Archives of Gerontology and Geriatrics Plus,
Год журнала:
2024,
Номер
1(3), С. 100034 - 100034
Опубликована: Май 7, 2024
The
potential
contributions
of
neuromuscular
junction
(NMJ)
degradation
to
muscle
loss
in
cancer
remain
poorly
understood.
We
investigated
the
biomarkers
NMJ
decline
patients
with
gynecological
carcinomas.
recruited
women
endometrial
(n=37,
56-73
years
old)
or
ovarian
(n=40,
55-72
carcinomas
along
age-matched
controls
(n=47,
55-71
controls,
divided
into
two
subgroups
based
on
presence
age-associated
loss,
termed
sarcopenia.
measured
plasma
c-terminal
agrin-fragment-32
(CAF22;
biomarker
loss),
neurofilament
light
chain
(NF-L;
neurodegeneration),
handgrip
strength
(HGS),
appendicular
skeletal
mass
index
(AMMI),
and
short
physical
performance
battery
(SPPB;
marker
capacity).
Patients
exhibits
low
HGS,
AMMI,
SPPB
higher
NF-L
levels
than
(all
p<0.05).
found
a
modest
elevation
CAF22
but
not
sarcopenia
was
associated
further
levels.
Higher
carcinoma
stages
were
both
groups
patients.
Collectively,
may
have
contribution
strategies
counter
target
intrinsic
changes
within
independent
NMJ.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(9), С. 8237 - 8237
Опубликована: Май 4, 2023
The
pulmonary
endothelium
is
a
highly
regulated
organ
that
performs
wide
range
of
functions
under
physiological
and
pathological
conditions.
Since
endothelial
dysfunction
has
been
demonstrated
to
play
direct
role
in
sepsis
acute
respiratory
distress
syndrome,
its
COVID-19
also
extensively
investigated.
Indeed,
apart
from
the
COVID-19-associated
coagulopathy
biomarkers,
new
biomarkers
were
recognised
early
during
pandemic,
including
markers
cell
activation
or
injury.
We
systematically
searched
literature
up
10
March
2023
for
studies
examining
association
between
long
severity
outcomes
biomarkers.
Bratislavské lekárske listy/Bratislava medical journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 30, 2025
Abstract
Background
The
coronavirus
disease
2019
(COVID-19)
has
highly
impacted
everyday
lives
and
healthcare
systems
since
its
spread
across
the
globe.
As
a
result
of
numerous
mutations
in
viral
genome,
several
genetic
variants
sub-variants
have
evolved,
they
differ
various
characteristics,
such
as
infectivity,
transmissibility,
immune
response
human
body.
aim
this
study
was
to
compare
cytokine
levels
plasma
samples
from
patients
with
acute
COVID-19,
infected
either
Delta
or
Omicron
variants.
Methods
This
retrospective
included
80
hospitalized
PCR-confirmed
SARS-CoV-2.
Blood
well
control
subjects
were
collected,
multiplex
assay
performed
determining
48
cytokines
plasma.
Results
50
Delta,
30
variant,
18
subjects.
Severe
critical
course
led
27
significantly
modified
both
COVID-19
compared
However,
12
(GRO-α,
IFN-α2,
IL-1α,
IL-4,
IL-9,
IL-16,
MIF,
MIP-1β,
SDF-1α,
TNF-α,
TNF-β,
TRAIL)
elevated
versus
variant
discrimination
equal
AUC
=
0.876.
Moreover,
vaccination
decreased
GM-CSF,
IL-7,
IL-8
variant.
Conclusions
suggests
that
SARS-CoV-2
affect
differently.
Journal of Alzheimer s Disease,
Год журнала:
2023,
Номер
94(2), С. 641 - 650
Опубликована: Июнь 13, 2023
Hypertension
and
skeletal
muscle
decline
are
common
findings
in
patients
with
Alzheimer's
disease
(AD).
Angiotensin-converting
enzyme
(ACE)
inhibitors
preserve
physical
capacity;
however,
the
driving
mechanisms
poorly
understood.We
investigated
effects
of
ACE
on
neuromuscular
junction
(NMJ)
relevance
to
capacity
AD
age-matched
controls.We
evaluated
controls
(n
=
59)
three
groups
patients,
including
normotensive
51)
hypertension
taking
53)
or
other
anti-hypertensive
medications
49)
at
baseline
one
year
later.
We
measure
plasma
c-terminal
agrin
fragment-22
(CAF22)
as
a
marker
NMJ
degradation,
handgrip
strength
(HGS),
Short
Physical
Performance
Battery
(SPPB)
markers
capacity.At
demonstrated
lower
HGS
SPPB
scores
higher
CAF22
levels
than
controls,
irrespective
status
(all
p
<
0.05).
The
use
was
associated
relative
maintenance
scores,
gait
speed,
levels.
Conversely,
were
an
unaltered
HGS,
reduced
elevated
(both
also
found
dynamic
associations
These
changes
oxidative
stress
(p
0.05).Altogether,
preserved
capacity,
prevention
degradation
hypertensive
patients.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Янв. 25, 2024
The
pathobiology
of
respiratory
failure
in
COVID-19
consists
a
complex
interplay
between
viral
cytopathic
effects
and
dysregulated
host
immune
response.
In
critically
ill
patients,
imatinib
treatment
demonstrated
potential
for
reducing
invasive
ventilation
duration
mortality.
Here,
we
perform
longitudinal
profiling
6385
plasma
proteins
318
hospitalised
patients
to
investigate
the
biological
processes
involved
critical
COVID-19,
assess
treatment.
Nine
measured
at
hospital
admission
accurately
predict
illness
development.
Next
dysregulation
inflammation,
is
characterised
by
pathways
involving
cellular
adhesion,
extracellular
matrix
turnover
tissue
remodelling.
Imatinib
attenuates
protein
perturbations
associated
with
inflammation
turnover.
These
proteomic
alterations
are
contextualised
using
external
pulmonary
RNA-sequencing
data
deceased
imatinib-treated
Syrian
hamsters.
Together,
show
that
alveolar
capillary
barrier
disruption
reflected
proteome,
attenuated
This
study
comprises
secondary
analysis
both
clinical
samples
derived
from
trial
was
registered
EU
Clinical
Trials
Register
(EudraCT
2020-001236-10,
https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001236-10/NL
)
Netherlands
Trial
(NL8491,
https://www.trialregister.nl/trial/8491
).
Frontiers in Medicine,
Год журнала:
2023,
Номер
10
Опубликована: Июль 6, 2023
The
disease
COVID-19,
caused
by
SARS-CoV-2
infection,
has
a
systemic
effect
and
is
associated
with
number
of
pathophysiological
mechanisms
that
mobilize
wide
range
biomolecules.
Cytokines
growth
factors
(GFs)
are
critical
regulators
tissue
damage
or
repair
in
osteoarthritis
(OA)
being
recognized
as
key
players
the
pathogenesis
COVID-19.
A
clear
understanding
long-term
consequences
especially
patients
concomitant
chronic
diseases,
limited
needs
to
be
elucidated.
study
aimed
evaluate
degree
inflammation
levels
pro-angiogenic
hypoxic
factors,
well
heat
shock
proteins
HSP60
HSP70
plasma,
OA
after
recovery
from
COVID-19.The
research
involved
an
orthopedic
specialty
clinic
aged
39
80
diagnosed
knee
OA.
All
examined
were
divided
into
three
groups:
Control
group
included
conditionally
healthy
donors,
mainly
stage
II
III
COVID-19
who
had
plasma
pro-inflammatory
molecules
IL-1β,
IL-6,
TNF-α,
NF-κB,
angiogenic
VEGF,
FGF-2,
PDGF,
factor
HIF-1α
molecular
chaperones
measured
enzyme-linked
immunosorbent
assay.The
showed
both
groups
patients,
convalescent
there
was
increase
level
IL-1β
decrease
TNF-α
NF-κB
when
compared
controls.
Systemic
deregulation
cytokine
profile
accompanied
reduction
most
pronounced
cases
VEGF
PDGF.
This
analysis
did
not
reveal
any
significant
difference
HIF-1α.
stress
protein
blood
OA,
those
have
been
established.The
results
suggest
potential
role
cytokines
angiogenesis-related
joint
pathologies
post-COVID-19
disorders.
