearance mechanism. Many anatomical structures involved Astrocytes aquaporin-4 channels were most notable these. Conclusions: clearing mechanism many function mechanisms. Although been subject current research human animal experiments recent years, still an area preserves its mystery. remains mysterious. Disruption closely associated neurodegenerative diseases. We believe system, which plays vital health, should be more scientific clarify functioning

Язык: Английский

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Integrative MR Imaging Interpretation in Cognitive Impairment with Alzheimer's Disease, Small Vessel Disease, and Glymphatic Function-Related MR Parameters

Academic Radiology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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Cerebral small vessel disease and glymphatic system dysfunction in Multiple Sclerosis: a narrative review

Multiple Sclerosis and Related Disorders, Год журнала: 2024, Номер 91, С. 105878 - 105878

Опубликована: Сен. 6, 2024

Язык: Английский

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