Ang-1 and VEGF: central regulators of angiogenesis

Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown

Опубликована: Апрель 23, 2024

Язык: Английский

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Inhibition of Vascular Endothelial Growth Factor Reduces Photoreceptor Death in Retinal Neovascular Disease via Neurotrophic Modulation in Müller Glia

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Язык: Английский

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Biocompatibility and Therapeutic Efficacy of Crosslinked Hydrogel Filled 3D-Printed Nerve Conduit for Sacral Nerve Injury Repair

Biomaterials, Год журнала: 2025, Номер 320, С. 123230 - 123230

Опубликована: Март 4, 2025

Язык: Английский

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Beyond vessels: unraveling the impact of VEGFs on neuronal functions and structure

Journal of Biomedical Science, Год журнала: 2025, Номер 32(1)

Опубликована: Март 6, 2025

Neurons rely on the bloodstream for essential nutrients and oxygen, which is facilitated by an intricate coupling of neuronal vascular systems. Central to this neurovascular interaction endothelial growth factor (VEGF) family, a group secreted factors traditionally known their roles in promoting cell proliferation, migration, survival cardiovascular lymphatic However, emerging evidence shows that VEGFs also play indispensable nervous system, extending beyond canonical angiogenic lymphangiogenic functions. Over past two decades, have been found exert direct effects neurons, influencing key aspects function independently actions cells. In particular, it has become increasingly evident crucial functions development, regulation, maintenance morphology. Understanding development high scientific clinical interest because significance precise morphology neural connectivity network function, as well association morphological abnormalities with neurological neurodegenerative disorders. This review begins overview VEGF family members, structural characteristics, receptors, established vasculature. then highlights focuses exciting variety VEGFs, especially role

Язык: Английский

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Research progress on exosome-mediated vascular endothelial growth factor–nerve growth factor cotransplantation in the treatment of Parkinson’s disease

Deleted Journal, Год журнала: 2025, Номер 2(1), С. 11 - 15

Опубликована: Янв. 13, 2025

The significant decrease in dopamine (DA) neurotransmitter levels the brain due to degeneration and loss of dopaminergic neurons is one main reasons for causes motor symptoms Parkinson disease. Vascular endothelial growth factor has been proven have a protective effect on DA neurons. Its synergistic interaction with nerve can accelerate repair damaged nerves improve central nervous system. However, presence blood-brain barrier hinders most drugs from entering brain. Exosomes are class nanoscale extracellular vesicles advantages such as higher safety, low immunogenicity, unique targeted homing ability, efficient penetration barrier, which open new perspective drug delivery system provide possibilities treatment neurodegenerative diseases. This article reviews research progress exosomes above 2 factors repair, ideas

Язык: Английский

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Influence of Fructose-Fat Diet on Age-Related Morphological Changes in Rats Visual Cortex

Journal of Anatomy and Histopathology, Год журнала: 2025, Номер 14(1), С. 36 - 44

Опубликована: Апрель 7, 2025

The aim was to study the morphological changes in visual cortex of brain young and old rats treated with a fructose-fat diet (FFD). Material methods . carried out on male Wistar rats, divided into following groups: 1st (n=14) – intact 6-month-old received standard diet; 2nd (FFD) for 90 days (from 3 months age); 3rd (n = 14) 18-month-old 4th FFD 15 age). Histological sections were Nissl stained. Immunohistochemical reaction performed detect expression vascular endothelial growth factor (VEGF). In layers II, IV V primary cortex, percentage normochromic altered neurons number gliocytes 1 mm2 section calculated. Differences between groups determined using Kruskal–Wallis multiple comparison test. Results Morphological most pronounced and, addition reversible neuronal disorders, characterized by total chromatolysis vacuolization cytoplasm. FFD, increase hyperchromic shrinkage observed layer IV. animals, pathological neurocytes found all studied signs neuronophagia gliosis noted. 6- congestion perivascular edema VEGF detected. Conclusion enhances age-related manifested degenerative glial hyperreactivity.

Язык: Английский

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A review of the effects of early postnatal hyperoxia exposure on the immature brain

Experimental Neurology, Год журнала: 2023, Номер 370, С. 114550 - 114550

Опубликована: Сен. 27, 2023

Preterm birth is a public health priority worldwide, with approximately 15 million premature babies born each year. Oxygen supplementation one of the most common interventions for preterm infants. However, prolonged oxygen inhalation at supraphysiological concentrations can lead to development bronchopulmonary dysplasia (BPD). In addition lifelong pulmonary sequelae, clinical evidence suggests that BPD associated adverse neurodevelopmental outcomes, such as motor impairment, cognitive and behavioral deficits, severely affecting quality life mechanisms underlying combination impairment remain unclear. Therefore, in recent years, attention has also been focused on effects hyperoxia brain this review, we outline pathophysiological injury caused by developmental exposure current animal models briefly describe pharmacological therapies may be applicable injury. Overall, more studies are needed assess immature brain, particularly combined analyses lungs same experimental setting, elucidate potential causes BPD.

Язык: Английский

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Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases

Biomedicines, Год журнала: 2024, Номер 12(8), С. 1906 - 1906

Опубликована: Авг. 20, 2024

Hereditary neurodegenerative diseases (hNDDs) such as Alzheimer's, Parkinson's, Huntington's disease, and others are primarily characterized by their progressive nature, severely compromising both the cognitive motor abilities of patients. The underlying genetic component in hNDDs contributes to disease risk, creating a complex landscape. Considering fact that growth factors play crucial roles regulating cellular processes, proliferation, differentiation, survival, they could have therapeutic potential for hNDDs, provided appropriate dosing safe delivery approaches ensured. This article presents detailed overview factors, explores treating emphasizing neuronal growth, synaptic plasticity. However, challenges proper dosing, methods, patient variability can hinder clinical application.

Язык: Английский

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Gene Therapy for Parkinson’s Disease Using Midbrain Developmental Genes to Regulate Dopaminergic Neuronal Maintenance

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12369 - 12369

Опубликована: Ноя. 18, 2024

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder. It characterized by progressive loss of dopaminergic (DAnergic) neurons in substantia nigra and decreased dopamine (DA) levels, which lead to both motor non-motor symptoms. Conventional PD treatments aim alleviate symptoms, but do not delay progression. gene therapy offers a promising approach improving current treatments, with potential significant symptoms cause fewer adverse effects than conventional therapies. DA replacement approaches enzyme expression slow However, therapies, such as adeno-associated virus (AAV)-glutamic acid decarboxylase (GAD) L-amino (AADC) increase transmitter have been demonstrated be safe efficient early-phase clinical trials. Disease-modifying strategies, progression, appear potent. These include therapies targeting downstream pathways, neurotrophic factors, midbrain DAnergic neuronal all shown preclinical focus on maintaining integrity neurons, just level itself. In particular, critical developmental maintenance Nurr1 Foxa2, can interact synergistically neighboring glia, paracrine mode action, protect against various toxic factors. Similar outcomes could achieved glial cells other candidate in-depth research needed. Neurotrophic neurturin, glial-cell-line-derived factor (GDNF), brain-derived (BDNF), vascular endothelial growth (VEGF), are also being investigated for their support neuron survival. Additionally, key autophagy-lysosome pathway, mitochondrial function, endoplasmic reticulum (ER) stress, offer avenues. Gene editing delivery techniques continue evolve, presenting new opportunities develop effective PD.

Язык: Английский

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VEGF, but Not BDNF, Prevents the Downregulation of KCC2 Induced by Axotomy in Extraocular Motoneurons

Опубликована: Авг. 15, 2024

The potassium-chloride cotransporter KCC2 is the main extruder of Cl- in neurons. It plays a fundamental role activity inhibitory neurotransmitters (GABA and glycine) since low levels promote intracellular accumulation leading to depolarizing GABA glycine. Downregulation this occurs neurological disorders characterized by hyperexcitability, such as epilepsy, neuropathic pain spasticity. also downregulated after axotomy. If muscle reinnervation allowed, recover motoneurons. Therefore, we argued that target-derived neurotrophic factors might be involved regulation expression. For purpose, performed axotomy extraocular motoneurons monocular enucleation adult rats, pellet containing either VEGF or BDNF was chronically implanted orbit. Double confocal immunofluorescence ChAT carried out brainstem sections. Axotomy led decrease neuropil soma motoneurons, peaking at 15 days post-lesion, with exception abducens motoneuron somata. administration prevented axotomy-induced downregulation. By contrast, maintained reduced following suggesting downregulation finding prevents opens new possibilities for treatment coursing neuronal hyperactivity due

Язык: Английский

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