Matter, Год журнала: 2023, Номер 6(3), С. 658 - 660
Опубликована: Март 1, 2023
Язык: Английский
Nano-Micro Letters, Год журнала: 2023, Номер 16(1)
Опубликована: Ноя. 30, 2023
Abstract Untethered micro/nanorobots that can wirelessly control their motion and deformation state have gained enormous interest in remote sensing applications due to unique characteristics various media diverse functionalities. Researchers are developing as innovative tools improve performance miniaturize systems, enabling situ detection of substances traditional methods struggle achieve. Over the past decade development, significant research progress has been made designing strategies based on micro/nanorobots, employing coordinated approaches. This review summarizes latest developments for by utilizing self-generated signals robots, robot behavior, microrobotic manipulation, robot-environment interactions. Providing recent studies relevant sensing, we also discuss challenges future perspectives facing micro/nanorobots-based intelligent platforms achieve complex environments, translating lab achievements into widespread real applications.
Язык: Английский
Процитировано
26
ACS Nano, Год журнала: 2023, Номер 17(23), С. 24343 - 24354
Опубликована: Дек. 1, 2023
Enzyme-catalyzed micro/nanomotors (MNMs) exhibit tremendous potential for biological isolation and sensing, because of their biocompatibility, versatility, ready access to biofuel. However, flow field generated by enzyme-catalyzed reactions might significantly hinder performance surface-linked functional moieties, e.g., the binding interaction between MNMs target cargos. Herein, we develop enzymatic micromotors with spatially selective distribution urease enable independent operation various modules facilitate capture sensing exosomes. When is modified into motors' cavity, from enzyme catalysis has little effect on exterior surface motors. The active motion encapsulating internally result in enhancement ∼35% 18% efficiency cargos, exosomes as an example here, compared static counterparts moving externally, respectively. Once are trapped, they can be transferred a clean environment motors Raman signal detection and/or identification using scattering (SERS) coated gold nanoshell. biocatalytic micromotors, achieving spatial separation driving module function module, offer considerable promise future design multifunctional biomedicine diagnostics.
Язык: Английский
Процитировано
14
Macromolecular Rapid Communications, Год журнала: 2023, Номер 44(17)
Опубликована: Май 29, 2023
Abstract Polymeric bowl‐shaped nanoparticles (BNPs) are anisotropic hollow structures with large openings on the surface, which have shown advantages such as high specific area and efficient encapsulation, delivery release of large‐sized cargoes demand compared to solid or closed structures. Several strategies been developed prepare BNPs based either template template‐free methods. For instance, despite widely used self‐assembly strategy, alternative methods including emulsion polymerization, swelling freeze‐drying polymeric spheres, template‐assisted approaches also developed. It is attractive but still challenging fabricate due their unique structural features. However, there no comprehensive summary up now, significantly hinders further development this field. In review, recent progress will be highlighted from perspectives design strategies, preparation methods, formation mechanisms, emerging applications. Moreover, future proposed.
Язык: Английский
Процитировано
11
Advanced Science, Год журнала: 2024, Номер 11(29)
Опубликована: Май 22, 2024
Abstract Artificial micro/nanomotors using active particles hold vast potential in applications such as drug delivery and microfabrication. However, upgrading them to micro/nanorobots capable of performing precise tasks with sophisticated functions remains challenging. Bubble microthruster (BMT) is introduced, a variation the bubble‐driven microrobot, which focuses energy from collapsing microbubble create an inertial impact on nearby target microparticles. Utilizing ultra‐high‐speed imaging, microparticle mass density determined sub‐nanogram resolution based relaxation time characterizing microparticle's transient response. Master curves BMT method are shown be dependent viscosity solution. The BMT, controlled by gamepad magnetic‐field guidance, precisely manipulates microparticles, including bioparticles. Validation involves measuring polystyrene hollow glass microsphere density, assessing mouse embryo densities. technique presents promising chip‐free, real‐time, highly maneuverable strategy that integrates bubble microrobot‐based manipulation bioparticle detection, can facilitate microscale characterizations growth monitoring.
Язык: Английский
Процитировано
3
Lab on a Chip, Год журнала: 2024, Номер 24(19), С. 4514 - 4535
Опубликована: Янв. 1, 2024
This review covers recent advances in the microfluidic preparation of small-scale robots.
Язык: Английский
Процитировано
3
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Янв. 13, 2025
Microrobots are poised to transform biomedicine by enabling precise, noninvasive procedures. However, current magnetic microrobots, composed of solid monolithic particles, present fundamental challenges in engineering intersubunit interactions, limiting their collective effectiveness navigating irregular biological terrains and confined spaces. To address this, we design hierarchically assembled microrobots with multiaxis mobility adaptability the potential interaction energy between subunits create stable, self-reconfigurable structures capable carrying protecting cargo internally. Using double emulsion templates control techniques, confine 10 nm iron oxide 15 silica nanoparticles within shell 100 μm microcapsules that form multiunit robotic collectives. Unexpectedly, find asymmetric localization enhances intercapsule energy, creating stable connections under rotating fields without altering susceptibility. These microcapsule collectives exhibit emergent behaviors, self-reconfiguring into kinematic chain-like traverse complex obstacles, arched confinements, adhesive, rugged tissues typically impede microscale systems. By harnessing these functions, demonstrate targeted antifungal delivery using a localized biofilm model on mucosal tissues, showing effective killing ofCandida binding or causing physical damage host cells. Our findings show how hierarchical assembly can produce cargo-carrying collective, self-adaptive for traversing environments, advancing biomedical applications.
Язык: Английский
Процитировано
0
Small Methods, Год журнала: 2025, Номер unknown
Опубликована: Март 11, 2025
Abstract Ensuring food quality and safety according to stringent global standards requires analytical procedures that are accurate, cost‐effective, efficient. This present innovative high‐throughput microrobots designed for the detection of antioxidants in samples. These consist photocatalytic bismuth subcarbonate anchored on silica‐coated magnetite nanoparticles. Upon exposure UV light, they generate reactive oxygen species via photocatalysis, which oxidize colorless dye into a green‐colored radical cation. The presence inhibits this reaction, allowing quantification antioxidant activity. magnetic Fe₃O₄/SiO₂ core enables steering using transverse rotating field, facilitating automated assays custom‐designed 3D‐printed sensing platform. results demonstrate these magneto‐photocatalytic can perform automated, assessments quality, representing significant advancement analysis technology.
Язык: Английский
Процитировано
0
Nanoscale, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
This review explores the self-propulsion mechanisms of chemically driven colloidal motors, principles their chemical communication, and strategies for directed assembly active superstructures.
Язык: Английский
Процитировано
0
Small Methods, Год журнала: 2025, Номер unknown
Опубликована: Май 12, 2025
Abstract Current nanoparticle‐based drug delivery systems for tumor therapy face significant challenges in intratumoral penetration and cellular internalization, leading to poor therapeutic efficacy. Herein, it is demonstrated that the sequential integration of glucose oxidase (GOx), catalase (CAT), urease (URE) onto half surface biotin‐modified Janus nanoparticles via chemical coupling way produces nanorobots multifunctionality synergistic effect (denoted as UCGPJNRs). They can autonomously powerfully move microenvironment (TME) by using endogenous urea a fuel, enabling penetrate deeper than 0.55 mm into tissues, ≈5.5‐fold previous counterparts. The UCGPJNRs perform motion‐enhanced biotin receptor‐mediated endocytosis endoplasmic reticulum/Golgi apparatus pathway‐mediated exocytosis, greatly improving internalization efficiency cells. release NH 3 when moving produce selective toxicity against cells hypoxic TME. Further, they enhance consumption ≈three times due motion‐accelerated GOx/CAT cascade reaction, disrupting metabolism on large area. After intratumorally injecting tumor‐bearing mice, significantly amplify vivo growth inhibition rate through their effect. This work provides plausible strategy overcome current limitations treatment anchoring multiple bioenzymes one nanoparticle.
Язык: Английский
Процитировано
0
Advanced Intelligent Systems, Год журнала: 2023, Номер 5(11)
Опубликована: Сен. 8, 2023
“On‐the‐fly” molecule enrichment by micro/nanomotors obviously improves heterogeneous catalysis, trace detection, and environmental monitoring, yet faces challenges of the trade‐off between collection range interaction time. Inspired versatile foraging process predators, this work demonstrates that micromotors doing spontaneous multipattern motion with microvortex can greatly enhance “on‐the‐fly” enrichment, demonstrated highly sensitive surface‐enhanced Raman scattering detection. It leverages an axis‐asymmetric bowl‐shaped structure nonlinear Ag–AgCl reaction, realizing alternating low‐velocity swinging forward accelerated steering motions for prolonged large area. Moreover, microstructure bestows a micro‐vortex above Ag side due to competition electric potential pressure gradient, also extending time during acceleration. Consequently, it exhibits at least order magnitude larger enhancement detection signals than counterparts. This proof‐of‐concept study highlights significance mode design in guiding flow field, offering substantial benefits applications.
Язык: Английский
Процитировано
8