Association of neuromuscular disjunction with cachexia in patients with gynecological cancers DOI Creative Commons
Rizwan Qaisar, Shah S. Hussain, Asima Karim

et al.

Archives of Gerontology and Geriatrics Plus, Journal Year: 2024, Volume and Issue: 1(3), P. 100034 - 100034

Published: May 7, 2024

The potential contributions of neuromuscular junction (NMJ) degradation to muscle loss in cancer remain poorly understood. We investigated the biomarkers NMJ decline patients with gynecological carcinomas. recruited women endometrial (n=37, 56-73 years old) or ovarian (n=40, 55-72 carcinomas along age-matched controls (n=47, 55-71 controls, divided into two subgroups based on presence age-associated loss, termed sarcopenia. measured plasma c-terminal agrin-fragment-32 (CAF22; biomarker loss), neurofilament light chain (NF-L; neurodegeneration), handgrip strength (HGS), appendicular skeletal mass index (AMMI), and short physical performance battery (SPPB; marker capacity). Patients exhibits low HGS, AMMI, SPPB higher NF-L levels than (all p<0.05). found a modest elevation CAF22 but not sarcopenia was associated further levels. Higher carcinoma stages were both groups patients. Collectively, may have contribution strategies counter target intrinsic changes within independent NMJ.

Language: Английский

Endotheliopathy in Acute COVID-19 and Long COVID DOI Open Access
Alice G. Vassiliou, Charikleia S. Vrettou, Chrysi Keskinidou

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8237 - 8237

Published: May 4, 2023

The pulmonary endothelium is a highly regulated organ that performs wide range of functions under physiological and pathological conditions. Since endothelial dysfunction has been demonstrated to play direct role in sepsis acute respiratory distress syndrome, its COVID-19 also extensively investigated. Indeed, apart from the COVID-19-associated coagulopathy biomarkers, new biomarkers were recognised early during pandemic, including markers cell activation or injury. We systematically searched literature up 10 March 2023 for studies examining association between long severity outcomes biomarkers.

Language: Английский

Citations

31
Probiotics Supplements Improve the Sarcopenia-Related Quality of Life in Older Adults with Age-Related Muscle Decline DOI
Rizwan Qaisar,

Ayousha Burki,

Asima Karim

et al.

Calcified Tissue International, Journal Year: 2024, Volume and Issue: 114(6), P. 583 - 591

Published: April 20, 2024

Language: Английский

Citations

10
Comparative Study of Cytokine Profiles in SARS-CoV-2 Delta and Omicron Variants DOI Open Access
Michaela Krivosova, Juliana Hanusrichterová, Vincent Lučanský

et al.

Bratislavské lekárske listy/Bratislava medical journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Abstract Background The coronavirus disease 2019 (COVID-19) has highly impacted everyday lives and healthcare systems since its spread across the globe. As a result of numerous mutations in viral genome, several genetic variants sub-variants have evolved, they differ various characteristics, such as infectivity, transmissibility, immune response human body. aim this study was to compare cytokine levels plasma samples from patients with acute COVID-19, infected either Delta or Omicron variants. Methods This retrospective included 80 hospitalized PCR-confirmed SARS-CoV-2. Blood well control subjects were collected, multiplex assay performed determining 48 cytokines plasma. Results 50 Delta, 30 variant, 18 subjects. Severe critical course led 27 significantly modified both COVID-19 compared However, 12 (GRO-α, IFN-α2, IL-1α, IL-4, IL-9, IL-16, MIF, MIP-1β, SDF-1α, TNF-α, TNF-β, TRAIL) elevated versus variant discrimination equal AUC = 0.876. Moreover, vaccination decreased GM-CSF, IL-7, IL-8 variant. Conclusions suggests that SARS-CoV-2 affect differently.

Language: Английский

Citations

1
ACE Inhibitors Improve Skeletal Muscle by Preserving Neuromuscular Junctions in Patients with Alzheimer’s Disease DOI
Rizwan Qaisar, Asima Karim, M. Shahid Iqbal

et al.

Journal of Alzheimer s Disease, Journal Year: 2023, Volume and Issue: 94(2), P. 641 - 650

Published: June 13, 2023

Hypertension and skeletal muscle decline are common findings in patients with Alzheimer's disease (AD). Angiotensin-converting enzyme (ACE) inhibitors preserve physical capacity; however, the driving mechanisms poorly understood.We investigated effects of ACE on neuromuscular junction (NMJ) relevance to capacity AD age-matched controls.We evaluated controls (n = 59) three groups patients, including normotensive 51) hypertension taking 53) or other anti-hypertensive medications 49) at baseline one year later. We measure plasma c-terminal agrin fragment-22 (CAF22) as a marker NMJ degradation, handgrip strength (HGS), Short Physical Performance Battery (SPPB) markers capacity.At demonstrated lower HGS SPPB scores higher CAF22 levels than controls, irrespective status (all p < 0.05). The use was associated relative maintenance scores, gait speed, levels. Conversely, were an unaltered HGS, reduced elevated (both also found dynamic associations These changes oxidative stress (p 0.05).Altogether, preserved capacity, prevention degradation hypertensive patients.

Language: Английский

Citations

17
Longitudinal plasma proteomics reveals biomarkers of alveolar-capillary barrier disruption in critically ill COVID-19 patients DOI Creative Commons
Erik Duijvelaar, Jack Gisby, James E. Peters

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 25, 2024

The pathobiology of respiratory failure in COVID-19 consists a complex interplay between viral cytopathic effects and dysregulated host immune response. In critically ill patients, imatinib treatment demonstrated potential for reducing invasive ventilation duration mortality. Here, we perform longitudinal profiling 6385 plasma proteins 318 hospitalised patients to investigate the biological processes involved critical COVID-19, assess treatment. Nine measured at hospital admission accurately predict illness development. Next dysregulation inflammation, is characterised by pathways involving cellular adhesion, extracellular matrix turnover tissue remodelling. Imatinib attenuates protein perturbations associated with inflammation turnover. These proteomic alterations are contextualised using external pulmonary RNA-sequencing data deceased imatinib-treated Syrian hamsters. Together, show that alveolar capillary barrier disruption reflected proteome, attenuated This study comprises secondary analysis both clinical samples derived from trial was registered EU Clinical Trials Register (EudraCT 2020-001236-10, https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001236-10/NL ) Netherlands Trial (NL8491, https://www.trialregister.nl/trial/8491 ).

Language: Английский

Citations

8
Metformin Improves Sarcopenia-Related Quality of Life in Geriatric Adults: A Randomized Controlled Trial DOI
Rizwan Qaisar, Asima Karim, Tahir Muhammad

et al.

Archives of Medical Research, Journal Year: 2024, Volume and Issue: 55(4), P. 102998 - 102998

Published: April 13, 2024

Language: Английский

Citations

8
Plasma zonulin correlates with cardiac dysfunction and poor physical performance in patients with chronic heart failure DOI
Firdos Ahmad, Asima Karim,

Javaidullah Khan

et al.

Life Sciences, Journal Year: 2022, Volume and Issue: 311, P. 121150 - 121150

Published: Nov. 3, 2022

Language: Английский

Citations

28
Changes in chemokine and growth factor levels may be useful biomarkers for monitoring disease severity in COVID-19 patients; a pilot study DOI Creative Commons
Blanka Wolszczak-Biedrzycka, Justyna Dorf, Marzena Wojewódzka‐Żeleźniakowicz

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 4, 2024

Aim The aim of the present study was to assess differences in serum levels chemokines and growth factors (GFs) between COVID-19 patients healthy controls. diagnostic utility analyzed proteins for monitoring severity SARS-CoV- 2 infection based on patients’ MEWS scores also assessed. Materials methods were hospitalized (50 women, 50 men) with use Bio-Plex Pro™ Human Cytokine Screening Panel (Biorad) Multiplex system. Results demonstrated that MIP-1α, RANTES, Eotaxin, CTACK, GRO-α, IP-10, MIG, basic-FGF, HGF, SCGF-β, G-CSF, M-CSF, SCF, MIF, LIF, TRAIL significant higher than control group. concentrations PDGF- BB, GM-CSF, asymptomatic/mildly symptomatic (stage 1) pneumonia without respiratory failure 2). receiver operating characteristic (ROC) analysis revealed basic-FGF differentiated from controls highest sensitivity specificity, whereas MIG 2) specificity. Conclusions GM-CSF can be useful biomarkers disease COVID-19.

Language: Английский

Citations

5
Lipid-Lowering Medications are Associated with Reduced Sarcopenia-Related Quality of Life in Older Adults with Hyperlipidemia DOI
Rizwan Qaisar,

Imran M. Khan,

Asima Karim

et al.

Drugs & Aging, Journal Year: 2024, Volume and Issue: 41(5), P. 443 - 453

Published: April 2, 2024

Language: Английский

Citations

5
Circulating levels of inflammatory cytokines and angiogenesis-related growth factors in patients with osteoarthritis after COVID-19 DOI Creative Commons
Daryna Krenytska, Kateryna Strubchevska, Marko Kozyk

et al.

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: July 6, 2023

The disease COVID-19, caused by SARS-CoV-2 infection, has a systemic effect and is associated with number of pathophysiological mechanisms that mobilize wide range biomolecules. Cytokines growth factors (GFs) are critical regulators tissue damage or repair in osteoarthritis (OA) being recognized as key players the pathogenesis COVID-19. A clear understanding long-term consequences especially patients concomitant chronic diseases, limited needs to be elucidated. study aimed evaluate degree inflammation levels pro-angiogenic hypoxic factors, well heat shock proteins HSP60 HSP70 plasma, OA after recovery from COVID-19.The research involved an orthopedic specialty clinic aged 39 80 diagnosed knee OA. All examined were divided into three groups: Control group included conditionally healthy donors, mainly stage II III COVID-19 who had plasma pro-inflammatory molecules IL-1β, IL-6, TNF-α, NF-κB, angiogenic VEGF, FGF-2, PDGF, factor HIF-1α molecular chaperones measured enzyme-linked immunosorbent assay.The showed both groups patients, convalescent there was increase level IL-1β decrease TNF-α NF-κB when compared controls. Systemic deregulation cytokine profile accompanied reduction most pronounced cases VEGF PDGF. This analysis did not reveal any significant difference HIF-1α. stress protein blood OA, those have been established.The results suggest potential role cytokines angiogenesis-related joint pathologies post-COVID-19 disorders.

Language: Английский

Citations

13