Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Дек. 24, 2024
Gastric
cancer
remains
a
significant
health
burden
globally,
especially
prevalent
in
Asian
and
European
regions.
Despite
notable
decline
incidence
the
United
States
Western
Europe
over
recent
decades,
disease's
persistence
underscores
urgency
for
advanced
research
its
pathogenesis
treatment
strategies.
Central
to
this
pursuit
is
exploration
of
mitogen-activated
protein
kinase
(MAPK)
pathway,
pivotal
cellular
mechanism
implicated
complex
processes
gastric
development,
including
proliferation,
invasion,
migration,
metastasis.
The
MAPK
or
extracellular
signal-regulated
pathway
serves
as
crucial
conduit
transmitting
signals
elicit
intracellular
responses,
with
signaling
cascades
subject
alterations
due
genetic
epigenetic
variations
across
various
diseases,
prominently
cancer.
This
review
delves
into
intricate
role
cancer,
drawing
upon
most
critical
studies
that
shed
light
on
gateway
disease.
It
highlights
pathway's
involvement
Helicobacter
pylori-mediated
carcinogenesis
tumorigenic
induced
by
Epstein-Barr
virus,
showcasing
substantial
influence
miRNAs
lncRNAs
modulating
cancer's
biological
properties
through
their
interaction
pathway.
Furthermore,
extends
therapeutic
arena,
discussing
promising
impacts
herbal
medicines,
inhibitors,
immunosuppressants
mitigating
progression.
Through
an
exhaustive
examination
multifaceted
from
molecular
crosstalks
prospects,
aspires
contribute
ongoing
efforts
understanding
combating
global
challenge,
paving
way
novel
interventions
improved
patient
outcomes.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Окт. 19, 2023
,
a
gram-negative
microaerophilic
pathogen,
causes
several
upper
gastrointestinal
diseases,
such
as
chronic
gastritis,
peptic
ulcer
disease,
and
gastric
cancer.
For
the
diseases
listed
above,
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Апрель 14, 2023
Gastric
cancer
(GC),
a
common
and
high-mortality
disease,
still
occupies
an
important
position
in
current
research,
Helicobacter
pylori
(
H.
)
infection
as
its
risk
factor
has
been
hot
challenging
research
area.
Among
the
numerous
pathogenic
factors
of
,
virulence
protein
CagA
widely
studied
only
bacterial-derived
oncoprotein.
It
was
found
that
entering
into
gastric
epithelial
cells
(GECs)
can
induce
dysregulation
multiple
cellular
pathways
such
MAPK
signaling
pathway,
PI3K/Akt
NF-κB
Wnt/β-catenin
JAK-STAT
Hippo
pathway
through
phosphorylation
non-phosphorylation.
These
disordered
cause
pathological
changes
morphology,
adhesion,
polarity,
proliferation,
movement,
other
processes
GECs,
which
eventually
promotes
occurrence
GC.
With
deepening
-related
on
CagA-induced
abnormal
updated
deepened
to
some
extent,
so
key
activated
by
are
used
main
stem
sort
out
pathogenesis
this
paper,
aiming
provide
new
strategies
for
treatment
GC
future.
Abstract
Background
The
question
of
whether
eradication
Helicobacter
pylori
(Hp)
can
reverse
gastric
precancerous
lesions,
including
intestinal
metaplasia,
remains
uncertain,
leading
to
ongoing
debate.
Therefore,
a
meta‐analysis
was
performed
evaluate
the
effect
Hp
on
lesions.
Materials
and
Methods
PubMed,
Embase,
Cochrane
Library,
Web
Science,
Scopus
database,
ClinicalTrials.gov
were
systematically
searched
from
inception
April
2023
for
studies
that
explored
impact
Risk
ratios
(RRs)
their
95%
confidence
intervals
(95%
CIs)
selected
as
size.
We
used
random‐effects
model
assess
pooled
data.
also
quality
assessments,
subgroup
analyses,
sensitivity
analyses.
Results
Fifteen
included.
Compared
with
placebo,
could
significantly
prevent
progression
lesions
(RR
=
0.87,
CI:
0.81–0.94,
p
<
0.01)
them
1.32,
1.17–1.50,
0.01).
Then,
specific
further
explored.
metaplasia
prevented
by
compared
placebo
or
no
treatment
0.80,
0.69–0.94,
Moreover,
treatment,
improved
chronic
atrophic
gastritis
1.84,
1.30–2.61,
1.41,
1.15–1.73,
However,
in
terms
preventing
dysplasia
0.86,
0.37–2.00)
improving
0.89,
0.47–1.70),
had
advantage
treatment.
Conclusions
therapy
them.
Notably,
be
reversed,
but
this
may
only
appropriate
patients
epigenetic
alterations
milder
World Journal of Gastroenterology,
Год журнала:
2025,
Номер
31(9)
Опубликована: Фев. 18, 2025
Chronic
atrophic
gastritis
(CAG)
is
an
important
stage
of
precancerous
lesions
gastric
cancer.
Effective
treatment
and
regulation
CAG
are
essential
to
prevent
its
progression
malignancy.
Traditional
Chinese
medicine
(TCM)
has
shown
multi-targeted
efficacy
in
treatment,
with
advantages
enhancing
mucosal
barrier
defense,
improving
microcirculation,
modulating
inflammatory
immune
responses,
promoting
lesion
healing,
etc.
Clinical
studies
meta-analyses
indicate
that
TCM
provides
significant
benefits,
specific
herbal
compounds
monomers
demonstrating
protective
effects
on
the
mucosa
through
mechanisms
including
anti-inflammation,
anti-oxidation,
cellular
proliferation
apoptosis,
Finally,
it
pointed
out
requires
standardized
research
unified
standards,
constantly
clarifies
improves
evaluation
criteria
each
dimension
function.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 18, 2025
Gastric
cancer
(GC)
is
a
prevalent
malignant
tumor
that
originates
from
the
epithelial
cells
of
gastric
mucosa,
predominantly
in
form
adenocarcinoma.
Extensive
research
has
confirmed
significant
role
autophagy
initiation,
progression,
and
chemoresistance
GC.
The
potential
traditional
Chinese
medicine
(TCM)
to
exert
anti-tumor
effects
by
modulating
been
demonstrated,
particularly
context
GC
prevention
treatment.
Natural
products
(NPs)
have
great
therapeutic
treatment
targeting
autophagy-related
genes
signaling
pathways
intervene
biological
behaviors
such
as
proliferation,
metastasis,
invasion
death.
This
article
describes
molecular
mechanisms
key
markers
autophagy,
involved
GC-associated
(PI3K/AKT/mTOR,
AMPK,
MAPK,
p53),
summarizes
mechanism
Helicobacter
pylori
infection
GC,
how
interacts
with
apoptotic
iron-death
processes
wide-ranging
influences
these
factors
play
process.
Finally,
this
paper
systematically
natural
compounds
terpenoids,
polyphenols,
alkaloids,
saponins,
polysaccharides
modulate
targets
for
evaluates
toxic
NPs,
providing
more
compelling
rationale
direction
therapy.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Март 3, 2023
Background:
Cancer,
also
known
as
a
malignant
tumor,
is
caused
by
the
activation
of
oncogenes,
which
leads
to
uncontrolled
proliferation
cells
that
results
in
swelling.
According
World
Health
Organization
(WHO),
cancer
one
main
causes
death
worldwide.
The
variables
limiting
efficacy
anti-tumor
treatments
are
side
effects
and
drug
resistance.
search
for
natural,
safe,
low
toxicity,
efficient
chemical
compounds
tumor
research
essential.
Berberine
pentacyclic
isoquinoline
quaternary
ammonium
alkaloid
isolated
from
Berberis
Coptis
has
long
been
used
clinical
settings.
Studies
recent
years
have
reported
use
berberine
treatment.
In
this
study,
we
performed
bibliometric
analysis
berberine-
tumor-related
research.
Materials
methods:
Relevant
articles
January
1,
2002,
December
31,
2021,
were
identified
Web
Science
Core
Collection
(WOSCC)
Clarivate
Analytics.
Microsoft
Excel,
CiteSpace,
VOSviewer,
an
online
platform
literary
metrology
analysis.
Results:
A
total
1368
publications
had
unique
characteristics.
Publications
China
most
common
(783
articles),
Y.
B.
Feng
(from
China)
was
productive
author,
with
highest
citations.
Medical
University
(Taiwan)
Sun
Yat-sen
(China)
two
organizations
largest
numbers
(36
each).
Frontiers
Pharmacology
commonly
occurring
journal
(29
articles).
present
body
focused
on
mechanism,
molecular
docking,
oxidative
stress
tumors.
Conclusion:
Research
tumors
thoroughly
reviewed
using
knowledge
map
methods.
study
reveal
dynamic
evolution
provide
basis
strategic
planning