Circadian
clocks
may
mediate
lifespan
extension
by
caloric
or
dietary
restriction
(DR).
We
find
that
the
core
clock
transcription
factor
Clock
is
crucial
for
a
robust
longevity
and
fecundity
response
to
DR
in
Drosophila
.
To
identify
clock-controlled
mediators,
we
performed
RNA-sequencing
from
abdominal
fat
bodies
across
24
h
day
after
just
5
days
under
control
diets.
In
contrast
more
chronic
regimens,
did
not
detect
significant
changes
rhythmic
expression
of
genes.
Yet
discovered
induced
de
novo
rhythmicity
increased
output
Network
analysis
revealed
network
connectivity
one
module
comprised
genes
encoding
proteasome
subunits.
Adult,
body
specific
RNAi
knockdown
demonstrated
subunits
contribute
DR-mediated
extension.
Thus,
links
Ageing Research Reviews,
Год журнала:
2024,
Номер
96, С. 102278 - 102278
Опубликована: Март 19, 2024
Vascular
dementia
(VaD)
is
the
second
most
common
type
of
dementia.
VaD
synonymous
with
ageing,
and
its
symptoms
place
a
significant
burden
on
health
wellbeing
older
people.
Despite
identification
substantial
number
risk
factors
for
VaD,
pathological
mechanisms
underpinning
this
disease
remain
to
be
fully
elucidated.
Consequently,
biogerontological
imperative
exists
highlight
modifiable
lifestyle
which
can
mitigate
against
developing
VaD.
This
review
will
critically
examine
some
have
been
revealed
modulate
risk.
The
survey
commences
by
providing
an
overview
putative
are
associated
pathobiology
Next,
influence
examined.
Finally,
emerging
treatment
avenues
including
epigenetics,
gut
microbiome,
pro-longevity
pharmaceuticals
discussed.
By
drawing
key
evidence
together,
it
our
hope
that
used
inform
future
experimental
investigations
in
field.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(14), С. 11538 - 11538
Опубликована: Июль 16, 2023
Ageing
constitutes
the
biggest
risk
factor
for
poor
health
and
adversely
affects
integrity
function
of
all
cells,
tissues,
organs
in
human
body.
Vascular
ageing,
characterised
by
vascular
stiffness,
endothelial
dysfunction,
increased
oxidative
stress,
chronic
low-grade
inflammation,
early-stage
atherosclerosis,
may
trigger
or
exacerbate
development
age-related
diseases,
which
each
year
contribute
to
more
than
3.8
million
deaths
Europe
alone
necessitate
a
better
understanding
mechanisms
involved.
To
this
end,
large
number
recent
preclinical
clinical
studies
have
focused
on
exponential
accumulation
senescent
cells
system
paid
particular
attention
specific
roles
senescence-associated
secretory
phenotype,
proteostasis
age-mediated
modulation
certain
microRNA
(miRNAs),
contribution
other
major
factors,
notably
diabetes,
hypertension,
smoking,
ageing
elderly.
The
data
generated
paved
way
various
senotherapeutic
interventions,
ranging
from
application
synthetic
natural
senolytics
senomorphics
attempt
modify
lifestyle,
control
diet,
restrict
calorie
intake.
However,
guidelines,
considering
severity
characteristics
need
be
established
before
widespread
use
these
agents.
This
review
briefly
discusses
molecular
cellular
summarises
efficacy
widely
studied
senotherapeutics
context
ageing.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Апрель 9, 2024
Limited
resources
affect
an
organism's
physiology
through
the
conserved
metabolic
pathway,
mechanistic
target
of
rapamycin
(mTOR).
Males
and
females
often
react
differently
to
nutritional
limitation,
but
whether
it
leads
differential
mTOR
pathway
expression
remains
unknown.
Recently,
we
found
that
dietary
restriction
(DR)
induced
significant
changes
in
genes
female
Japanese
quails
(Coturnix
japonica).
We
simultaneously
exposed
32
male
either
20%,
30%,
40%
or
ad
libitum
feeding
for
14
days
determined
six
key
liver
investigate
sex
differences
patterns.
DR
significantly
reduced
body
mass,
albeit
effect
was
milder
males
compared
females.
observed
sex-specific
gene
expression.
downregulated
more
than
males.
Under
moderate
DR,
ATG9A
RPS6K1
expressions
were
increased
Like
females,
mass
correlated
positively
with
IGF1,
negatively
RS6K1
expressions.
Our
findings
highlight
sexes
may
cope
deficits
emphasise
importance
considering
sexual
studies
restriction.
Journal of Experimental Biology,
Год журнала:
2025,
Номер
228(2)
Опубликована: Янв. 15, 2025
ABSTRACT
The
ability
of
organisms
to
cope
with
poor
quality
nutrition
is
essential
for
their
persistence.
For
species
a
short
generation
time,
the
nutritional
environments
can
transcend
generations,
making
it
beneficial
adults
prime
offspring
particular
diets.
However,
our
understanding
adaptive
generational
responses,
including
those
diet
quality,
are
still
very
limited.
Here,
we
used
vinegar
fly,
Drosophila
melanogaster,
investigate
whether
females
developing
as
larvae
on
nutritionally
produce
that
primed
nutrient
deficiencies
in
following
generations.
We
found
developed
low-quality
diets
produced
that,
similarly
diets,
had
both
increased
egg-to-adult
viability
and
starvation
tolerance
compared
experiencing
nutrient-rich
diet.
When
testing
persistence
such
priming,
just
one
high-quality
sufficient
erase
signal
priming.
A
global
transcriptomic
profile
analysis
male
suggests
observed
phenotypic
priming
not
constitutive
adjustment
adults;
instead,
probably
larvae,
enabling
them
initiate
an
response
when
exposed
Our
results
support
important
mechanism
enables
transient
fluctuations.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 12, 2025
This
study
investigates
the
association
between
dietary
methyl
donor
nutrients
intake
and
phenotypic
aging.
cross-sectional
comprised
27,211
adult
participants
from
NHANES
2005-2018.
The
methyl-donor
nutritional
quality
index
(MNQI)
was
calculated
by
assessing
of
seven
nutrients:
protein,
folate,
choline,
riboflavin,
vitamin
B6,
B12,
zinc.
Phenotypic
age
acceleration
(PhenoAge.Accel)
using
biochemical
markers
to
assess
biological
Weighted
generalized
linear
regression
models
were
utilized
associations
MNQI
PhenoAge.Accel,
impact
different
demographic
health
characteristics
evaluated
through
interaction
effect
tests.
After
adjusting
for
various
potential
confounding
factors,
a
significant
negative
found
PhenoAge.Accel
(β
=
-
0.66;
95%
CI
0.91,
0.40;
P
<
0.0001),
indicating
that
an
increase
in
is
associated
with
slowdown
PhenoAge.Accel.
Furthermore,
subgroup
analysis
indicated
stronger
negatively
males
0.94;
1.36,
0.52)
interactions
(Pinteraction
0.02).
In
populations,
PhenoAge
Accel,
suggesting
choosing
high-quality
foods
can
help
develop
effective
strategies
enhance
healthy
longevity.
Experimental Gerontology,
Год журнала:
2023,
Номер
179, С. 112256 - 112256
Опубликована: Июль 17, 2023
In
the
last
decade
epigenetics
has
come
to
fore
as
a
discipline
which
is
central
biogerontology.
Age
associated
epigenetic
changes
are
routinely
linked
with
pathologies,
including
cardiovascular
disease,
cancer,
and
Alzheimer's
disease;
moreover,
clocks
capable
of
correlating
biological
age
chronological
in
many
species
humans.
Recent
intriguing
empirical
observations
also
suggest
that
inherited
effects
could
influence
lifespan/longevity
variety
organisms.
If
this
case,
an
imperative
exists
reconcile
processes
evolution
ageing.
This
review
will
critically
evaluate
from
evolutionary
perspective.
The
overarching
aim
integrate
evidence
suggests
inheritance
modulates
main
theories
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Янв. 4, 2023
Abstract
Circadian
clocks
may
mediate
lifespan
extension
by
caloric
or
dietary
restriction
(DR).
We
find
that
the
core
clock
transcription
factor
Clock
is
crucial
for
a
robust
longevity
and
fecundity
response
to
DR
in
Drosophila
.
To
identify
clock-controlled
mediators,
we
performed
RNA-sequencing
from
abdominal
fat
bodies
across
24
h
day
after
just
5
days
under
control
diets.
In
contrast
more
chronic
regimens,
did
not
detect
significant
changes
rhythmic
expression
of
genes.
Yet
discovered
induced
de
novo
rhythmicity
increased
output
Network
analysis
revealed
network
connectivity
one
module
comprised
genes
encoding
proteasome
subunits.
Adult,
body
specific
RNAi
knockdown
demonstrated
subunits
contribute
DR-mediated
extension.
Thus,
links
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 11, 2024
Abstract
Limited
resources
affect
an
organism’s
physiology
through
the
conserved
metabolic
pathway,
mechanistic
target
of
rapamycin
(mTOR).
Males
and
females
often
react
differently
to
nutritional
limitation,
but
whether
it
leads
differential
mTOR
pathway
expression
remains
unknown.
Recently,
we
found
that
dietary
restriction
(DR)
induced
significant
changes
in
genes
female
Japanese
quails
(
Coturnix
japonica
).
We
simultaneously
exposed
32
male
either
20%,
30%,
40%
or
ad
libitum
feeding
for
14
days
determined
six
key
liver
investigate
sex
differences
patterns.
DR
significantly
reduced
body
mass,
albeit
effect
was
milder
males
compared
females.
observed
sex-specific
gene
expression.
downregulated
more
than
males.
Under
moderate
DR,
ATG9A
RPS6K1
were
increased
Like
females,
mass
correlated
positively
with
IGF1,
negatively
RS6K1
.
Our
findings
highlight
sexes
may
cope
deficits
emphasise
importance
considering
sexual
studies
restriction.
Circadian
clocks
may
mediate
lifespan
extension
by
caloric
or
dietary
restriction
(DR).
We
find
that
the
core
clock
transcription
factor
Clock
is
crucial
for
a
robust
longevity
and
fecundity
response
to
DR
in
Drosophila
.
To
identify
clock-controlled
mediators,
we
performed
RNA-sequencing
from
abdominal
fat
bodies
across
24
h
day
after
just
5
days
under
control
diets.
In
contrast
more
chronic
regimens,
did
not
detect
significant
changes
rhythmic
expression
of
genes.
Yet
discovered
induced
de
novo
rhythmicity
increased
output
Network
analysis
revealed
network
connectivity
one
module
comprised
genes
encoding
proteasome
subunits.
Adult,
body
specific
RNAi
knockdown
demonstrated
subunits
contribute
DR-mediated
extension.
Thus,
links
