Materials & Design,
Год журнала:
2024,
Номер
244, С. 113153 - 113153
Опубликована: Июль 9, 2024
Protective
materials
that
can
ensure
the
safety
of
personnel
and
equipment
in
extreme
environments
have
a
wide
range
application
prospects,
such
as
outdoor
protective
clothing,
fire-fighting
etc.
However,
designing
highly
functional
is
still
considered
long-standing
challenge.
Herein,
superhydrophobic
oleophobic
fibrous
membranes
(SOFM)
prepared
by
electrospinning,
heat
treatment
spraying
techniques,
endowing
with
good
thermal
stability,
air
permeability
outstanding
repellence
to
liquids
water,
oil
low
surface
energy
solvents.
The
developed
SOFM
exhibits
integrated
properties
ethanol
intrusion
pressure
0.75
KPa,
excellent
1.54
mm/s,
water
vapor
transmission
rate
7.99
kg·m−2·d-1,
high
decomposition
temperature
330
℃,
tensile
strength
9.2
MPa.
Therefore,
effectively
protect
people
environments.
This
work
may
contribute
design
fiber
higher
protection
levels
field
clothing.
Regenerative Biomaterials,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 1, 2024
Abstract
A
dressing
patch
made
of
radially
oriented
poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
(PHBV)
nanofibers
was
successfully
manufactured
with
a
modified
electrospinning
strategy.
The
as-electrospun
PHBV
nanofiber
exhibited
uniform
and
bead-free
nanofibrous
morphology
innovative
arrangement,
which
demonstrated
to
possess
obviously
improved
mechanical
property,
increased
surface
hydrophilicity
enhanced
biological
properties
compared
the
control
traditionally
randomly
pattern.
Interestingly,
it
found
that
pattern
could
induce
cell
migration
from
periphery
center
along
in
rapid
manner.
To
further
improve
biofunction
patch,
berberine
(Beri,
an
isoquinoline
alkaloid)
two
different
concentrations
were
encapsulated
into
during
electrospinning,
present
sustained
drug
release
behavior
for
nearly
one
month.
Importantly,
addition
Beri
impart
excellent
anti-inflammatory
property
by
significantly
inhibiting
secretion
pro-inflammatory
factors
M1
macrophages,
also
showed
additive
influence
on
promoting
proliferation
human
dermal
fibroblasts
(HDFs),
as
well
growth
E.
coli,
S.
aureus
C.
albicans,
Beri-free
patch.
In
animal
studies,
electrospun
loading
high
content
accelerate
healing
process
diabetic
mouse
full-thickness
skin
wound
shortened
time
(100%
closure
rate
after
18
days’
treatment)
quality
(improved
collagen
deposition,
re-epithelialization
neovascularization
hair
follicles).
all,
this
study
reported
therapeutic
strategy
integrating
physical
cues
multiple
effective
treatment
hard-to-heal
wounds.
Materials & Design,
Год журнала:
2024,
Номер
244, С. 113145 - 113145
Опубликована: Июль 8, 2024
The
repair
of
secondary
critical
bone
defects
is
an
international
medical
challenge.
Bone
tissue
engineering
provides
methods
and
technology
for
repair.
regeneration
mechanism
serves
as
inspiration
the
material
structural
design
scaffolds.
In
terms
materials,
this
review
draws
from
biological
characteristics
host
cells
in
osteogenic
microenvironment
(including
osteoblast
lineage,
vascular
cell
inflammatory
cells,
etc.),
reviewing
regulatory
mechanisms
self-healing
proposing
autonomous
living
materials
scaffolds
which
prepared
by
in-situ
manufacturing.
Autonomous
regulate
migration,
proliferation
differentiation
real
time
releasing
steadily
long-term.
Regarding
structure,
we
functional
role
natural
structures
homeostasis,
providing
insights
into
bone-inspired
Due
to
conflict
between
mechanical
properties
ability,
proposes
assembled
They
can
prolong
half-life
provide
support
attachment
points
new
growth,
autonomously
microenvironment.
have
potential
advance
research
progress
field
pave
way
novel
clinical
treatments.
Journal of Applied Biomaterials & Functional Materials,
Год журнала:
2024,
Номер
22
Опубликована: Янв. 1, 2024
Nanofibrous
scaffolds
have
emerged
as
promising
candidates
for
localized
drug
delivery
systems
in
the
treatment
of
cutaneous
cancers.
In
this
study,
we
prepared
an
electrospun
nanofibrous
scaffold
incorporating
5-fluorouracil
(5-FU)
and
etoposide
(ETP)
chemotherapy
targeting
melanoma
cancer.
The
was
composed
polyvinyl
alcohol
(PVA)
chitosan
(CS),
via
electrospinning
process
loaded
with
chemotherapeutic
agents.
We
conducted
relevant
physicochemical
characterizations,
assessed
cytotoxicity,
evaluated
apoptosis
against
A375
cells.
5-FU/ETP
co-loaded
PVA/CS
exhibited
nanofibers
(NFs)
average
diameter
321
±
61
nm,
defect-free
homogenous
morphology.
FTIR
spectroscopy
confirmed
successful
incorporation
chemotherapeutics
into
scaffold.
Additionally,
demonstrated
a
hydrophilic
surface,
proper
mechanical
strength,
high
porosity,
efficient
liquid
absorption
capacity.
Notably,
sustained
controlled
release
observed
from
Furthermore,
significantly
increased
cytotoxicity
(95%)
(74%)
Consequently,
holds
promise
valuable
system
eradication
tumors
mitigation
adverse
reactions
associated
chemotherapy.
Abstract
Chronic
wounds,
as
a
kind
of
long‐term
disease
that
is
difficult
to
cure,
are
challenged
in
healthcare,
placing
substantial
physical,
emotional,
and
economic
burdens
on
patients
society.
Effective
treatment
chronic
wounds
essential
for
improving
patient
quality
life,
reducing
healthcare
costs,
alleviating
the
strain
medical
resources.
Hydrogel
materials
have
emerged
promising
candidates
wound
due
their
exceptional
adaptability
environments
ability
deliver
various
therapeutic
agents,
effectively
promoting
healing
wounds.
However,
wide
array
available
with
diverse
functionalities
presents
challenge
selecting
most
appropriate
components
synthesizing
hydrogel
dressings.
This
review
summarizes
common
materials,
including
properties,
cross‐linking
methods,
applications.
Additionally,
it
systematically
categorizes
different
elucidating
action
mechanisms
effects.
Furthermore,
this
work
offers
guidance
material
selection
dressing
design
based
characteristics
Finally,
challenges
future
perspectives
composite
hydrogels
field
dressings
discussed.
provides
readers
comprehensive
understanding
reliable
basis
synthesize
ideal
