Black Phosphorus-Loaded Separable Microneedles as Responsive Oxygen Delivery Carriers for Wound Healing

ACS Nano, Год журнала: 2020, Номер 14(5), С. 5901 - 5908

Опубликована: Апрель 21, 2020

Oxygen carriers are attracting extensive interest in biomedical research and clinical applications such as wound healing, alternative blood transfusion, acute trauma treatment. Great efforts have been devoted to the generation of oxygen with special functions properties meet specific demands. Here, we present black phosphorus (BP)-loaded separable responsive microneedles (MNs) carrying controllable delivering ability for healing. Such MNs composed a polyvinyl acetate (PVA) backing layer gelatin methacryloyl (GelMA) tips that loaded BP quantum dots (BP QDs) hemoglobin (Hb). Taking advantage fast dissolvability PVA, soon disappears after applied skin noncytotoxic, biocompatible GelMA left inside skin. Due excellent photothermal effect QDs reversible binding property Hb, local temperature will increase near-infrared ray irradiation, resulting release. Notably, practical performance has demonstrated by treating full-thickness cutaneous wounds type I diabetes rat model, indicating their potential value healing other related fields.

Язык: Английский

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Dynamic and reconfigurable materials from reversible network interactions

Nature Reviews Materials, Год журнала: 2022, Номер 7(7), С. 541 - 556

Опубликована: Янв. 31, 2022

Язык: Английский

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Self-healing polysaccharide-based injectable hydrogels with antibacterial activity for wound healing

Carbohydrate Polymers, Год журнала: 2021, Номер 275, С. 118770 - 118770

Опубликована: Окт. 18, 2021

Язык: Английский

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Magnesium Oxide Nanoparticle Coordinated Phosphate-Functionalized Chitosan Injectable Hydrogel for Osteogenesis and Angiogenesis in Bone Regeneration

ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 14(6), С. 7592 - 7608

Опубликована: Фев. 4, 2022

Natural polysaccharide (NPH)-based injectable hydrogels have shown great potential for critical-sized bone defect repair. However, their osteogenic, angiogenic, and mechanical properties are insufficient. Here, MgO nanoparticles (NPs) were incorporated into a newly synthesized water-soluble phosphocreatine-functionalized chitosan (CSMP) water solution to form an hydrogel (CSMP-MgO) via supramolecular combination between phosphate groups in CSMP magnesium NPs circumvent these drawbacks of chitosan-based hydrogels. Water-soluble deviate was first by grafting methacrylic anhydride phosphocreatine chain one-step lyophilization process. The this not only provides sites combine with binding but also serves as the reservoir control Mg2+ release. As result, lyophilized CSMP-MgO presented porous structure some small holes pore wall, diameters ranged from 50 100 μm. restricted swelling DI (lowest ratio 16.0 ± 1.1 g/g) no brittle failure during compression even at strain above 85% (maximum compressive strength 195.0 kPa) versus (28.0 41.3 kPa (0.5) hydrogels), regulated release stable sustained manner. promoted vitro calcium (hydroxyapatite (HA) tetracalcium (TTCP)) deposition supersaturated cytotoxicity MC3T3-E1 cells; cell osteogenic differentiation upregulation BSP, OPN, Osterix gene expression mineralization HUVEC tube formation. Among them, (5) most properties. Moreover, (CSMP-MgO (5)) showed excellent ability promote new formation calvarial defects rats. Thus, shows promise regeneration.

Язык: Английский

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Dual‐Crosslinked Dynamic Hydrogel Incorporating {Mo₁₅₄} with pH and NIR Responsiveness for Chemo‐Photothermal Therapy

Advanced Materials, Год журнала: 2021, Номер 33(40)

Опубликована: Авг. 11, 2021

Polyoxometalates are an emerging class of molecular clusters, with well-defined structures and chemical compositions that produced through simple, low-cost, highly reproducible methods. In particular, the wheel-shaped cluster {Mo

Язык: Английский

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Rational Design of Biomaterials to Potentiate Cancer Thermal Therapy

Chemical Reviews, Год журнала: 2023, Номер 123(11), С. 7326 - 7378

Опубликована: Март 13, 2023

Cancer thermal therapy, also known as hyperthermia has long been exploited to eradicate mass lesions that are now defined cancer. With the development of corresponding technologies and equipment, local therapies such radiofrequency ablation, microwave high-intensity focused ultrasound, have validated effectively ablate tumors in modern clinical practice. However, they still face many shortcomings, including nonspecific damages adjacent normal tissues incomplete ablation particularly for large tumors, restricting their wide usage. Attributed versatile physiochemical properties, biomaterials specially designed potentiate treatments according unique working principles. Meanwhile, biomaterial-based delivery systems able bridge with other types treatment strategies chemotherapy, radiotherapy immunotherapy. Therefore, this review, we discuss recent progress functional reinforce by functioning sensitizers endow more efficient tumor-localized and/or vehicles synergize therapeutic modalities combined cancer treatments. Thereafter, provide a critical perspective on further biomaterial-assisted toward applications.

Язык: Английский

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Multimaterial 3D and 4D Bioprinting of Heterogenous Constructs for Tissue Engineering

Advanced Materials, Год журнала: 2023, Номер 36(34)

Опубликована: Сен. 22, 2023

Additive manufacturing (AM), which is based on the principle of layer-by-layer shaping and stacking discrete materials, has shown significant benefits in fabrication complicated implants for tissue engineering (TE). However, many native tissues exhibit anisotropic heterogenous constructs with diverse components functions. Consequently, replication biomimetic using conventional AM processes a single material challenging. Multimaterial 3D 4D bioprinting (with time as fourth dimension) emerged promising solution constructing multifunctional that can mimic host microenvironment better than single-material alternatives. Notably, 4D-printed multimaterial architectures provide time-dependent programmable dynamic promote cell activity regeneration response to external stimuli. This paper first presents typical design strategies TE applications. Subsequently, latest are discussed, along their advantages challenges. In particular, potential smart highlighted. Furthermore, this review provides insights into how facilitate realization next-generation

Язык: Английский

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Injectable hydrogels for cartilage and bone tissue regeneration: A review

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 246, С. 125674 - 125674

Опубликована: Июль 4, 2023

Язык: Английский

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Injectable, High Specific Surface Area Cryogel Microscaffolds Integrated with Osteoinductive Bioceramic Fibers for Enhanced Bone Regeneration

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(17), С. 20661 - 20676

Опубликована: Апрель 21, 2023

Organic-inorganic composites with high specific surface area and osteoinductivity provide a suitable microenvironment for cell ingrowth effective ossification, which could greatly promote bone regeneration. Here, we report gelatin methacryloyl (GelMA) cryogel microspheres that are reinforced hydroxyapatite (HA) nanowires calcium silicate (CS) nanofibers to achieve the goal. The prepared composite open porous structure rough facilitate anchoring, simultaneously exhibiting excellent injectability. Compared only HA- or CS-containing counterparts, GelMA composited HA:CS (termed as GMHC) sustained release of bioactive Ca, P, Si elements, conducive osteogenic differentiation marrow mesenchymal stromal cells (BMSCs). These can prevent from forming peralkalic conditions, is beneficial growth. After injection into rat calvarial defects, neo-bone tissue grows their pores, showing tight integration. embedded bioceramic components significantly regeneration, GMHC achieving best regenerative outcomes. Promisingly, organic-inorganic microspheres, area, biodegradability, osteoinductivity, act injectable microscaffolds repair defects enhanced efficiency, may widen scaffold strategy engineering.

Язык: Английский

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Claw-inspired microneedle patches with liquid metal encapsulation for accelerating incisional wound healing

Chemical Engineering Journal, Год журнала: 2020, Номер 406, С. 126741 - 126741

Опубликована: Авг. 25, 2020

Язык: Английский

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