Stimuli-Responsive Nanocomposite Hydrogels for Oral Diseases
Gels,
Год журнала:
2024,
Номер
10(7), С. 478 - 478
Опубликована: Июль 18, 2024
Oral
diseases
encompassing
conditions
such
as
oral
cancer,
periodontitis,
and
endodontic
infections
pose
significant
challenges
due
to
the
cavity's
susceptibility
pathogenic
bacteria
infectious
agents.
Saliva,
a
key
component
of
environment,
can
compromise
drug
efficacy
during
disease
treatment
by
diluting
formulations
reducing
drug-site
interactions.
Thus,
it
is
imperative
develop
effective
delivery
methods.
Stimuli-responsive
nanocomposite
hydrogels
offer
promising
solution
adapting
changes
in
environmental
states,
thereby
enabling
targeted
delivery.
These
smart
systems
have
potential
enhance
efficacy,
minimize
adverse
reactions,
reduce
administration
frequency,
improve
patient
compliance,
thus
facilitating
faster
recovery.
This
review
explores
various
types
stimuli-responsive
tailored
for
delivery,
with
specific
focus
on
their
applications
managing
diseases.
Язык: Английский
Evaluation of Drug Permeation Enhancement by Using In Vitro and Ex Vivo Models
Pharmaceuticals,
Год журнала:
2025,
Номер
18(2), С. 195 - 195
Опубликована: Янв. 31, 2025
Drugs
administered
by
means
of
extravascular
routes
drug
administration
must
be
absorbed
into
the
systemic
circulation,
which
involves
movement
molecules
across
biological
barriers
such
as
epithelial
cells
that
cover
mucosal
surfaces
or
stratum
corneum
covers
skin.
Some
drugs
exhibit
poor
permeation
membranes
may
experience
excessive
degradation
during
first-pass
metabolism,
tends
to
limit
their
bioavailability.
Various
strategies
have
been
used
improve
Absorption
enhancement
include
co-administration
chemical
enhancers,
enzymes,
and/or
efflux
transporter
inhibitors,
changes,
and
specialized
dosage
form
designs.
Models
with
physiological
relevance
are
needed
evaluate
efficacy
absorption
techniques.
in
vitro
cell
culture
models
ex
vivo
tissue
explored
quantify
effectiveness
strategies.
This
review
deliberates
on
use
for
evaluation
selected
including
nasal,
oromucosal,
pulmonary,
oral,
rectal,
transdermal
administration.
Язык: Английский
Environmental stimuli‐responsive hydrogels in endodontics: Advances and perspectives
International Endodontic Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
Abstract
Stimuli‐responsive
hydrogels
are
smart
and
functional
materials
that
respond
to
various
environmental
stimuli,
including
temperature,
light,
magnetic
field,
pH,
redox,
enzymes
glucose.
This
responsiveness
allows
for
the
controlled
release
of
therapeutic
agents
encapsulated
within
hydrogels,
enhancing
treatment
precision,
improving
outcomes
minimizing
side
effects.
Such
show
great
potential
in
root
canal
disinfection,
management
dental
pulp
inflammation
regeneration,
making
them
promising
candidates
more
personalized
effective
endodontic
treatments.
article
provides
an
overview
latest
advancements
design
application
stimuli‐responsive
endodontics,
emphasizing
their
revolutionize
It
also
addresses
current
challenges
explores
future
directions
aiming
inspire
motivate
researchers
further
engage
or
intensify
efforts
this
area
research.
Язык: Английский
Injectable depot-forming hydrogels for long-acting drug delivery
Elsevier eBooks,
Год журнала:
2025,
Номер
unknown, С. 241 - 272
Опубликована: Янв. 1, 2025
Synthesis and characterization of N-octanoyl glycol chitosan as a novel temperature and pH-sensitive injectable hydrogel for biomedical applications
Hien Pham,
Chanyang Joo,
Mst Jannatul Ferdous
и другие.
Materials & Design,
Год журнала:
2025,
Номер
254, С. 114052 - 114052
Опубликована: Май 5, 2025
Язык: Английский
Recent Advances in Polymer-Based Nanoformulations for Enhancing Oral Drug Delivery in Diabetes
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
100, С. 106119 - 106119
Опубликована: Авг. 27, 2024
Язык: Английский
Synthesis and characterization of self-healable supramolecular hydrogel based on carboxymethyl cellulose for biomedical applications
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
281, С. 136532 - 136532
Опубликована: Окт. 13, 2024
Язык: Английский
Research progress of piezoelectric materials in protecting oral health and treating oral diseases: a mini-review
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Сен. 13, 2024
Piezoelectric
materials,
as
a
class
of
materials
capable
generating
electrical
charges
under
mechanical
vibration,
have
special
piezoelectric
effects
and
been
widely
applied
in
various
disease
treatment
fields.
People
generate
vibrations
the
oral
cavity
during
daily
activities
such
brushing
teeth,
using
electric
toothbrushes,
chewing,
speaking.
These
natural
(or
external
ultrasound)
provide
ideal
conditions
for
activating
leading
to
their
high
potential
applications
protecting
health
treating
diseases.
Based
on
this,
this
review
reports
research
progress
trends
protection
diseases
past
5
years,
discusses
its
mechanism,
challenges
shortcomings,
aiming
theoretical
basis
new
ideas
future
application
field
cavity.
Finally,
brief
outlook
is
provided,
suggesting
that
may
enable
them
quickly
move
towards
real
clinical
applications.
Язык: Английский