Flavonoids: Overview of Biosynthesis, Biological Activity, and Current Extraction Techniques

Plants, Год журнала: 2023, Номер 12(14), С. 2732 - 2732

Опубликована: Июль 23, 2023

Recently, increased attention has been paid to natural sources as raw materials for the development of new added-value products. Flavonoids are a large family polyphenols which include several classes based on their basic structure: flavanones, flavones, isoflavones, flavonols, flavanols, and anthocyanins. They have multitude biological properties, such anti-inflammatory, antioxidant, antiviral, antimicrobial, anticancer, cardioprotective, neuroprotective effects. Current trends research flavonoids relate identification, extraction, isolation, physico-chemical characterization, applications health benefits. This review presents an up-to-date survey most recent developments in flavonoid classes, activity representative flavonoids, current extraction techniques, perspectives.

Язык: Английский

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Opportunities and challenges in enhancing the bioavailability and bioactivity of dietary flavonoids: A novel delivery system perspective

Food Chemistry, Год журнала: 2023, Номер 430, С. 137115 - 137115

Опубликована: Авг. 7, 2023

Язык: Английский

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Cryopreservation of bioflavonoid-rich plant sources and bioflavonoid-microcapsules: emerging technologies for preserving bioactivity and enhancing nutraceutical applications

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Сен. 14, 2023

Bioflavonoids are natural polyphenolic secondary metabolites that medicinal. These compounds possess antitumor, cardioprotective, anti-inflammatory, antimicrobial, antiviral, and anti-psoriasis properties to mention a few. Plant species contain bioflavonoids should be preserved as such. Also, the bioactivity of neutraceutical is compromised following extraction due their sensitivity environmental factors like light, pH, temperature. In other words, bioflavonoids’ shelf-life affected. Scientists noticed have low solubility properties, poor absorption, bioavailability consumption. Researchers came up with methods encapsulate in order circumvent challenges above also mask unpleasant these chemicals may have. Besides, scientists cryopreserve plant bioflavonoids. this review, we discuss cryopreservation bioflavonoid microencapsulation focusing mainly on vitrification, slow freezing, freeze-drying techniques. addition, highlight techniques, medicinal challenges, future perspectives Regardless uniqueness preserve sources bioactivity, there reported. Freeze-drying technology costly. Cryoprotectants damage integrity cells, say least. working very hard overcome challenges. Encapsulating via coaxial electrospray then cryopreserving micro/nanocapsules produced can interesting.

Язык: Английский

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Polyphenol-Loaded Nano-carriers for Breast Cancer Therapy: A Comprehensive Review

BioNanoScience, Год журнала: 2024, Номер 14(4), С. 4219 - 4237

Опубликована: Янв. 10, 2024

Язык: Английский

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Botanical Flavonoids: Efficacy, Absorption, Metabolism and Advanced Pharmaceutical Technology for Improving Bioavailability

Molecules, Год журнала: 2025, Номер 30(5), С. 1184 - 1184

Опубликована: Март 6, 2025

Flavonoids represent a class of natural plant secondary metabolites with multiple activities including antioxidant, antitumor, anti-inflammatory, and antimicrobial properties. However, due to their structural characteristics, they often exhibit low bioavailability in vivo. In this review, we focus on the vivo study flavonoids, particularly effects gut microbiome common modifications such as methylation, acetylation, dehydroxylation, etc. These aim change characteristics original substances enhance absorption bioavailability. order improve discuss two feasible methods, namely dosage form modification chemical modification, hope that these approaches will offer new insights into application flavonoids for human health. article, also introduce types, sources, efficacy flavonoids. conclusion, is comprehensive review how

Язык: Английский

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The therapeutic role of naringenin nanoparticles on hepatocellular carcinoma

BMC Pharmacology and Toxicology, Год журнала: 2025, Номер 26(1)

Опубликована: Янв. 3, 2025

Abstract Background Naringenin, a flavonoid compound found in citrus fruits, possesses valuable anticancer properties. However, its potential application cancer treatment is limited by poor bioavailability and pharmacokinetics at tumor sites. To address this, Naringenin nanoparticles (NARNPs) were prepared using the emulsion diffusion technique their effects investigated HepG2 cells. Methods The particle size of NARNPs was determined transmission electron microscopy scanning analysis. NARNP characterized Fourier transform infrared spectroscopy X-ray diffraction. Study cytotoxic various doses naringenin, DOX on WI38 cell lines after 24 h 48 MTT assay. Flow cytometric analysis used to study apoptotic also examined expression proteins (p53) autophagy-related genes ATG5, LC3 with NARNPs, doxorubicin, combinations Results analysis, showing mean diameters 54.96 ± 18.6 nm 31.79 6.8 nm, respectively. confirmed successful conjugation between naringenin NARNPs. an amorphous state that IC50 values as 22.32 µg/ml for 1.6 0.46 doxorubicin. showed induced late apoptosis 56.1% cells had no effect 97% viable incubation. cycle arrest Go/G1 G2/M phases results increased LC3, p53 treated concentrations enhanced doxorubicin but decreased Conclusions demonstrated effectively inhibit proliferation induce human hepatocellular carcinoma Importantly, normal cells, indicating promising therapy hepatocarcinogenesis. Combining chemotherapy drugs could present novel approach treating cancers.

Язык: Английский

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Berberine for gastric cancer prevention and treatment: Multi-step actions on the Correa’s cascade underlie its therapeutic effects

Pharmacological Research, Год журнала: 2022, Номер 184, С. 106440 - 106440

Опубликована: Сен. 13, 2022

Язык: Английский

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Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer

Antioxidants, Год журнала: 2023, Номер 12(3), С. 586 - 586

Опубликована: Фев. 27, 2023

Citrus (genus L.) fruits are essential sources of bioactive compounds with antioxidant properties, such as flavonoids. These polyphenolic divided into subclasses, in which flavanones the most prominent. Among them, naringenin and hesperidin emerging anticancer potential, especially for breast cancer (BC). Several mechanisms have been proposed, including modulation epigenetics, estrogen signaling, induction cell death via regulation apoptotic signaling pathways, inhibition tumor invasion metastasis. However, this information is sparse literature needs to be brought together provide an overview how can serve therapeutic tools drug development a successful co-adjuvant strategy against BC. This review detailed context highlighted could interfere BC carcinogenesis helpful potential alternative treatment.

Язык: Английский

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Insight into the Biological Roles and Mechanisms of Phytochemicals in Different Types of Cancer: Targeting Cancer Therapeutics

Nutrients, Год журнала: 2023, Номер 15(7), С. 1704 - 1704

Опубликована: Март 31, 2023

Cancer is a hard-to-treat disease with high reoccurrence rate that affects health and lives globally. The condition has occurrence the second leading cause of mortality after cardiovascular disorders. Increased research more profound knowledge mechanisms contributing to disease’s onset progression have led drug discovery development. Various drugs are on market against cancer; however, face challenges chemoresistance. other major problem side effects these drugs. Therefore, using complementary additional medicines from natural sources best strategy overcome issues. naturally occurring phytochemicals vast source novel various ailments. modes action by which show their anti-cancer can be induction apoptosis, cell cycle arrest, kinase inhibition, blocking carcinogens. This review aims describe different phytochemicals, classification, role as agents, mode in types cancer.

Язык: Английский

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Mechanisms of ferroptosis regulating oxidative stress and energy metabolism in myocardial ischemia-reperfusion injury and a novel perspective of natural plant active ingredients for its treatment

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 165, С. 114706 - 114706

Опубликована: Июль 1, 2023

Acute myocardial infarction remains the leading cause of death in humans. Timely restoration blood perfusion to ischemic myocardium most effective strategy treatment acute infarction, which can significantly reduce morbidity and mortality. However, after flow reperfusion, injury will aggravate induce apoptosis cardiomyocytes, a process called ischemia-reperfusion injury. Studies have shown that loss cardiomyocytes caused by oxidative stress, iron load, increased lipid peroxidation, inflammation mitochondrial dysfunction, etc., are involved In recent years, with in-depth research on pathology injury, people gradually realized there is new form cell pathological namely ferroptosis. A number studies found tissue patients changes closely related ferroptosis, such as metabolism disorder, reactive oxygen species free radicals. Natural plant products resveratrol, baicalin, cyanidin-3-O-glucoside, naringenin, astragaloside IV also exert therapeutic effects correcting imbalance these ferroptosis-related factors expression levels. Combining our previous studies, this review summarizes regulatory mechanism natural intervening ferroptosis order provide reference information for development targeted inhibitor drugs cardiovascular diseases.

Язык: Английский

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