Bioinspired microneedle patches: Biomimetic designs, fabrication, and biomedical applications

Matter, Год журнала: 2022, Номер 5(2), С. 390 - 429

Опубликована: Фев. 1, 2022

Язык: Английский

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Ultrasound-triggered interfacial engineering-based microneedle for bacterial infection acne treatment

Science Advances, Год журнала: 2023, Номер 9(10)

Опубликована: Март 8, 2023

Acne is an inflammatory skin disease mainly caused by Propionibacterium acnes, which can cause local reactions and develop into chronic diseases in severe cases. To avoid the use of antibiotics to effectively treat site acne, we report a sodium hyaluronate microneedle patch that mediates transdermal delivery ultrasound-responsive nanoparticles for effective treatment acne. The contains formed zinc porphyrin-based metal-organic framework oxide (ZnTCPP@ZnO). We demonstrated activated oxygen-mediated killing P. acnes with antibacterial efficiency 99.73% under 15 min ultrasound irradiation, resulting decrease levels acne-related factors, including tumor necrosis factor-α, interleukins, matrix metalloproteinases. ions up-regulated DNA replication-related genes, promoting proliferation fibroblasts and, consequently, repair. This research leads highly strategy acne through interface engineering response.

Язык: Английский

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Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity

Nature Biomedical Engineering, Год журнала: 2022, Номер 6(2), С. 129 - 143

Опубликована: Янв. 10, 2022

Язык: Английский

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Multifunctional Silk Fibroin Methacryloyl Microneedle for Diabetic Wound Healing

Small, Год журнала: 2022, Номер 18(51)

Опубликована: Ноя. 4, 2022

Diabetic wound is one of the common complications in diabetic patients, which exhibits chronic, hard-to-heal characteristics. The healing process wounds impaired by several factors, including excessive oxidative stress, blocked angiogenesis, and bacterial infection. therapeutic effects traditional microneedle patches remain not satisfactory, due to their difficulty simultaneously targeting multiple targets treat wounds. As such, there an urgent need develop a multifunctional (MN) patch for promoting A MN with antioxidant, proangiogenesis, antibacterial capacities was fabricated target pathogenesis Silk fibroin methacryloyl, has excellent biocompatibility, stable mechanical properties, well processability, selected as base material patches. Prussian blue nanozymes (PBNs) vascular endothelial growth factor (VEGF) are encapsulated tips patches, Polymyxin layers Based on synergic properties these components, exhibit drug-sustained release, properties. developed accelerate healing, providing potential approach.

Язык: Английский

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Piezo‐Augmented and Photocatalytic Nanozyme Integrated Microneedles for Antibacterial and Anti‐Inflammatory Combination Therapy

Advanced Functional Materials, Год журнала: 2022, Номер 33(10)

Опубликована: Дек. 23, 2022

Abstract Wound infection is arguably the most common, and potentially devastating, complication of wound healing process. The ideal treatment strategy has to eliminate bacteria, alleviate inflammation, promote skin formation. Herein, a multifunctional heterostructure designed consisting ultrasmall platinum–ruthenium nanoalloys porous graphitic carbon nitride C 3 N 5 nanosheets (denoted as PtRu/C ), which concurrently possesses piezoelectric enhanced oxidase ‐mimic nanozyme activity photocatalytic hydrogen gas production capacity. Moreover, these hybrid nanotherapeutics are integrated in natural hyaluronic acid microneedles, exhibit almost 100% broad‐spectrum antibacterial efficacy against multiple bacterial strains vitro vivo within 10 min ultrasound treatment, effectively inhibit inflammation reactions after 1 h visible light irradiation, promising for accelerating cutaneous infected mice. This study highlights competitive development all‐in‐one anti‐inflammatory therapies.

Язык: Английский

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Rational Design of Intelligent and Multifunctional Dressing to Promote Acute/Chronic Wound Healing

ACS Applied Bio Materials, Год журнала: 2022, Номер 5(9), С. 4055 - 4085

Опубликована: Авг. 18, 2022

Currently, the clinic's treatment of acute/chronic wounds is still unsatisfactory due to lack functional and appropriate wound dressings. Intelligent multifunctional dressings are considered most advanced modalities. It essential design develop with required functions according microenvironment in clinical treatment. This work summarizes characteristics various common wounds, such as acute wound, diabetic burns scalded mucosal ulcers wound. Furthermore, factors transformation from chronic were analyzed. Then we focused on summarizing how researchers fully thoroughly combined complex modern technology ensure usability value dressing, photothermal-sensitive dressings, dressing (pH-sensitive ROS-sensitive osmotic pressure dressings), hemostatic guiding tissue regeneration microneedle 3D/4D printing Finally, revolutionary development transform existing into needs soon possible have carried out a reasonable meaningful outlook.

Язык: Английский

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Design principles of microneedles for drug delivery and sampling applications

Materials Today, Год журнала: 2022, Номер 63, С. 137 - 169

Опубликована: Ноя. 17, 2022

Язык: Английский

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Recent Progress in Microneedles‐Mediated Diagnosis, Therapy, and Theranostic Systems

Advanced Healthcare Materials, Год журнала: 2022, Номер 11(10)

Опубликована: Янв. 16, 2022

Abstract Theranostic system combined diagnostic and therapeutic modalities is critical for the real‐time monitoring of disease‐related biomarkers personalized therapy. Microneedles, as a multifunctional platform, are promising transdermal diagnostics drug delivery. They have shown attractive properties including painless skin penetration, easy self‐administration, prominent effects, good biosafety. Herein, an overview microneedles‐based diagnosis, therapies, theranostic systems given. Four detection methods concluded based on sensing mechanism: i) electrochemistry, ii) fluorometric, iii) colorimetric, iv) Raman methods. Additionally, robust microneedles suitable implantable Microneedles‐assisted delivery can be primarily classified passive, active, responsive release, release mechanisms. oral mechanisms also presented in this review. Furthermore, key frontier developments microneedles‐mediated major selling points emphasized These into open‐loop closed‐loop indirectness directness feedback between diagnosis therapy, respectively. Finally, conclusions future perspectives next‐generation discussed. Taken together, microneedle‐based new avenue disease‐specific applications.

Язык: Английский

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Dissolvable polymer microneedles for drug delivery and diagnostics

Journal of Controlled Release, Год журнала: 2022, Номер 347, С. 561 - 589

Опубликована: Май 24, 2022

Язык: Английский

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Microneedle biomedical devices

Nature Reviews Bioengineering, Год журнала: 2023, Номер 2(4), С. 324 - 342

Опубликована: Дек. 21, 2023

Язык: Английский

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