Inorganic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
Photothermal
therapy
is
a
promising
strategy
for
treating
tumors
and
bacterial
infections
by
using
light
irradiation
to
locally
heat
tissues.
Metalloisoporphyrinoid
materials
have
been
investigated
their
use
as
singlet
oxygen
photosensitizers
photodynamic
but
remain
underexplored
photothermal
agents.
Recently,
two
metallophlorin
metalloisocorrole
were
found
strong
near-infrared
absorbance,
with
low
photoluminescent
quantum
yields,
suggesting
high
rates
of
nonradiative
decay.
Here
we
demonstrate
that
when
encapsulated
into
aggregated
organic
nanoparticles
(a-Odots),
these
show
conversion
efficiencies
between
67.3
±
8.4
75.7
4.1%.
When
considered
alongside
ability
generate
oxygen,
may
promise
agents
dual
therapy.
Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101113 - 101113
Опубликована: Июнь 1, 2024
Burns
represent
a
prevalent
global
health
concern
and
are
particularly
susceptible
to
bacterial
infections.
Severe
infections
may
lead
serious
complications,
posing
life-threatening
risk.
Near-infrared
(NIR)-assisted
photothermal
antibacterial
combined
with
antioxidant
hydrogel
has
shown
significant
potential
in
the
healing
of
infected
wounds.
However,
existing
agents
typically
metal-based,
complicated
synthesize,
or
pose
biosafety
hazards.
In
this
study,
we
utilized
plant-derived
blackcurrant
extract
(B)
as
natural
source
for
both
properties.
By
incorporating
B
into
G-O
crosslinked
through
Schiff
base
reaction
between
gelatin
(G)
oxidized
pullulan
(O),
resulting
G-
ACS Omega,
Год журнала:
2024,
Номер
9(10), С. 11860 - 11869
Опубликована: Фев. 26, 2024
Photothermal
nanocomposite
hydrogels
are
promising
materials
for
remotely
triggering
drug
delivery
by
near-infrared
(NIR)
radiation
stimuli.
In
this
work,
a
novel
hydrogel
based
on
poly(vinyl
alcohol),
methyl
ether-alt-maleic
acid),
ether),
and
functionalized
multiwalled
carbon
nanotubes
(MWCNT-f)
was
prepared
the
freeze/thaw
method.
A
comparative
characterization
of
(with
without
MWCNT-f)
carried
out
infrared
spectroscopy,
differential
scanning
calorimetry,
electron
microscopy,
mechanical
assays,
swelling
kinetics
measurements,
photothermal
analysis
under
NIR
irradiation.
Hydrophilic
chemotherapeutic
5-fluorouracil
(5-FU)
hydrophobic
ibuprofen
drugs
were
independently
loaded
into
hydrogels,
release
profiles
obtained
passive
NIR-irradiation
conditions.
The
concentration-dependent
cytotoxicity
studied
in
vitro
using
noncancerous
cells
cancer
cells.
Notable
changes
microstructure
physicochemical
properties
observed
adding
low
content
(0.2
wt
%)
MWCNT-f.
cumulative
amounts
5-FU
from
containing
MWCNT-f
significantly
increased
21
39%,
respectively,
through
application
short-term
irradiation
pulses.
Appropriate
concentrations
with
produced
affecting
overall
MWCNT-f-containing
its
behavior
make
it
an
attractive
material
to
promote
hydrophilic
drugs,
depending
treatment
requirements.
ACS Omega,
Год журнала:
2024,
Номер
9(24), С. 25575 - 25590
Опубликована: Июнь 4, 2024
Microbial
infection
diseases
are
a
major
threat
to
human
health
and
have
become
one
of
the
main
causes
mortality.
The
search
for
novel
antimicrobial
strategies
is
an
important
challenge
scientific
community,
considering
also
constant
increase
resistance
rise
new
diseases.
Among
combat
microbial
infections,
photothermal
effect
seems
be
most
promising.
Hyperthermia
effective
broad
spectrum
strategy
removal
infections.
all
reduce
diffusion
preparation
surfaces
primary
importance.
In
many
cases,
in
fact,
can
diffused
through
just
by
touching
them,
or
inoculating
microbes
internalizable
device,
such
as
implant,
prosthesis,
catheter.
this
review,
we
will
summarize
recent
advances
antibacterial
surfaces.
Materials Advances,
Год журнала:
2024,
Номер
5(4), С. 1454 - 1461
Опубликована: Янв. 1, 2024
2D-Ms
such
as
graphene,
C
3
N
4
,
and
MXene
have
attracted
significant
attention
due
to
their
excellent
physico-chemical
properties,
thereby
extensively
used
in
numerous
applications
including
biocidal
agents.
Biomacromolecules,
Год журнала:
2024,
Номер
25(4), С. 2486 - 2496
Опубликована: Март 1, 2024
Multifunctional
hydrogels
with
tissue
adhesion,
self-healing
behavior,
and
antibacterial
properties
have
potential
in
wound
healing
applications.
However,
their
inefficient
behavior
agents
can
cause
long-term
cytotoxicity
drug
resistance,
considerably
limiting
clinical
use.
Herein,
we
reported
a
PDA@LA
hydrogel
constructed
by
introducing
polydopamine
nanoparticles
(PDA-NPs)
into
high-density
dynamic
bonds
cross-linked
lipoic
acid
(LA)
that
was
formed
the
polymerization
of
LA.
Because
its
rich
carboxyl
groups,
LA
could
adhere
firmly
to
various
tissues.
Owing
bonds,
cut
exhibited
highly
recovered
uncut
state
after
for
10
min.
After
introduction
PDA-NPs,
able
heat
up
more
than
40
°C
kill
approximately
100%
Light‐assisted
3D
printing
technology,
which
uses
a
light
source
to
solidify
photopolymerizable
prepolymer
solution,
has
shown
great
potential
in
the
development
of
antibacterial
hydrogels
with
high‐resolution,
specific
features
and
functionalities.
3D‐printed
customized
structures
functions
are
widely
used
tissue
engineering,
regenerative
medicine,
wound
healing,
implants
advance
modeling
treatment
diseases.
In
current
review,
an
overview
light‐assisted
technologies
is
first
provided
for
hydrogels.
Novel
strategies
involving
integration
inorganic
nanomaterials,
antibiotics,
functional
polymers
into
enhancement
effects
then
discussed.
Finally,
perspective
advanced
design
using
artificial
intelligence
machine
learning
proposed,
providing
comprehensive
yet
succinct
examination
purposes.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(44)
Опубликована: Июль 29, 2024
Abstract
Healthcare‐associated
infections
remain
a
significant
health
concern,
particularly
with
the
emergence
of
antibiotic
resistance.
While
these
antibiotics
have
saved
countless
lives,
their
overuse
reduces
efficacy
promoting
multidrug‐resistant
(MDR)
bacteria.
This
prompts
researchers
to
explore
new
alternatives
for
treating
bacteria
proliferation.
In
this
context,
antibacterial
photodynamic
therapy
(aPDT)
has
emerged
as
promising
approach
localized
infections.
It
utilizes
reactive
oxygen
species
(ROS)
oxidative
stress
agents,
thereby
minimizing
risk
developing
MDR.
The
success
aPDT
significantly
hinges
on
careful
selection
photosensitizers
(PSs)
and
polymer
matrices
synthesis
polymer‐based
photoactive
materials.
Various
light‐absorbing
PSs
are
therefore
designed
enhancing
ROS
production
antimicrobial
efficacy.
By
incorporating
into
matrices,
materials
can
harness
light
power
generate
ROS,
destroying
bacterial
cells
upon
irradiation.
review
aims
provide
comprehensive
overview
advancements
in
field,
specifically
focusing
use
mechanism
four
main
generated
aPDT,
methods
used
detection,
mode
action
against
been
outlined.
recent
improvement
also
addressed.
Catalysis Science & Technology,
Год журнала:
2024,
Номер
14(7), С. 1703 - 1711
Опубликована: Янв. 1, 2024
The
synergistic
photocatalytic–photothermal
effect
realizes
more
effective
utilization
of
solar
energy,
which
can
be
used
in
the
fields
hydrogen
generation,
carbon
dioxide
reduction,
sterilization
and
membrane
separation.
