Research Progress of Zebrafish Model in Aquatic Ecotoxicology

Water, Год журнала: 2023, Номер 15(9), С. 1735 - 1735

Опубликована: Апрель 30, 2023

In recent years, with the aggravation of environmental pollution, study aquatic ecotoxicology has become a hot topic. Some organisms, such as large fleas, toads, and zebrafish, have been developed applied model organisms. They increasingly used to bioaccumulation toxicity pollutants due advantages their small size, easy reproduction, short life cycle, low maintenance cost, ability combine genetic, cellular, whole organism endpoints. This review summarizes methods in ecotoxicology, using its developmental toxicity, biomarkers, genomics, phenotype analysis evaluate pollutants, providing reference value for researchers select animals research.

Язык: Английский

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Advances in Zebrafish as a Comprehensive Model of Mental Disorders

Depression and Anxiety, Год журнала: 2023, Номер 2023, С. 1 - 48

Опубликована: Июнь 20, 2023

As an important part in international disease, mental disorders seriously damage human health and social stability, which show the complex pathogenesis increasing incidence year by year. In order to analyze of as soon possible look for targeted drug treatment psychiatric diseases, a more reasonable animal model is imperious demands. Benefiting from its high homology with genome, brain tissue highly similar that humans, it easy realize whole-body optical visualization high-throughput screening; zebrafish stands out among many models disorders. Here, valuable qualified could be established through behavioral test sociological analysis, are simulated combined molecular analyses other detection methods. This review focuses on advances simulate disorders; summarizes various characterization means, use equipment, operation principle; sums up disorder modeling methods; puts forward current challenges future development trend, contribute theoretical supports exploration mechanisms strategies

Язык: Английский

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The therapeutic effects of saikosaponins on depression through the modulation of neuroplasticity: From molecular mechanisms to potential clinical applications

Pharmacological Research, Год журнала: 2024, Номер 201, С. 107090 - 107090

Опубликована: Фев. 2, 2024

Depression is a major global health issue that urgently requires innovative and precise treatment options. In this context, saikosaponin has emerged as promising candidate, offering variety of therapeutic benefits may be effective in combating depression. This review delves into the multifaceted potential saikosaponins alleviating depressive symptoms. We summarized effects on structural functional neuroplasticity, elaborated regulatory mechanism modulating key factors affect such inflammation, hypothalamic-pituitary-adrenal (HPA) axis, oxidative stress, brain-gut axis. Moreover, paper highlights existing gaps current researches outlines directions for future studies. A detailed plan provided clinical application saikosaponins, advocating more targeted to speed up its transition from preclinical trials practice.

Язык: Английский

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Advances in Zebrafish for Diabetes Mellitus with Wound Model

Bioengineering, Год журнала: 2023, Номер 10(3), С. 330 - 330

Опубликована: Март 6, 2023

Diabetic foot ulcers cause great suffering and are costly for the healthcare system. Normal wound healing involves hemostasis, inflammation, proliferation, remodeling. However, negative factors associated with diabetes, such as bacterial biofilms, persistent impaired angiogenesis, inhibited cell pathological scarring, greatly interfere smooth progress of entire process. It is this that leads to diabetic even amputations. Therefore, drug screening challenging due complexity damaged mechanisms. The establishment a scientific reasonable animal experimental model contributes significantly in-depth research pathology, prevention, diagnosis, treatment. In addition low cost transparency embryo (for imaging transgene applications), zebrafish have discrete process separate study each stage, resulting in their potential ideal future. review, we examine reasons behind delayed wounds, systematically review various studies using by different induction methods, well summarize challenges improvement strategies which provide references establishing more model.

Язык: Английский

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Improvement in Zebrafish with Diabetes and Alzheimer's Disease Treated with Pasteurized Akkermansia muciniphila

Microbiology Spectrum, Год журнала: 2023, Номер 11(3)

Опубликована: Май 16, 2023

Diabetes and Alzheimer's disease (AD) are associated with specific changes in the composition of intestinal flora. Studies have shown that supplementation pasteurized Akkermansia muciniphila has therapeutic preventive effects on diabetes. However, it is not clear whether there any association improvement prevention diabetes disease. Here, we found can significantly improve blood glucose, body mass index, indexes zebrafish mellitus complicated also alleviate related The memory, anxiety, aggression, social preference behavior combined type 2 (T2DM) (TA zebrafish) were improved after treatment. Moreover, examined effect results showed group better terms biochemical index than treatment group. These findings provide new ideas for IMPORTANCE interaction between microflora host affects progression As a recognized next-generation probiotic, been to play key role disease, but A. its potential mechanism unclear. In this study, model was established, discussed. pasteurization prevented Treatment preference, aggressive anxiety TA alleviated pathological characteristics T2DM AD. prospect probiotics

Язык: Английский

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Development of a sodium hyaluronate-enriched therapeutic formulation with stevia glycoside and mogroside V for the comprehensive management of diabetes and its complications

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 293, С. 139487 - 139487

Опубликована: Янв. 5, 2025

Язык: Английский

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Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer’s disease: targeting oxidative stress, inflammation, and the gut-brain axis

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 16

Опубликована: Янв. 7, 2025

Alzheimer's disease (AD) is a complex neurodegenerative disorder, with amyloid-beta (Aβ) aggregation playing key role in its pathogenesis. Aβ-induced oxidative stress leads to neuronal damage, mitochondrial dysfunction, and apoptosis, making antioxidative strategies promising for AD treatment. This study investigates the effects of hydrogen-rich water (HRW) zebrafish model. Zebrafish were exposed aluminum chloride induce AD-like pathology then treated HRW using nanobubble device. Behavioral assays, ELISA, Hematoxylin-eosin (H&E) staining, reactive oxygen species (ROS) neutrophil fluorescence labeling employed assess HRW's impact. Additionally, 16S rRNA sequencing analyzed effect on gut microbiota. can significantly improve cognitive impairment depression-like behavior model, reduce Aβ deposition (p < 0.0001), regulate liver Soluble epoxide hydrolase (sEH) levels 0.05), neuroinflammation, stress. Furthermore, reduced number harmful bacteria linked by restoring balance microbiota gut. These findings suggest that has potential as therapeutic strategy targeting stress, inflammation, gut-brain axis modulation.

Язык: Английский

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Exploring the potential of white birch sap: A natural alternative to traditional skin whitening agents with reduced side effects

Heliyon, Год журнала: 2024, Номер 10(5), С. e26715 - e26715

Опубликована: Фев. 27, 2024

Common tyrosinase (TYR) inhibitors used in cosmetics, such as hydroquinone, kojic acid, and arbutin, can cause side effects including erythema, skin peeling, dryness. Therefore, the development of natural whitening agents that offer excellent permeability, minimal irritation, high safety has become a primary focus field TYR inhibitors. In this study, we demonstrate White birch sap (WBS), within safe concentration range, effectively reduces activity melanin content both B16F10 mouse melanoma cells zebrafish larvae. Importantly, WBS exhibits irritation to neutrophils fluorescent does not affect behavior adult zebrafish. Furthermore, downregulates gene expression levels microphthalmia-associated transcription factor, TYR, tyrosinase-related protein-1, protein-2 cells. conclusion, our research confirms WBS, naturally derived substance, offers mild effects, making it promising candidate for skin-whitening agent.

Язык: Английский

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Rapid Assessment of Ocular Toxicity from Environmental Contaminants Based on Visually Mediated Zebrafish Behavior Studies

Toxics, Год журнала: 2023, Номер 11(8), С. 706 - 706

Опубликована: Авг. 16, 2023

The presence of contaminants in the environment has increased recent years, and studies have demonstrated that these ability to penetrate blood–retinal barrier directly affect visual systems organisms. Zebrafish are recognized as an ideal model for human eye diseases due their anatomical functional similarities eye, making them efficient versatile organism studying ocular toxicity caused by environmental field toxicology. Meanwhile, zebrafish exhibit a diverse repertoire visually mediated behaviors, system undergoes complex changes behavioral responses when exposed contaminants, enabling rapid assessment induced such pollutants. Therefore, this review aimed highlight effectiveness examining effects on development. Special attention is given behavior zebrafish, which allows resulting from exposure contaminants. Additionally, potential mechanisms may induce briefly outlined.

Язык: Английский

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Utilizing zebrafish models to elucidate mechanisms and develop therapies for skeletal muscle atrophy

Life Sciences, Год журнала: 2025, Номер unknown, С. 123357 - 123357

Опубликована: Янв. 1, 2025

Язык: Английский

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