Molecular Neurobiology, Год журнала: 2022, Номер 59(10), С. 6373 - 6396
Опубликована: Авг. 6, 2022
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(12), С. 6827 - 6827
Опубликована: Июнь 19, 2022
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are essential for neuronal survival and growth. The signaling cascades initiated by BDNF its receptor the key regulators of synaptic plasticity, which plays important role in learning memory formation. Changes levels pathways have been identified several neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s Huntington’s linked with symptoms course these diseases. This review summarizes current understanding well underlying molecular mechanism. therapeutic potential treatment is also discussed, hope discovering new avenues
Язык: Английский
Процитировано
125
Neurobiology of Disease, Год журнала: 2023, Номер 187, С. 106314 - 106314
Опубликована: Окт. 1, 2023
Poly (ADP-ribose) polymerase-1 (PARP-1) is the most extensively studied member of PARP superfamily, with its primary function being facilitation DNA damage repair processes. Parthanatos a type regulated cell death cascade initiated by PARP-1 hyperactivation, which involves multiple subroutines, including accumulation ADP-ribose polymers (PAR), binding PAR and apoptosis-inducing factor (AIF), release AIF from mitochondria, translocation AIF/macrophage migration inhibitory (MIF) complex, massive MIF-mediated fragmentation. Over past few decades, role in central nervous system health disease has received increasing attention. In this review, we discuss biological functions neural proliferation differentiation, memory formation, brain ageing, epigenetic regulation. We then elaborate on involvement PARP-1-dependant parthanatos various neuropathological processes, such as oxidative stress, neuroinflammation, mitochondrial dysfunction, excitotoxicity, autophagy damage, endoplasmic reticulum (ER) stress. Additional highlight contains PARP-1's implications initiation, progression, therapeutic opportunities for different neurological illnesses, neurodegenerative diseases, stroke, autism spectrum disorder (ASD), sclerosis (MS), epilepsy, neuropathic pain (NP). Finally, emerging insights into repurposing inhibitors management diseases are provided. This review aims to summarize exciting advancements critical disorders, may open new avenues options targeting or parthanatos.
Язык: Английский
Процитировано
28
Genes, Год журнала: 2023, Номер 14(2), С. 325 - 325
Опубликована: Янв. 27, 2023
Amyotrophic lateral sclerosis (ALS) is described as a fatal and rapidly progressive neurodegenerative disorder caused by the degeneration of upper motor neurons in primary cortex lower brainstem spinal cord. Due to ALS’s slowly characteristic, which often accompanied other neurological comorbidities, its diagnosis remains challenging. Perturbations vesicle-mediated transport autophagy well cell-autonomous disease initiation glutamatergic have been revealed ALS. The use extracellular vesicles (EVs) may be key accessing pathologically relevant tissues for ALS, EVs can cross blood–brain barrier isolated from blood. number content provide indications pathogenesis, stage, prognosis. In this review, we collected recent study aiming at identification biomarker ALS with respect size, quantity, biological fluids patients compared controls.
Язык: Английский
Процитировано
22
Antioxidants, Год журнала: 2024, Номер 13(7), С. 762 - 762
Опубликована: Июнь 24, 2024
Neurodegenerative diseases are a significant challenge to global healthcare, and oxidative stress plays crucial role in their development. This paper presents comprehensive analysis of the neuroprotective potential olive oil, with primary focus on its antioxidant properties. The chemical composition including key antioxidants, such as oleuropein, hydroxytyrosol, oleocanthal, is systematically examined. mechanisms by which these compounds provide neuroprotection, counteracting damage modulating pathways, explored. efficacy oil evaluated synthesizing findings from various sources, vitro studies, animal models, clinical trials. integration into dietary patterns, particularly Mediterranean diet, broader implications neurodegenerative disease prevention also discussed. challenges translating preclinical applications acknowledged future research directions proposed better understand mitigating risk conditions. review highlights not only component, but promising candidate preventive neurology, advocating for further investigation context diseases.
Язык: Английский
Процитировано
9
Journal of Food Biochemistry, Год журнала: 2022, Номер 46(12)
Опубликована: Окт. 7, 2022
Moringa oleifera is a traditional Indian herb belonging to the Moringaceae family, it commonly known as horse-radish tree, drumstick, or sahajna. In developing countries, used feed for both humans and animals due its well-known antioxidant, anti-inflammatory, anti-apoptotic properties owing several phytoconstituents including β-carotene, quercetin, kaempferol, ascorbic acid, flavonoids, phenolic rhamnose, glycosylates, glucomoringin, isothiocyanates. These constituents help maintain brain antioxidant enzyme levels, mitochondrial functions, neurogenesis, showing neuroprotective effects in neurodegenerative disorders Parkinson's Disease, Alzheimer's Huntington's Amyotrophic lateral sclerosis. This review discusses various phytoconstituent of moringa their therapeutic potential neurological disorders. Additionally, we also concise safety toxicity profile, different molecular pathways involved effect M. nanoparticles better value. Practical applications Several clinical preclinical studies on have been conducted, outcomes indicate could be treatment As result, conclude that nanoformulations employed treat problems. future, evaluated against specific signaling pathways, which aid researchers discovering mechanism action. Furthermore, use nutraceutical myriad pharmacological will go long way boosting economy countries grow large scale.
Язык: Английский
Процитировано
28
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(20), С. 15430 - 15430
Опубликована: Окт. 21, 2023
In the last two decades, there has been increasing evidence supporting non-neuronal cells as active contributors to neurodegenerative disorders. Among glial cells, astrocytes play a pivotal role in driving amyotrophic lateral sclerosis (ALS) progression, leading scientific community focus on "astrocytic signature" ALS. Here, we summarized main pathological mechanisms characterizing astrocyte contribution MN damage and ALS such neuroinflammation, mitochondrial dysfunction, oxidative stress, energy metabolism impairment, miRNAs extracellular vesicles contribution, autophagy protein misfolding, altered neurotrophic factor release. Since glutamate excitotoxicity is one of most relevant features, focused specific this aspect, highlighting known or potential molecular by which participate level and, conversely, undergo toxic effect excessive glutamate. scenario, can behave "producers" "targets" high levels, going through changes that affect themselves turn, neuronal surrounding thus actively impacting course. Moreover, review aims point out knowledge gaps deserve further investigation.
Язык: Английский
Процитировано
19
Frontiers in Neurology, Год журнала: 2023, Номер 14
Опубликована: Апрель 20, 2023
There are trillions of different microorganisms in the human digestive system. These gut microbes involved digestion food and its conversion into nutrients required by body. In addition, microbiota communicates with other parts body to maintain overall health. The connection between brain is known as gut–brain axis (GBA), involves connections via central nervous system (CNS), enteric (ENS), endocrine immune pathways. regulates bottom-up through GBA, which has prompted researchers pay considerable attention potential pathways might play a role prevention treatment amyotrophic lateral sclerosis (ALS). Studies animal models ALS have shown that dysregulation ecology leads brain–gut signaling. This, turn, induces changes intestinal barrier, endotoxemia, systemic inflammation, contribute development ALS. Through use antibiotics, probiotic supplementation, phage therapy, methods inducing can inhibit inflammation delay neuronal degeneration, clinical symptoms be alleviated, progression disease delayed. Therefore, may key target for effective management
Язык: Английский
Процитировано
18
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Янв. 4, 2024
Summary Amyotrophic lateral sclerosis affects upper and lower motor neurons, causing progressive neuropathology leading to structural functional alterations of affected neural networks long prior development symptoms. Certain genetic mutations, such as expansions in C9orf72 , predispose neuron populations pathological dysfunction. However, it is not known how underlying predisposition dynamics within vulnerable networks. Here, we studied micro-and mesoscale ALS patient derived over time. We show, for the first time, that neurons with endogenous develop classical cytopathology form cytoplasmic TDP-43 inclusions self-organise into computationally efficient networks, albeit hallmarks higher metabolic cost compared healthy controls. These included microscale impairments compensation including increased centralisation function. Moreover, show these are highly susceptible transient perturbation by exhibiting induced hyperactivity.
Язык: Английский
Процитировано
6
Toxicology Reports, Год журнала: 2022, Номер 9, С. 977 - 998
Опубликована: Янв. 1, 2022
Methylmercury (MeHg+) is a known neurotoxin that causes progressive motor neuron degeneration in the central nervous system. Axonal degeneration, oligodendrocyte and myelin basic protein (MBP) deficits are among neuropathological abnormalities caused by MeHg+ amyotrophic lateral sclerosis (ALS). This results demyelination death both humans animals. Previous experimental studies have confirmed overexpression of extracellular signalling regulated kinase (ERK1/2) contributes to glutamate excitotoxicity, inflammatory response microglial cells, (OL) dysfunction promotes loss. Alpha-mangostin (AMG), an active ingredient obtained from tree "Garcinia mangostana Linn," has been used animals treat variety brain disorders, including Parkinson's Huntington's disease memory impairment, Alzheimer's disease, schizophrenia, schizophrenia. AMG traditionally as antioxidant, anti-inflammatory, neuroprotective agent.Accordingly, we investigated therapeutic potential (100 200 mg/kg) rats with methylmercury (MeHg+)-induced neurotoxicity. The effect on behavioural, cellular, molecular, other gross pathological changes, such histopathological alterations -treated rat brains, presented. neurological behaviour was evaluated using Morris water maze (MWM), open field test (OFT), grip strength (GST), force swim (FST). In addition, investigate AMG's restoring MBP levels cerebral spinal fluid whole homogenate. apoptotic, pro-inflammatory, oxidative stress markers were measured blood plasma samples According findings this study, decreases ERK-1/2 modulates neurochemical minimising -induced
Язык: Английский
Процитировано
25
The Neuroscientist, Год журнала: 2022, Номер 30(1), С. 71 - 86
Опубликована: Сен. 17, 2022
Vascular endothelial growth factor (VEGF) is well known for its angiogenic activity, but recent evidence has revealed a neuroprotective action of this on injured or diseased neurons. In the present review, we summarize most relevant findings that have contributed to establish link between VEGF deficiency and neuronal degeneration. At issue, 1) mutant mice with reduced levels show adult-onset muscle weakness motoneuron degeneration resembling amyotrophic lateral sclerosis (ALS), 2) administration different animal models improves motor performance ameliorates motoneuronal degeneration, 3) there an association low plasmatic human ALS. Altogether, results presented in review highlight as essential neurotrophic endowed promising therapeutic potential treatment disorders.
Язык: Английский
Процитировано
20