Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Abstract
Doxorubicin
(DOX)
is
a
highly
potent
broad-spectrum
anticancer
drug,
but
it
has
severe
side
effects,
including
hepatotoxicity.
Therefore,
we
evaluated
the
efficacy
of
febuxostat
(FBX),
specific
inhibitor
xanthine
oxidase
and
antioxidant,
in
blocking
hepatotoxicity
associated
with
DOX
rats.
Rats
were
treated
FBX
(10
or
15
mg/kg/day
orally
for
2
weeks)
given
(15
mg/kg
as
single
dose
at
7th
day,
intraperitoneal)
to
induce
The
results
indicated
that
could
reduce
pathological
alterations
liver
tissues
induced
by
ameliorate
inappropriate
changes
function
biomarkers
(AST,
ALT,
ALP)
serum,
oxidative
stress
parameters
(catalase,
superoxide
dismutase,
NOX1,
NQO-1,
HO-1,
Keap-1,
Nrf2)
inflammatory
markers
(NF-κB
p65,
TNF-α,
NLRP3).
Additionally,
attenuated
p53,
BAX,
cytochrome
C,
caspase-9,
caspase-3
levels
restrain
cell
apoptosis.
In
addition,
therapy
was
found
increase
protein
SIRT-1
AMPK
liver.
These
findings
demonstrate
can
caused
rats
through
mechanisms
counteract
stress,
inflammation,
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Март 7, 2025
It
is
well
acknowledged
that
metabolic
disorder
binds
closely
with
preeclampsia,
though
some
of
the
causal
relationships
are
still
ambiguous.
This
review
systematically
summarizes
characteristics
carbohydrates,
lipids,
amino
acids,
and
glycans
in
highlighting
their
roles
oxidative
stress,
trophoblast
autophagy,
inflammatory
response,
vascular
tone
regulation.
Key
findings
include
upregulated
glycolysis
impaired
mitochondrial
function
contributing
to
ATP
deficiency,
dysregulated
lipid
metabolism
exacerbating
stress
dysfunction,
acid
imbalances
disrupting
immune
responses
redox
homeostasis.
Emerging
therapies,
such
as
metformin
pravastatin,
demonstrate
potential
targeting
these
pathways
for
prevention
treatment.
Here,
we
reviewed
thoroughly
related
literature
a
view
delineating
association
nutrient
so
could
explore
promising
therapeutic
approach.
Journal of Cancer,
Год журнала:
2024,
Номер
15(13), С. 4097 - 4112
Опубликована: Янв. 1, 2024
Ferroptosis
has
been
characterized
as
non-apoptotic
programmed
cell
death
and
is
considered
a
novel
strategy
for
antitumor
treatment.
The
factor
that
binds
to
inducer
of
short
transcripts-1
(FBI-1)
an
important
proto-oncogene
playing
multiple
roles
in
human
malignancies
the
development
resistance
therapy.
However,
FBI-1
ferroptosis
endocrine
independent
prostate
carcinoma
are
still
unknown.
results
this
study
showed
inhibited
PC-3
cells
(a
typical
endocrine-independent
line)
via
miR-324-3p/glutathione
peroxidase
4
(miR-324-3p/GPX4)
axis.
Overexpression
enhanced
expression
levels
GPX4.
In
contrast,
knockdown
decreased
GPX4
induced
cells.
miR-324-3p
by
targeting
3'-untranslated
region
induce
ferroptosis.
Notably,
increased
repressing
miR-324-3p.
transcription
was
mediated
specificity
protein
1
(SP1),
repressed
activation
SP1.
clinical
specimens,
endogenous
were
positively
associated
with
Glutathione
Peroxidase
(GPX4)
negatively
related
Therefore,
indicated
miR-324-3p/GPX4
axis
participates
FBI-1-mediated
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(16), С. 12626 - 12626
Опубликована: Авг. 10, 2023
Non-small
cell
lung
cancer
(NSCLC)
is
a
common
clinical
malignant
tumor
with
limited
therapeutic
drugs.
Leading
by
cytotoxicity
against
NSCLC
lines
(A549
and
PC9),
bioactivity-guided
isolation
of
components
from
Peganum
harmala
seeds
led
to
the
pegaharoline
A
(PA).
PA
was
elucidated
as
structurally
novel
aniline
derivative,
originating
tryptamine
pyrrole
ring
cleaved
degradation
carbon.
Biological
studies
showed
that
significantly
inhibited
proliferation,
suppressed
DNA
synthesis,
arrested
cycle,
colony
formation
HUVEC
angiogenesis,
blocked
invasion
migration.
Molecular
docking
surface
plasmon
resonance
(SPR)
demonstrated
could
bind
CD133,
correspondingly
decreased
CD133
expression
activate
autophagy
via
inhibiting
PI3K/AKT/mTOR
pathway,
increased
ROS
levels,
Bax,
caspase-3
promote
apoptosis.
also
decrease
p-cyclinD1
p-Erk1/2
block
EMT
pathway
inhibit
growth,
invasion,
According
these
results,
growth
blocking
pathways.
This
study
provides
evidence
has
promising
future
candidate
for
developing
drugs
treating
NSCLC.
Microscopy Research and Technique,
Год журнала:
2024,
Номер
87(7), С. 1598 - 1614
Опубликована: Март 5, 2024
Abstract
Cardiotoxicity
induced
by
doxorubicin
(Dox)
is
a
major
complication
in
cancer
patients.
Exosomes
(Ex)
derived
from
mesenchymal
cells
could
be
promising
therapeutic
for
various
heart
diseases.
This
study
investigated
the
role
of
Ex
Dox‐induced
cardiotoxicity
and
its
mechanistic
insights,
using
Sacubitril/valsartan
(S/V)
as
reference
drug
widely
recommended
failure
management.
The
involved
24
Wistar
rats,
divided
into
control,
Dox,
Dox
+
S/V,
groups.
rats
were
assessed
cardiac
enzymes,
inflammatory
oxidative
stress
markers.
Immunohistochemical
expression
caspase‐1,
nuclear
factor
erythroid
2‐related
2
(NrF2),
E‐Cadherin,
CD117/c‐kit,
Platelet‐derived
growth
factor‐α
(PDGFα)
was
evaluated.
P53
Annexin
V
PCR.
Histological
examination
performed
hematoxylin
eosin
Sirius
red
stains.
ameliorated
adverse
pathological
changes
significantly
decreased
enzymes
also
exerted
antifibrotic
antiapoptotic
effect
tissue.
treatment
improved
NrF2
immunohistochemistry,
up‐regulated
E‐Cadherin
immune
expression,
restored
telocyte
markers
CD117/c‐kit
PDGFα.
can
mitigate
acting
an
anti‐inflammatory,
antioxidant,
antiapoptotic,
agents,
restoring
telocytes
modulating
epithelial
transition.
Research
Highlights
exhibit
positive
CD90
CD105
whereas
showing
−ve
CD
34
flow
cytometry.
restore
immunohistochemical
alleviate
myocardial
apoptosis,
fibrosis.
European Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
200, С. 106849 - 106849
Опубликована: Июль 9, 2024
Doxorubicin
(DOX)
is
an
anthracycline
chemotherapy
drug
widely
employed
in
the
treatment
of
various
cancers,
known
for
its
potent
antineoplastic
properties
but
often
associated
with
dose-dependent
cardiotoxicity,
limiting
clinical
use.
This
review
explores
complex
molecular
details
that
determine
heart-protective
effectiveness
carvedilol
relation
to
cardiotoxicity
caused
by
DOX.
The
harmful
effects
DOX
on
heart
cells
could
include
oxidative
stress,
DNA
damage,
iron
imbalance,
disruption
autophagy,
calcium
apoptosis,
dysregulation
topoisomerase
2-beta,
arrhythmogenicity,
and
inflammatory
responses.
carefully
reveals
how
serves
as
a
strong
protective
mechanism,
strategically
reducing
each
aspect
cardiac
damage
Carvedilol's
antioxidant
capabilities
involve
neutralizing
free
radicals
adjusting
crucial
enzymes.
It
skillfully
manages
balance,
controls
restores
balance
essential
cellular
stability.
Moreover,
anti-apoptotic
are
outlined
through
adjustment
Bcl-2
family
proteins
activation
Akt
signaling
pathway.
medication
also
2-beta
reduces
renin-angiotensin-aldosterone
system,
together
offering
thorough
defense
against
induced
These
findings
not
only
provide
detailed
understanding
into
mechanisms
coordinate
protection
offer
considerable
potential
creation
targeted
strategies
intended
relieve
chemotherapy.
