Inorganic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
Photothermal
therapy
is
a
promising
strategy
for
treating
tumors
and
bacterial
infections
by
using
light
irradiation
to
locally
heat
tissues.
Metalloisoporphyrinoid
materials
have
been
investigated
their
use
as
singlet
oxygen
photosensitizers
photodynamic
but
remain
underexplored
photothermal
agents.
Recently,
two
metallophlorin
metalloisocorrole
were
found
strong
near-infrared
absorbance,
with
low
photoluminescent
quantum
yields,
suggesting
high
rates
of
nonradiative
decay.
Here
we
demonstrate
that
when
encapsulated
into
aggregated
organic
nanoparticles
(a-Odots),
these
show
conversion
efficiencies
between
67.3
±
8.4
75.7
4.1%.
When
considered
alongside
ability
generate
oxygen,
may
promise
agents
dual
therapy.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(5), С. 2660 - 2676
Опубликована: Май 9, 2024
Wound
healing,
particularly
for
chronic
wounds,
presents
a
considerable
difficulty
due
to
differences
in
biochemical
and
cellular
processes
that
occur
different
types
of
wounds.
Recent
technological
breakthroughs
have
notably
advanced
the
understanding
diagnostic
therapeutic
approaches
wound
healing.
The
evolution
care
has
seen
transition
from
traditional
textile
dressings
variety
alternatives,
including
self-healing
hydrogels,
hydrofibers,
foams,
hydrocolloids,
environment
responsive
dressings,
growth
factor-based
therapy,
bioengineered
skin
substitutes,
stem
cell
gene
therapy.
Technological
advancements,
such
as
3D
printing
electronic
(e-skin)
contribute
customization
Despite
these
effectively
managing
wounds
remains
challenging.
This
necessitates
development
treatments
consider
performance,
risk–benefit
balance,
cost-effectiveness.
review
discusses
innovative
strategies
healing
Incorporating
biomarkers
into
coupled
with
corresponding
biosensors
drug
delivery
formulations,
enables
theranostic
approach
treatment
Furthermore,
integrating
power
sources
user
interfaces
like
near-field
communication,
radio
frequency
identification,
Bluetooth
enhances
real-time
monitoring
on-demand
delivery.
It
also
provides
thorough
evaluation
advantages,
patient
compliance,
costs,
durability
emphasizing
smart
formulations
their
preparation
methods.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(3), С. 1756 - 1767
Опубликована: Янв. 12, 2024
Antimicrobial
packing
showed
great
potential
in
extending
the
shelf
life
of
food.
However,
developing
a
new
biocomposite
film
with
an
intelligent
and
efficient
antimicrobial
performance
is
still
desirable.
Herein,
Fe-MoOx
encapsulated
curcumin
(Cur)
filled
chitosan-based
composite
(CCF
films)
was
prepared
by
solvent
casting
method.
The
total
color
differences
CCF
films
were
less
than
30%,
satisfactory
surface
color,
transparency,
hydrophobicity,
thermal
stability
also
obtained.
Besides,
UV-light/water/oxygen
barrier
capability
mechanical
properties
enhanced
incorporation
Cur@Fe-MoOx.
Moreover,
photothermal
thermal-controlled
release
ability,
which
endowed
CCF0.15
excellent
antibacterial
toward
E.
coli
(≥99.95%)
S.
aureus
(≥99.96%)
due
to
synergistic
effect.
exhibited
high
cell
viability
5%
hemolysis
even
under
concentration
500
μg
mL–1.
Based
on
those
unique
characteristics,
chosen
for
tangerine
preservation.
could
prolong
at
least
9
days
compared
unpacking
group,
tangerines
maintain
freshness
characteristics
over
24
day
storage
period.
Such
thermal-mediated
proposed
our
work
promising
food
packaging.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 29, 2024
Abstract
The
challenge
in
treating
diabetic
foot
infections
caused
by
drug‐resistant
bacteria
is
rapidly
eradicating
and
accelerating
wound
healing.
NIR‐II‐induced
photothermal
therapy
(PTT)
offers
notable
advantages
over
conventional
treatments,
such
as
broad‐spectrum
bactericidal
efficacy,
better
penetration
depth
biological
tissues,
higher
skin
tolerance
thresholds,
making
it
particularly
suitable
for
addressing
infections.
Herein,
found
that
NIR‐II
dye
IR26
exhibited
good
effects
but
poor
stability.
By
modifying
with
methoxy
triphenylamine
groups,
a
novel
D–A–D‐type
small
molecule
agent
(IRC)
developed,
high
stability
conversion
efficiency
(44.3%).
IRC
maximum
absorption
wavelength
of
1166
nm
emission
1238
nm.
However,
PTT
alone
cannot
effectively
promote
Therefore,
nanoplatforms
(Cur‐IRC@PCM)
are
developed
coloading
curcumin,
natural
wound–healing
compound,
into
thermosensitive
liposomes
to
treat
MRSA‐infected
wounds.
Under
980
laser
irradiation,
Cur‐IRC@PCM
provided
controlled
the
precise
release
synergizing
eradicate
accelerate
closure.
intelligent
antibacterial
also
exhibits
excellent
biocompatibility,
rendering
promising
therapeutic
tool
biomedical
fields
combating
bacterial
Mild-heat
photothermal
antibacterial
therapy
avoids
heat-induced
damage
to
normal
tissues
but
causes
bacterial
tolerance.
The
use
of
in
synergy
with
chemodynamic
is
expected
address
this
issue.
Herein,
two
pseudo-conjugated
polymers
P
ACS Omega,
Год журнала:
2024,
Номер
9(26), С. 27853 - 27871
Опубликована: Июнь 17, 2024
Chronic
wounds
containing
opportunistic
bacterial
pathogens
are
a
growing
problem,
as
they
the
primary
cause
of
morbidity
and
mortality
in
developing
developed
nations.
Bacteria
can
adhere
to
almost
every
surface,
forming
architecturally
complex
communities
called
biofilms
that
tolerant
an
individual's
immune
response
traditional
treatments.
Wound
dressings
source
potential
treatment
avenue
for
biofilm
infections,
research
has
recently
focused
on
using
nanoparticles
with
antimicrobial
activity
infection
control.
This
Review
categorizes
nanoparticle-based
approaches
into
four
main
types,
each
leveraging
unique
mechanisms
against
biofilms.
Metallic
nanoparticles,
such
silver
copper,
show
promising
data
due
their
ability
disrupt
cell
membranes
induce
oxidative
stress,
although
effectiveness
vary
based
particle
size
composition.
Phototherapy-based
utilizing
either
photodynamic
or
photothermal
therapy,
offer
targeted
microbial
destruction
by
generating
reactive
oxygen
species
localized
heat,
respectively.
However,
efficacy
depends
presence
light
oxygen,
potentially
limiting
use
deeper
more
shielded
Nanoparticles
designed
extracellular
polymeric
substances
directly
target
structure,
enhancing
penetration
agents.
Lastly,
dispersion
represent
novel
strategy,
aiming
weaken
biofilm's
defense
restore
susceptibility
antimicrobials.
While
method
its
advantages,
selection
appropriate
specific
requirements
wound
environment
type
involved.
The
integration
these
not
only
promises
enhanced
outcomes
but
also
offers
reduction
overall
antibiotics,
aligning
urgent
need
innovative
solutions
fight
antibiotic-tolerant
infections.
overarching
objective
employing
diverse
nanoparticle
strategies
is
replace
antibiotics
substantially
reduce
required
dosages,
providing
avenues
management.
