Smart design of a therapeutic nanoplatform for mitochondria-targeted copper-depletion therapy combined with chemotherapy DOI

Taishun Hu,

Xiyu Gong,

Xinli Liu

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(35), P. 8433 - 8448

Published: Jan. 1, 2023

Mitochondria-targeted copper-depletion is emerging as an attractive strategy to combat cancer. However, existing copper molecular chelators are non-specific, toxic and ineffective. Here, it reported that multifunctional nanoparticles (MSN-TPP/BNA-DPA) can not only target mitochondria deprive ions trigger therapy, but also serve nanocarriers deliver anticancer drugs for chemotherapy, which engineered by conjugating a fluorophore 4-bromo-1,8-naphthalicanhydride (BNA), copper-depriving moiety dimethylpyridinamine (DPA) mitochondrial targeting ligand triphenylphosphonium (TPP) on the surface of mesoporous silica (MSN). BNA internal charge transfer compound BNA-DPA endow MSN-TPP/BNA-DPA with green fluorescence emission upon UV excitation, be used monitor cellular uptake nanoparticles. When bind DPA, quenched, providing visualization feedback copper-depletion. Therapeutically, mitochondria-targeted effectively causes damage, elevated oxidative stress reduced ATP production induce intensive cancer cell death. Moreover, structure enables doxorubicin chemotherapy enhances therapy through H2O2 production. Together, synergistic therapeutic effect enhanced doxorubicin-mediated achieves remarkable cell-killing significant tumor growth inhibition in 4T1 tumor-bearing mice. This work provides efficacious based therapy.

Language: Английский

Doxorubicin and other anthracyclines in cancers: Activity, chemoresistance and its overcoming DOI Creative Commons
Roberto Mattioli, Andrea Ilari,

Beatrice Colotti

et al.

Molecular Aspects of Medicine, Journal Year: 2023, Volume and Issue: 93, P. 101205 - 101205

Published: July 27, 2023

Anthracyclines have been important and effective treatments against a number of cancers since their discovery. However, use in therapy has complicated by severe side effects toxicity that occur during or after treatment, including cardiotoxicity. The mode action anthracyclines is complex, with several mechanisms proposed. It possible high due to the large set processes involved anthracycline action. development resistance major barrier successful treatment when using anthracyclines. This based on series studied addressed recent years. work provides an overview used cancer therapy. discusses activity, toxicity, chemoresistance, as well approaches improve decrease overcome resistance.

Language: Английский

Citations

114
(Nano)platforms in bladder cancer therapy: Challenges and opportunities DOI
Milad Ashrafizadeh, Ali Zarrabi, Hassan Karimi‐Maleh

et al.

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(1)

Published: June 8, 2022

Urological cancers are among the most common malignancies around world. In particular, bladder cancer severely threatens human health due to its aggressive and heterogeneous nature. Various therapeutic modalities have been considered for treatment of although prognosis remains unfavorable. It is perceived that depends on an interdisciplinary approach combining biology engineering. The nanotechnological approaches introduced in various cancers, especially cancer. current review aims emphasize highlight possible applications nanomedicine eradication tumor. Nanoparticles can improve efficacy drugs therapy through elevating their bioavailability. potential genetic tools such as siRNA miRNA gene expression regulation be boosted using nanostructures by facilitating internalization accumulation at tumor sites cells. provide photodynamic photothermal ROS overgeneration hyperthermia, respectively, suppression Furthermore, remodeling microenvironment infiltration immune cells purpose immunotherapy achieved cargo-loaded nanocarriers. Nanocarriers mainly internalized endocytosis, proper design smart nanoparticles pH-, redox-, light-responsive nanocarriers importance targeted therapy. Bladder biomarkers detected timely diagnosis patients. Based site, they employed imaging. clinical translation challenges also covered review.

Language: Английский

Citations

93
Strategies to overcome cancer multidrug resistance (MDR) through targeting P-glycoprotein (ABCB1): An updated review DOI
Jinyun Dong, Yuan Li, Can Hu

et al.

Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 249, P. 108488 - 108488

Published: July 11, 2023

Language: Английский

Citations

66
Ultrasound-Based Micro-/Nanosystems for Biomedical Applications DOI
Hui Huang,

Yi Zheng,

Meiqi Chang

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(13), P. 8307 - 8472

Published: June 26, 2024

Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.

Language: Английский

Citations

32
Semaglutide attenuates doxorubicin-induced cardiotoxicity by ameliorating BNIP3-Mediated mitochondrial dysfunction DOI Creative Commons
Xiaoping Li, Wenbin Luo,

Yang Tang

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 72, P. 103129 - 103129

Published: March 19, 2024

Doxorubicin is a powerful chemotherapeutic agent for cancer, whose use limited due to its potential cardiotoxicity. Semaglutide (SEMA), novel analog of glucagon-like peptide-1 (GLP-1), has received widespread attention the treatment diabetes. However, increasing evidence highlighted therapeutic benefits on cardiac function. Therefore, objective this study was examine efficacy semaglutide in ameliorating doxorubicin-induced

Language: Английский

Citations

16
Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy DOI
Milad Ashrafizadeh, Kiavash Hushmandi, Sepideh Mirzaei

et al.

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(1)

Published: Sept. 13, 2022

Green chemistry has been a growing multidisciplinary field in recent years showing great promise biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and present insects fungi. This polysaccharide favorable characteristics, including biocompatibility, biodegradability, ease of modification by enzymes chemicals. CS-based nanoparticles (CS-NPs) have shown potential the treatment other diseases, affording targeted delivery overcoming drug resistance. The current review emphasizes on application CS-NPs chemotherapeutic agent, doxorubicin (DOX), therapy as they promote internalization DOX cells prevent activity P-glycoprotein (P-gp) to reverse These nanoarchitectures can provide co-delivery with antitumor agents such curcumin cisplatin induce synergistic Furthermore, co-loading siRNA, shRNA, miRNA suppress tumor progression chemosensitivity. Various nanostructures, lipid-, carbon-, polymeric- metal-based nanoparticles, are modifiable CS delivery, while functionalization ligands hyaluronic acid promotes selectivity toward prevents demonstrate high encapsulation efficiency due protonation amine groups CS, pH-sensitive release occur. redox- light-responsive prepared treatment. Leveraging these characteristics view biocompatibility CS-NPs, we expect soon see significant progress towards clinical translation.

Language: Английский

Citations

62
Nano-formulated siRNA-based therapeutic approaches for cancer therapy DOI Creative Commons
Dolly Jain, Shiv Kumar Prajapati, Ankit Jain

et al.

Nano Trends, Journal Year: 2023, Volume and Issue: 1, P. 100006 - 100006

Published: March 1, 2023

Language: Английский

Citations

23
Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery DOI Creative Commons
Cheng Qian,

Yueke Zhou,

Teng Zhang

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(5), P. 2077 - 2096

Published: Feb. 23, 2024

Aberrant tumor blood vessels are prone to propel the malignant progression of tumors, and targeting abnormal metabolism endothelial cells emerges as a promising option achieve vascular normalization antagonize progression. Herein, we demonstrated that salvianic acid A (SAA) played pivotal role in contributing tumor-bearing mice, thereby improving delivery effectiveness chemotherapeutic agent. SAA was capable inhibiting glycolysis strengthening junctions human umbilical vein (HUVECs) exposed hypoxia. Mechanistically, inclined directly bind glycolytic enzyme PKM2, leading dramatic decrease glycolysis. More importantly, improved integrity via activating β-Catenin/Claudin-5 signaling axis PKM2-dependent manner. Our findings suggest may serve potent agent for inducing normalization.

Language: Английский

Citations

10
Advances in Doxorubicin-based nano-drug delivery system in triple negative breast cancer DOI Creative Commons
Weiwei Zeng,

Yuning Luo,

Dali Gan

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: Nov. 17, 2023

Triple positive breast cancer (TPBC) is one of the most aggressive cancer. Due to unique cell phenotype, aggressiveness, metastatic potential and lack receptors or targets, chemotherapy choice treatment for TNBC. Doxorubicin (DOX), representative agents anthracycline chemotherapy, has better efficacy in patients with TNBC (mTNBC). DOX anthracycline-based regimens have higher response rates. Nano-drug delivery systems possess targeting ability co-load, deliver release chemotherapeutic drugs, active gene fragments immune enhancing factors effectively inhibit kill tumor cells. Therefore, advances nano-drug therapy attracted a considerable amount attention from researchers. In this article, we reviewed progress (e.g., Nanoparticles, Liposomes, Micelles, Nanogels, Dendrimers, Exosomes, etc.) applied We also summarize current clinical trials combined checkpoint inhibitors (ICIS) The merits, demerits future development nanomedicine are envisioned, aim providing new class safe efficient thoughts

Language: Английский

Citations

18
Evaluation of the effects of a dasatinib-containing, self-emulsifying, drug delivery system on HT29 and SW420 human colorectal carcinoma cells, and MCF7 human breast adenocarcinoma cells DOI Creative Commons

Rehab A Baghdadi,

Ashraf N. Abdalla, Mohammed A. S. Abourehab

et al.

Journal of Taibah University Medical Sciences, Journal Year: 2024, Volume and Issue: 19(4), P. 806 - 815

Published: July 22, 2024

Dasatinib (DS), a second-generation tyrosine kinase inhibitor, functions as multi-target small-molecule drug via targeting various kinases involved in neoplastic cell growth. DS inhibits cancer replication and migration, induces tumor apoptosis variety of solid tumors. However, it is poorly soluble water under some pH values. Therefore, the development DS-containing, self-emulsifying, delivery system (SeDDs) could help overcome these problems treating cells.

Language: Английский

Citations

4