Understanding the mechanisms of disease modifying effects of aerobic exercise in people with Alzheimer’s disease

Ageing Research Reviews, Год журнала: 2024, Номер 94, С. 102202 - 102202

Опубликована: Янв. 23, 2024

Язык: Английский

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Friend or foe: Lactate in neurodegenerative diseases

Ageing Research Reviews, Год журнала: 2024, Номер 101, С. 102452 - 102452

Опубликована: Авг. 8, 2024

Язык: Английский

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Lactate Protects Microglia and Neurons from Oxygen–Glucose Deprivation/Reoxygenation

Neurochemical Research, Год журнала: 2024, Номер 49(7), С. 1762 - 1781

Опубликована: Март 29, 2024

Язык: Английский

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Physical exercise regulates microglia in health and disease

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Июнь 7, 2024

There is a well-established link between physical activity and brain health. As such, the effectiveness of exercise as therapeutic strategy has been explored in variety neurological contexts. To determine extent to which could be most beneficial under different circumstances, studies are needed uncover underlying mechanisms behind benefits activity. Interest grown understanding how can regulate microglia, resident immune cells central nervous system. Microglia key mediators neuroinflammatory processes play role maintaining homeostasis healthy pathological settings. Here, we explore evidence suggesting that potential microglia various animal models. We emphasize areas where future research contribute uncovering engaging exercise.

Язык: Английский

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High-intensity interval training and medium-intensity continuous training may affect cognitive function through regulation of intestinal microbial composition and its metabolite LPS by the gut-brain axis

Life Sciences, Год журнала: 2024, Номер 352, С. 122871 - 122871

Опубликована: Июнь 25, 2024

Язык: Английский

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Impact of Diet and Exercise on Mitochondrial Quality and Mitophagy in Alzheimer's disease

Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102734 - 102734

Опубликована: Март 1, 2025

Язык: Английский

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Treadmill Exercise Modulates the Leptin/LepR/GSK-3β Signalling Pathway to Improve Leptin Sensitivity and Alleviate Neuroinflammation in High-Fat Diet-Fed APP/PS1 Mice

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

Язык: Английский

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Mapping the scientific research on exercise therapy for Alzheimer’s disease: a scientometric study of hotspots and emerging trends

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17

Опубликована: Апрель 3, 2025

Background Alzheimer’s disease (AD) is the most common form of dementia globally, placing a substantial economic burden on patients and society. Exercise serves as an adjuvant therapy for AD with low incidence related adverse events. As non-pharmacological intervention, it has demonstrated significant potential in AD. Objective This study examines key hotspots emerging trends exercise AD, offering valuable insights researchers engaged future research this field. Methods The Web Science Core Collection database was utilized to search literature from January 1, 2000, November 2024, 1,372 relevant articles being identified. And CiteSpace 6.2.R4 VOSviewer were used evaluate bibliometric indicators. Results Since number publications field been increasing. In addition well-known areas research, such impact cognitive function, combination medication therapy, effects specific symptoms, music may also focus more novel topics. These include integration design implementation interventions, dendritic spines, neurophysiological mechanisms. Furthermore, analysis keywords reveals that current main direction exploring physiological mechanisms through which affects includes three trends: impairment patients, brain-derived neurotrophic factor (BDNF) Amyloid beta, influence Stress neuroinflammation. Conclusion results indicate interventions using alleviate negative symptoms well combining are gaining increasing attention researchers. Meanwhile, topics should attract scholarly interest. Additionally, behind could be research.

Язык: Английский

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Effects of home-based and telerehabilitation exercise on mental and physical health, and disease cost in people with Alzheimer’s disease: A meta-analysis

Ageing Research Reviews, Год журнала: 2024, Номер 97, С. 102284 - 102284

Опубликована: Апрель 9, 2024

Язык: Английский

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Voluntary wheel exercise improves learning and memory impairment caused by hippocampal Hb-α deficiency by reducing microglial activation and reversing synaptic damage

Brain Behavior and Immunity, Год журнала: 2025, Номер 127, С. 81 - 95

Опубликована: Март 7, 2025

Язык: Английский

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