Applied Ecology and Environmental Research,
Год журнала:
2024,
Номер
22(2), С. 1495 - 1508
Опубликована: Янв. 1, 2024
Natural
antioxidant
use
has
increased
as
a
consequence
of
consumer
desire
for
natural
and
organic
foods.Almonds
(Prunus
dulcis
Mill.D.)
are
an
important
food
item
both
nutritionally
medicinally.The
health
advantages
attributed
to
these,
the
value-added
products
developed
from
them
have
been
linked
activities
phenolic
compounds
in
nuts.The
nutritional
characteristics,
total
contents,
activity
almond
with
brown
skin
without
were
examined
current
study.The
findings
facts
support
possibility
using
almonds
sector
they
propose
that
significant
source
energy,
protein,
fiber,
lipid.The
results
content
ranged
240.6±3.2-295.5±4.2
232.3±2.8-278.4±3.6
mg
GAE/100
g.The
inhibition
DPPH
radical
scavenging
capacity
varied
over
37.60-65.09%
28.83-45.51%,without
at
concentration
5
mg/ml.The
reducing
power
(absorbance
700
nm)
increase
all
varieties
however
these
higher
varieties.This
study
showed
excellent
sources
nutrients
antioxidants
potential
value
addition
nutraceutical
development.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
172, С. 116207 - 116207
Опубликована: Янв. 31, 2024
Lung
cancer
ranks
among
the
most
prevalent
forms
of
and
remains
a
significant
factor
in
cancer-related
mortality
across
world.
It
poses
challenges
to
healthcare
systems
society
as
whole
due
its
high
incidence,
rates,
late-stage
diagnosis.
Resveratrol
(RV),
natural
compound
found
various
plants,
has
shown
potential
nanomedicine
for
lung
treatment.
RV
varied
effects
on
cells,
including
promoting
apoptosis
by
increasing
pro-apoptotic
proteins
(Bax
Bak)
decreasing
anti-apoptotic
(Bcl-2).
also
hinders
cell
proliferation
influencing
important
signaling
pathways
(MAPK,
mTOR,
PI3K/Akt,
Wnt/β-catenin)
that
govern
progression.
In
addition,
acts
potent
antioxidant,
diminishing
oxidative
stress
safeguarding
cells
against
DNA
damage.
However,
using
alone
treatment
drawbacks,
such
low
bioavailability,
lack
targeting
ability,
susceptibility
degradation.
contrast,
nanoparticle-based
delivery
address
these
limitations
hold
promise
improving
outcomes
cancer;
nanoparticle
formulations
offer
advantages
improved
drug
delivery,
increased
stability,
controlled
release,
targeted
cells.
This
article
will
provide
an
overview
cancer,
explore
therapeutic
agent,
discuss
benefits
highlight
nanoparticles
treatment,
cancer.
By
optimizing
clinical
application,
future
studies
aim
enhance
overall
improve
prognosis
patients.
Molecules,
Год журнала:
2024,
Номер
29(3), С. 741 - 741
Опубликована: Фев. 5, 2024
Phlorizin,
as
a
flavonoid
from
wide
range
of
sources,
is
gradually
becoming
known
for
its
biological
activity.
Phlorizin
can
exert
antioxidant
effects
by
regulating
the
IL-1β/IKB-α/NF-KB
signaling
pathway.
At
same
time,
it
exerts
antibacterial
activity
reducing
intracellular
DNA
agglutination,
protein
and
energy
synthesis,
destroying
metabolism.
In
addition,
phlorizin
also
has
various
pharmacological
such
antiviral,
antidiabetic,
antitumor,
hepatoprotective
effects.
Based
on
domestic
foreign
research
reports,
this
article
reviews
plant
extraction,
activities
phlorizin,
providing
reference
improving
clinical
application
phlorizin.
Heliyon,
Год журнала:
2024,
Номер
10(11), С. e31957 - e31957
Опубликована: Май 28, 2024
BackgroundLactic
acid
bacteria
(LAB)
are
utilized
as
a
starter
culture
in
the
manufacturing
of
fermented
dairy
items,
preservative
for
various
food
products,
and
probiotic.
In
our
country,
some
research
has
been
carried
out,
even
if
LAB
plays
principal
role
preservation
improves
texture
taste
foods,
that
is
why
we
tried
to
evaluate
their
probiotic
effect.
The
objective
this
was
determine
antibacterial
activity
Lactococcus
lactis
(L.
lactis)
against
Staphylococcus
aureus
(S.
aureus)
ATCC
29213,
investigate
antioxidant
activity,
characterize
sensitivity
18
antibiotics.MethodsA
total
23
subsp.
cremoris,
L.
Lactis
diacetylactis,
were
isolated
from
cow's
raw
milk.
performed
using
two
techniques,
competition
nutrients
technique
utilizing
components
nature,
disk
diffusion
method.
studied
different
antibiotics
tested
on
Man
rogosa
sharp
(MRS)
agar
commercial
antibiotic
disks.
All
strains
examined
activity.
by
2,2-diphenyl-1
picrylhydrazyl
(DPPH).ResultsThe
results
showed
MRS
medium
more
adapted
than
Muller
Hinton
Agar
(MHA)
S.
29213.
Also,
exhibited
notable
degree
displayed
higher
activities,
followed
ssp.
biovar.
lastly,
cremoris
Lc
26
among
all
high
potential
reaching
40±3
mm
slightly
moderate
(10.56±1.28%-26.29±0.05%).
resistance
test
indicate
resistant
cefotaxime,
sulfamethoxazole-trimethoprim,
streptomycin
sensitive
Ampicillin,
Amoxicillin,
Penicillin
G,
Teicoplanin,
Vancomycin,
Gentamicin
500,
Tetracycline,
Chloramphenicol.
These
strain
falls
within
criteria
not
posing
any
harmful
effects
human
health.
important
properties
recorded
derived
production
active
metabolites,
such
protein,
diacetyl,
hydrogen
peroxide,
lactic
acid,
together
with
fight
nutrients.ConclusionThis
study
suggests
could
be
added
an
agent
29213
can
provide
nutritional
property
potential.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Март 25, 2024
Abstract
Endophytic
fungi
are
microorganisms
that
considered
as
a
potential
source
of
natural
compounds,
and
can
be
applied
in
various
industries.
The
aims
this
research
were
molecular
identification
endophytic
isolated
from
the
Gundelia
tournefortii
stems,
investigation
their
biological
activities
well
phenolic
fatty
acid
profile.
Surface
sterilized
stems
G.
placed
on
potato
dextrose
agar
(PDA)
to
isolate
fungal
endophytes.
Genomic
DNA
was
extracted
by
CTAB
method,
PCR
amplification
performed
ITS
1
4
primers.
enzyme
production
determined
based
formation
clear
zone
appeared
around
colonies
fungus.
anti-oxidant
activity
evaluated
measuring
amount
free
radicals
DPPH.
Also,
total
phenol
flavonoid
contents
measured
obtained
Folin-Ciocalteu
aluminum
chloride
colorimetric
methods,
respectively.
Moreover,
separation
acids
done
HPLC
GC,
Phylogenetic
analysis
Internal
Transcribed
Spacer
(ITS)
region,
five
isolates
identified
following:
Aspergillus
niger
,
Penicillium
glabrum
Alternaria
alternata
A.
tenuissima
Mucor
circinelloides
.
Evaluation
enzymatic
properties
showed
P.
gabrum
(31
±
1.9
mm),
(23
1.7)
had
more
ability
for
producing
pectinase
cellulase.
extract
(IC
50
=
471
29
µg/mL)
highest
properties,
followed
512
19
µg/mL).
greatest
phenols
flavonoids
(8.2
0.4
mg
GAL/g
2.3
0.3
QE/g,
respectively).
quantification
rosmarinic
acid,
para-coumaric
meta-coumaric
(42.02
1.31,
7.53
0.19,
5.41
0.21
mg/g,
respectively)
main
studied
fungi.
confirmed
that,
all
fungi,
stearic
(27.9–35.2%),
oleic
(11.3–17.3%),
palmitic
(16.9–23.2%),
linoleic
(5.8–11.6%),
caprylic
(6.3–10.9%).
Our
finding
bioactive
which
could
used
This
is
first
report
associated
with
provides
knowledge
future
use
biotechnological
processes.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 30, 2024
Abstract
The
intersection
of
nanotechnology
and
pharmacology
has
revolutionized
the
delivery
efficacy
chemotherapeutic
agents,
notably
docetaxel,
a
key
drug
in
cancer
treatment.
Traditionally
limited
by
poor
solubility
significant
side
effects,
docetaxel’s
therapeutic
potential
been
significantly
enhanced
through
its
incorporation
into
nanoplatforms,
such
as
nanofibers
nanoparticles.
This
advancement
offers
targeted
delivery,
controlled
release,
improved
bioavailability,
dramatically
reducing
systemic
toxicity
enhancing
patient
outcomes.
Nanofibers
provide
versatile
scaffold
for
release
utilizing
techniques
like
electrospinning
to
tailor
profiles.
Nanoparticles,
on
other
hand,
enable
precise
tumor
cells,
minimizing
damage
healthy
tissues
sophisticated
encapsulation
methods
nanoprecipitation
emulsion.
These
nanotechnologies
not
only
improve
pharmacokinetic
properties
docetaxel
but
also
open
new
avenues
regenerative
medicine
facilitating
therapy
cellular
regeneration.
narrative
review
highlights
transformative
impact
docetaxel-loaded
nanoplatforms
oncology
beyond,
showcasing
overcome
limitations
traditional
chemotherapy
pave
way
future
innovations
therapies.
Through
these
advancements,
promises
era
precision
medicine,
treatments
while
adverse
effects.
Graphical
Alexandria Engineering Journal,
Год журнала:
2024,
Номер
93, С. 80 - 89
Опубликована: Март 14, 2024
The
purpose
of
this
work
was
to
construct
an
electrochemical
sensor
for
the
detection
imatinib.
It
based
on
a
modified
glassy
carbon
electrode
(chitosan/rGO/GCE)
that
reduced
graphene
oxide
nanocomposite.
By
employing
straightforward
drop-casting
technique,
rGO/chitosan
composite
applied
GCE
surface.
XRD,
FT-IR,
and
FE-SEM
structural
studies
verified
successfully
nanocomposite
formed.
synergistic
effect
rGO
chitosan
boosted
electron
transfer
kinetics
facilitated
oxidation
reaction
imatinib
surface,
according
experiments,
which
indicated
chitosan/rGO/GCE's
sensitive,
selective,
stable
response
findings
showed
sensitivity
0.16502
μA/μM,
limit
value
7.3
nM,
wide
linear
range
1–300
µM.
Differential
pulse
voltammetry
measurements
were
performed
prepared
human
serum
urine
samples
evaluate
applicability
chitosan/rGO/GCE
in
real
samples.
For
genuine
samples,
good
recoveries
ranging
from
95.00%
99.20%
with
relative
standard
deviation
3.10–4.49%.
These
variety
may
be
accurately
analyzed
using
chitosan/rGO/GCE.
