Helicobacter pylori infection: a dynamic process from diagnosis to treatment

Frontiers in Cellular and Infection Microbiology, Год журнала: 2023, Номер 13

Опубликована: Окт. 19, 2023

, a gram-negative microaerophilic pathogen, causes several upper gastrointestinal diseases, such as chronic gastritis, peptic ulcer disease, and gastric cancer. For the diseases listed above,

Язык: Английский

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Reshaping the immune microenvironment and reversing immunosenescence by natural products: prospects for immunotherapy in gastric cancer

Seminars in Cancer Biology, Год журнала: 2025, Номер 110, С. 1 - 16

Опубликована: Фев. 8, 2025

Язык: Английский

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Exosomes-regulated lipid metabolism in tumorigenesis and cancer progression

Cytokine & Growth Factor Reviews, Год журнала: 2023, Номер 73, С. 27 - 39

Опубликована: Май 24, 2023

Язык: Английский

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A review of signal pathway induced by virulent protein CagA of Helicobacter pylori

Frontiers in Cellular and Infection Microbiology, Год журнала: 2023, Номер 13

Опубликована: Апрель 14, 2023

Gastric cancer (GC), a common and high-mortality disease, still occupies an important position in current research, Helicobacter pylori ( H. ) infection as its risk factor has been hot challenging research area. Among the numerous pathogenic factors of , virulence protein CagA widely studied only bacterial-derived oncoprotein. It was found that entering into gastric epithelial cells (GECs) can induce dysregulation multiple cellular pathways such MAPK signaling pathway, PI3K/Akt NF-κB Wnt/β-catenin JAK-STAT Hippo pathway through phosphorylation non-phosphorylation. These disordered cause pathological changes morphology, adhesion, polarity, proliferation, movement, other processes GECs, which eventually promotes occurrence GC. With deepening -related on CagA-induced abnormal updated deepened to some extent, so key activated by are used main stem sort out pathogenesis this paper, aiming provide new strategies for treatment GC future.

Язык: Английский

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Effect of Helicobacter pylori eradication on gastric precancerous lesions: A systematic review and meta‐analysis

Helicobacter, Год журнала: 2023, Номер 28(6)

Опубликована: Авг. 21, 2023

Abstract Background The question of whether eradication Helicobacter pylori (Hp) can reverse gastric precancerous lesions, including intestinal metaplasia, remains uncertain, leading to ongoing debate. Therefore, a meta‐analysis was performed evaluate the effect Hp on lesions. Materials and Methods PubMed, Embase, Cochrane Library, Web Science, Scopus database, ClinicalTrials.gov were systematically searched from inception April 2023 for studies that explored impact Risk ratios (RRs) their 95% confidence intervals (95% CIs) selected as size. We used random‐effects model assess pooled data. also quality assessments, subgroup analyses, sensitivity analyses. Results Fifteen included. Compared with placebo, could significantly prevent progression lesions (RR = 0.87, CI: 0.81–0.94, p < 0.01) them 1.32, 1.17–1.50, 0.01). Then, specific further explored. metaplasia prevented by compared placebo or no treatment 0.80, 0.69–0.94, Moreover, treatment, improved chronic atrophic gastritis 1.84, 1.30–2.61, 1.41, 1.15–1.73, However, in terms preventing dysplasia 0.86, 0.37–2.00) improving 0.89, 0.47–1.70), had advantage treatment. Conclusions therapy them. Notably, be reversed, but this may only appropriate patients epigenetic alterations milder

Язык: Английский

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Polyphenol-Loaded Nano-carriers for Breast Cancer Therapy: A Comprehensive Review

BioNanoScience, Год журнала: 2024, Номер 14(4), С. 4219 - 4237

Опубликована: Янв. 10, 2024

Язык: Английский

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Berberine alleviates neuroinflammation by downregulating NFκB/LCN2 pathway in sepsis-associated encephalopathy: network pharmacology, bioinformatics, and experimental validation

International Immunopharmacology, Год журнала: 2024, Номер 133, С. 112036 - 112036

Опубликована: Апрель 18, 2024

Язык: Английский

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Traditional Chinese medicine for chronic atrophic gastritis: Efficacy, mechanisms and targets

World Journal of Gastroenterology, Год журнала: 2025, Номер 31(9)

Опубликована: Фев. 18, 2025

Chronic atrophic gastritis (CAG) is an important stage of precancerous lesions gastric cancer. Effective treatment and regulation CAG are essential to prevent its progression malignancy. Traditional Chinese medicine (TCM) has shown multi-targeted efficacy in treatment, with advantages enhancing mucosal barrier defense, improving microcirculation, modulating inflammatory immune responses, promoting lesion healing, etc. Clinical studies meta-analyses indicate that TCM provides significant benefits, specific herbal compounds monomers demonstrating protective effects on the mucosa through mechanisms including anti-inflammation, anti-oxidation, cellular proliferation apoptosis, Finally, it pointed out requires standardized research unified standards, constantly clarifies improves evaluation criteria each dimension function.

Язык: Английский

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Emerging trends and research foci of berberine on tumor from 2002 to 2021: A bibliometric article of the literature from WoSCC

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Март 3, 2023

Background: Cancer, also known as a malignant tumor, is caused by the activation of oncogenes, which leads to uncontrolled proliferation cells that results in swelling. According World Health Organization (WHO), cancer one main causes death worldwide. The variables limiting efficacy anti-tumor treatments are side effects and drug resistance. search for natural, safe, low toxicity, efficient chemical compounds tumor research essential. Berberine pentacyclic isoquinoline quaternary ammonium alkaloid isolated from Berberis Coptis has long been used clinical settings. Studies recent years have reported use berberine treatment. In this study, we performed bibliometric analysis berberine- tumor-related research. Materials methods: Relevant articles January 1, 2002, December 31, 2021, were identified Web Science Core Collection (WOSCC) Clarivate Analytics. Microsoft Excel, CiteSpace, VOSviewer, an online platform literary metrology analysis. Results: A total 1368 publications had unique characteristics. Publications China most common (783 articles), Y. B. Feng (from China) was productive author, with highest citations. Medical University (Taiwan) Sun Yat-sen (China) two organizations largest numbers (36 each). Frontiers Pharmacology commonly occurring journal (29 articles). present body focused on mechanism, molecular docking, oxidative stress tumors. Conclusion: Research tumors thoroughly reviewed using knowledge map methods. study reveal dynamic evolution provide basis strategic planning

Язык: Английский

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Berberine: An inspiring resource for the treatment of colorectal diseases

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 167, С. 115571 - 115571

Опубликована: Сен. 25, 2023

Colorectal cancer is a prevalent malignant tumor with complex and diverse pathogenesis. In recent years, natural products have shown promising application prospects as sources of anticancer drugs. BBR, class benzoquinoline alkaloids extracted from various plants, widely used in disease treatments owing to its pharmacological activities, including antibacterial, anti-inflammatory, antioxidant, anticancer, anti-angiogenesis properties. Research has demonstrated that BBR exerts an anti-Salmonella -Escherichia coli infection effect, attenuating inflammatory reactions by inhibiting harmful bacteria. During the stage colorectal precancerous lesions, inhibits activity cell cyclin regulating PI3K/AKT, MAPK, Wnt signaling pathways, thereby decelerating cycle progression polyp or adenoma cells. Moreover, inhibitory effect on primarily occurs through regulation cycle, anti-angiogenesis, gut microbiota, antioxidant pathways. The specific involved pathways include MPK/ERK, NF-kB, EGFR encompassing Bcl-2 family proteins, vascular endothelial growth factor, superoxide dismutase. This study reviews summarizes, for first time, mechanisms action carcinogenesis process cancer, providing novel insights clinical intestinal diseases.

Язык: Английский

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