Journal of Materials Chemistry B,
Год журнала:
2023,
Номер
11(35), С. 8433 - 8448
Опубликована: Янв. 1, 2023
Mitochondria-targeted
copper-depletion
is
emerging
as
an
attractive
strategy
to
combat
cancer.
However,
existing
copper
molecular
chelators
are
non-specific,
toxic
and
ineffective.
Here,
it
reported
that
multifunctional
nanoparticles
(MSN-TPP/BNA-DPA)
can
not
only
target
mitochondria
deprive
ions
trigger
therapy,
but
also
serve
nanocarriers
deliver
anticancer
drugs
for
chemotherapy,
which
engineered
by
conjugating
a
fluorophore
4-bromo-1,8-naphthalicanhydride
(BNA),
copper-depriving
moiety
dimethylpyridinamine
(DPA)
mitochondrial
targeting
ligand
triphenylphosphonium
(TPP)
on
the
surface
of
mesoporous
silica
(MSN).
BNA
internal
charge
transfer
compound
BNA-DPA
endow
MSN-TPP/BNA-DPA
with
green
fluorescence
emission
upon
UV
excitation,
be
used
monitor
cellular
uptake
nanoparticles.
When
bind
DPA,
quenched,
providing
visualization
feedback
copper-depletion.
Therapeutically,
mitochondria-targeted
effectively
causes
damage,
elevated
oxidative
stress
reduced
ATP
production
induce
intensive
cancer
cell
death.
Moreover,
structure
enables
doxorubicin
chemotherapy
enhances
therapy
through
H2O2
production.
Together,
synergistic
therapeutic
effect
enhanced
doxorubicin-mediated
achieves
remarkable
cell-killing
significant
tumor
growth
inhibition
in
4T1
tumor-bearing
mice.
This
work
provides
efficacious
based
therapy.
Molecular Aspects of Medicine,
Год журнала:
2023,
Номер
93, С. 101205 - 101205
Опубликована: Июль 27, 2023
Anthracyclines
have
been
important
and
effective
treatments
against
a
number
of
cancers
since
their
discovery.
However,
use
in
therapy
has
complicated
by
severe
side
effects
toxicity
that
occur
during
or
after
treatment,
including
cardiotoxicity.
The
mode
action
anthracyclines
is
complex,
with
several
mechanisms
proposed.
It
possible
high
due
to
the
large
set
processes
involved
anthracycline
action.
development
resistance
major
barrier
successful
treatment
when
using
anthracyclines.
This
based
on
series
studied
addressed
recent
years.
work
provides
an
overview
used
cancer
therapy.
discusses
activity,
toxicity,
chemoresistance,
as
well
approaches
improve
decrease
overcome
resistance.
Bioengineering & Translational Medicine,
Год журнала:
2022,
Номер
8(1)
Опубликована: Июнь 8, 2022
Urological
cancers
are
among
the
most
common
malignancies
around
world.
In
particular,
bladder
cancer
severely
threatens
human
health
due
to
its
aggressive
and
heterogeneous
nature.
Various
therapeutic
modalities
have
been
considered
for
treatment
of
although
prognosis
remains
unfavorable.
It
is
perceived
that
depends
on
an
interdisciplinary
approach
combining
biology
engineering.
The
nanotechnological
approaches
introduced
in
various
cancers,
especially
cancer.
current
review
aims
emphasize
highlight
possible
applications
nanomedicine
eradication
tumor.
Nanoparticles
can
improve
efficacy
drugs
therapy
through
elevating
their
bioavailability.
potential
genetic
tools
such
as
siRNA
miRNA
gene
expression
regulation
be
boosted
using
nanostructures
by
facilitating
internalization
accumulation
at
tumor
sites
cells.
provide
photodynamic
photothermal
ROS
overgeneration
hyperthermia,
respectively,
suppression
Furthermore,
remodeling
microenvironment
infiltration
immune
cells
purpose
immunotherapy
achieved
cargo-loaded
nanocarriers.
Nanocarriers
mainly
internalized
endocytosis,
proper
design
smart
nanoparticles
pH-,
redox-,
light-responsive
nanocarriers
importance
targeted
therapy.
Bladder
biomarkers
detected
timely
diagnosis
patients.
Based
site,
they
employed
imaging.
clinical
translation
challenges
also
covered
review.
Chemical Reviews,
Год журнала:
2024,
Номер
124(13), С. 8307 - 8472
Опубликована: Июнь 26, 2024
Due
to
the
intrinsic
non-invasive
nature,
cost-effectiveness,
high
safety,
and
real-time
capabilities,
besides
diagnostic
imaging,
ultrasound
as
a
typical
mechanical
wave
has
been
extensively
developed
physical
tool
for
versatile
biomedical
applications.
Especially,
prosperity
of
nanotechnology
nanomedicine
invigorates
landscape
ultrasound-based
medicine.
The
unprecedented
surge
in
research
enthusiasm
dedicated
efforts
have
led
mass
multifunctional
micro-/nanosystems
being
applied
biomedicine,
facilitating
precise
diagnosis,
effective
treatment,
personalized
theranostics.
deployment
applications
is
rooted
profound
understanding
relationship
among
composition,
structure,
property,
bioactivity,
application,
performance.
In
this
comprehensive
review,
we
elaborate
on
general
principles
regarding
design,
synthesis,
functionalization,
optimization
abundant
particular,
recent
advancements
imaging
are
meticulously
summarized.
Furthermore,
systematically
elucidate
state-of-the-art
studies
concerning
progress
therapeutic
targeting
various
pathological
abnormalities
including
cancer,
bacterial
infection,
brain
diseases,
cardiovascular
metabolic
diseases.
Finally,
conclude
provide
an
outlook
field
with
in-depth
discussion
challenges
faced
future
developments
further
extensive
clinical
translation
application.
Redox Biology,
Год журнала:
2024,
Номер
72, С. 103129 - 103129
Опубликована: Март 19, 2024
Doxorubicin
is
a
powerful
chemotherapeutic
agent
for
cancer,
whose
use
limited
due
to
its
potential
cardiotoxicity.
Semaglutide
(SEMA),
novel
analog
of
glucagon-like
peptide-1
(GLP-1),
has
received
widespread
attention
the
treatment
diabetes.
However,
increasing
evidence
highlighted
therapeutic
benefits
on
cardiac
function.
Therefore,
objective
this
study
was
examine
efficacy
semaglutide
in
ameliorating
doxorubicin-induced
Bioengineering & Translational Medicine,
Год журнала:
2022,
Номер
8(1)
Опубликована: Сен. 13, 2022
Green
chemistry
has
been
a
growing
multidisciplinary
field
in
recent
years
showing
great
promise
biomedical
applications,
especially
for
cancer
therapy.
Chitosan
(CS)
is
an
abundant
biopolymer
derived
from
chitin
and
present
insects
fungi.
This
polysaccharide
favorable
characteristics,
including
biocompatibility,
biodegradability,
ease
of
modification
by
enzymes
chemicals.
CS-based
nanoparticles
(CS-NPs)
have
shown
potential
the
treatment
other
diseases,
affording
targeted
delivery
overcoming
drug
resistance.
The
current
review
emphasizes
on
application
CS-NPs
chemotherapeutic
agent,
doxorubicin
(DOX),
therapy
as
they
promote
internalization
DOX
cells
prevent
activity
P-glycoprotein
(P-gp)
to
reverse
These
nanoarchitectures
can
provide
co-delivery
with
antitumor
agents
such
curcumin
cisplatin
induce
synergistic
Furthermore,
co-loading
siRNA,
shRNA,
miRNA
suppress
tumor
progression
chemosensitivity.
Various
nanostructures,
lipid-,
carbon-,
polymeric-
metal-based
nanoparticles,
are
modifiable
CS
delivery,
while
functionalization
ligands
hyaluronic
acid
promotes
selectivity
toward
prevents
demonstrate
high
encapsulation
efficiency
due
protonation
amine
groups
CS,
pH-sensitive
release
occur.
redox-
light-responsive
prepared
treatment.
Leveraging
these
characteristics
view
biocompatibility
CS-NPs,
we
expect
soon
see
significant
progress
towards
clinical
translation.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(5), С. 2077 - 2096
Опубликована: Фев. 23, 2024
Aberrant
tumor
blood
vessels
are
prone
to
propel
the
malignant
progression
of
tumors,
and
targeting
abnormal
metabolism
endothelial
cells
emerges
as
a
promising
option
achieve
vascular
normalization
antagonize
progression.
Herein,
we
demonstrated
that
salvianic
acid
A
(SAA)
played
pivotal
role
in
contributing
tumor-bearing
mice,
thereby
improving
delivery
effectiveness
chemotherapeutic
agent.
SAA
was
capable
inhibiting
glycolysis
strengthening
junctions
human
umbilical
vein
(HUVECs)
exposed
hypoxia.
Mechanistically,
inclined
directly
bind
glycolytic
enzyme
PKM2,
leading
dramatic
decrease
glycolysis.
More
importantly,
improved
integrity
via
activating
β-Catenin/Claudin-5
signaling
axis
PKM2-dependent
manner.
Our
findings
suggest
may
serve
potent
agent
for
inducing
normalization.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Ноя. 17, 2023
Triple
positive
breast
cancer
(TPBC)
is
one
of
the
most
aggressive
cancer.
Due
to
unique
cell
phenotype,
aggressiveness,
metastatic
potential
and
lack
receptors
or
targets,
chemotherapy
choice
treatment
for
TNBC.
Doxorubicin
(DOX),
representative
agents
anthracycline
chemotherapy,
has
better
efficacy
in
patients
with
TNBC
(mTNBC).
DOX
anthracycline-based
regimens
have
higher
response
rates.
Nano-drug
delivery
systems
possess
targeting
ability
co-load,
deliver
release
chemotherapeutic
drugs,
active
gene
fragments
immune
enhancing
factors
effectively
inhibit
kill
tumor
cells.
Therefore,
advances
nano-drug
therapy
attracted
a
considerable
amount
attention
from
researchers.
In
this
article,
we
reviewed
progress
(e.g.,
Nanoparticles,
Liposomes,
Micelles,
Nanogels,
Dendrimers,
Exosomes,
etc.)
applied
We
also
summarize
current
clinical
trials
combined
checkpoint
inhibitors
(ICIS)
The
merits,
demerits
future
development
nanomedicine
are
envisioned,
aim
providing
new
class
safe
efficient
thoughts
Journal of Taibah University Medical Sciences,
Год журнала:
2024,
Номер
19(4), С. 806 - 815
Опубликована: Июль 22, 2024
Dasatinib
(DS),
a
second-generation
tyrosine
kinase
inhibitor,
functions
as
multi-target
small-molecule
drug
via
targeting
various
kinases
involved
in
neoplastic
cell
growth.
DS
inhibits
cancer
replication
and
migration,
induces
tumor
apoptosis
variety
of
solid
tumors.
However,
it
is
poorly
soluble
water
under
some
pH
values.
Therefore,
the
development
DS-containing,
self-emulsifying,
delivery
system
(SeDDs)
could
help
overcome
these
problems
treating
cells.
