Research progress of piezoelectric materials in protecting oral health and treating oral diseases: a mini-review DOI Creative Commons
Tingyu Yang, Rina Sa, Furong Wang

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 13, 2024

Piezoelectric materials, as a class of materials capable generating electrical charges under mechanical vibration, have special piezoelectric effects and been widely applied in various disease treatment fields. People generate vibrations the oral cavity during daily activities such brushing teeth, using electric toothbrushes, chewing, speaking. These natural (or external ultrasound) provide ideal conditions for activating leading to their high potential applications protecting health treating diseases. Based on this, this review reports research progress trends protection diseases past 5 years, discusses its mechanism, challenges shortcomings, aiming theoretical basis new ideas future application field cavity. Finally, brief outlook is provided, suggesting that may enable them quickly move towards real clinical applications.

Language: Английский

Stimuli-Responsive Nanocomposite Hydrogels for Oral Diseases DOI Creative Commons
Raffaele Conte, Anna Valentino, Silvia Romano

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(7), P. 478 - 478

Published: July 18, 2024

Oral diseases encompassing conditions such as oral cancer, periodontitis, and endodontic infections pose significant challenges due to the cavity's susceptibility pathogenic bacteria infectious agents. Saliva, a key component of environment, can compromise drug efficacy during disease treatment by diluting formulations reducing drug-site interactions. Thus, it is imperative develop effective delivery methods. Stimuli-responsive nanocomposite hydrogels offer promising solution adapting changes in environmental states, thereby enabling targeted delivery. These smart systems have potential enhance efficacy, minimize adverse reactions, reduce administration frequency, improve patient compliance, thus facilitating faster recovery. This review explores various types stimuli-responsive tailored for delivery, with specific focus on their applications managing diseases.

Language: Английский

Citations

6
Evaluation of Drug Permeation Enhancement by Using In Vitro and Ex Vivo Models DOI Creative Commons
Dewald Steyn, Anja Haasbroek‐Pheiffer, Wihan Pheiffer

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 195 - 195

Published: Jan. 31, 2025

Drugs administered by means of extravascular routes drug administration must be absorbed into the systemic circulation, which involves movement molecules across biological barriers such as epithelial cells that cover mucosal surfaces or stratum corneum covers skin. Some drugs exhibit poor permeation membranes may experience excessive degradation during first-pass metabolism, tends to limit their bioavailability. Various strategies have been used improve Absorption enhancement include co-administration chemical enhancers, enzymes, and/or efflux transporter inhibitors, changes, and specialized dosage form designs. Models with physiological relevance are needed evaluate efficacy absorption techniques. in vitro cell culture models ex vivo tissue explored quantify effectiveness strategies. This review deliberates on use for evaluation selected including nasal, oromucosal, pulmonary, oral, rectal, transdermal administration.

Language: Английский

Citations

0
Environmental stimuli‐responsive hydrogels in endodontics: Advances and perspectives DOI Creative Commons
He Liu, Ya Shen

International Endodontic Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract Stimuli‐responsive hydrogels are smart and functional materials that respond to various environmental stimuli, including temperature, light, magnetic field, pH, redox, enzymes glucose. This responsiveness allows for the controlled release of therapeutic agents encapsulated within hydrogels, enhancing treatment precision, improving outcomes minimizing side effects. Such show great potential in root canal disinfection, management dental pulp inflammation regeneration, making them promising candidates more personalized effective endodontic treatments. article provides an overview latest advancements design application stimuli‐responsive endodontics, emphasizing their revolutionize It also addresses current challenges explores future directions aiming inspire motivate researchers further engage or intensify efforts this area research.

Language: Английский

Citations

0
Injectable depot-forming hydrogels for long-acting drug delivery DOI
Lalitkumar K. Vora, B.H. Jaswanth Gowda,

Shilpkala Gade

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 241 - 272

Published: Jan. 1, 2025

Citations

0
Synthesis and characterization of N-octanoyl glycol chitosan as a novel temperature and pH-sensitive injectable hydrogel for biomedical applications DOI Creative Commons
Hien Pham,

Chanyang Joo,

Mst Jannatul Ferdous

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 114052 - 114052

Published: May 1, 2025

Language: Английский

Citations

0
Recent Advances in Polymer-Based Nanoformulations for Enhancing Oral Drug Delivery in Diabetes DOI
Sourbh Suren Garg,

Rajlaxmi Dey,

Atulika Sharma

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 106119 - 106119

Published: Aug. 27, 2024

Language: Английский

Citations

2
Synthesis and characterization of self-healable supramolecular hydrogel based on carboxymethyl cellulose for biomedical applications DOI
Mehran Kurdtabar,

Nazanin-Sadat Mirashrafi,

Gholam Bagheri Marandi

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136532 - 136532

Published: Oct. 13, 2024

Language: Английский

Citations

2
Research progress of piezoelectric materials in protecting oral health and treating oral diseases: a mini-review DOI Creative Commons
Tingyu Yang, Rina Sa, Furong Wang

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 13, 2024

Piezoelectric materials, as a class of materials capable generating electrical charges under mechanical vibration, have special piezoelectric effects and been widely applied in various disease treatment fields. People generate vibrations the oral cavity during daily activities such brushing teeth, using electric toothbrushes, chewing, speaking. These natural (or external ultrasound) provide ideal conditions for activating leading to their high potential applications protecting health treating diseases. Based on this, this review reports research progress trends protection diseases past 5 years, discusses its mechanism, challenges shortcomings, aiming theoretical basis new ideas future application field cavity. Finally, brief outlook is provided, suggesting that may enable them quickly move towards real clinical applications.

Language: Английский

Citations

0