Sex-related immunity: could Toll-like receptors be the answer in acute inflammatory response? DOI Creative Commons

Alexandros Popotas,

Georges Casimir, Francis Corazza

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Май 21, 2024

An increasing number of studies have highlighted the existence a sex-specific immune response, wherein men experience worse prognosis in cases acute inflammatory diseases. Initially, this sex-dependent response was attributed to influence sex hormones. However, growing body evidence has shifted focus toward chromosomes rather than hormones shaping these disparities. Notably, certain pattern recognition receptors, such as Toll-like receptors (TLRs), and their associated pathways been implicated driving response. These are encoded by genes located on X chromosome. TLRs pivotal components innate system, playing crucial roles responding infectious diseases, including bacterial viral pathogens, well trauma-related conditions. Importantly, TLR-mediated responses, indicated production specific proteins cytokines, exhibit discernible patterns. In review, we delve into subject bias TLR activation explore its clinical implications relatively both chromosome hormonal environment. The overarching objective is enhance our understanding fundamental mechanisms underlying differences.

Язык: Английский

Risks of and risk factors for COVID-19 disease in people with diabetes: a cohort study of the total population of Scotland DOI Creative Commons
Stuart J. McGurnaghan, Amanda Weir,

Jen Bishop

и другие.

The Lancet Diabetes & Endocrinology, Год журнала: 2020, Номер 9(2), С. 82 - 93

Опубликована: Дек. 24, 2020

Язык: Английский

Процитировано

320
A retrospective case-control study on menstrual cycle changes following COVID-19 vaccination and disease DOI Creative Commons
Alexandra Alvergne, Gabriella Kountourides,

M. Austin Argentieri

и другие.

iScience, Год журнала: 2023, Номер 26(4), С. 106401 - 106401

Опубликована: Март 15, 2023

There has been increasing public concern that COVID-19 vaccination causes menstrual disturbance regarding the relative effect of compared to SARS-CoV-2 infection. Our objectives were test potential risk factors for reporting cycle changes following and compare parameters disease. We performed a secondary analysis retrospective online survey conducted in UK March 2021. In pre-menopausal vaccinated participants (n = 4,989), 18% reported after their first vaccine injection. The prevalence any was higher women who smoke, have history disease, or are not using estradiol-containing contraceptives. second sample including both unvaccinated 12,579), alone associated with abnormal parameters, while disease an increased heavier bleeding, "missed" periods, inter-menstrual bleeding.

Язык: Английский

Процитировано

71
The conneXion between sex and immune responses DOI
Katherine S. Forsyth, Nikhil Jiwrajka, Claudia D. Lovell

и другие.

Nature reviews. Immunology, Год журнала: 2024, Номер 24(7), С. 487 - 502

Опубликована: Фев. 21, 2024

Язык: Английский

Процитировано

66
Incidence of New-Onset Hypertension Post–COVID-19: Comparison With Influenza DOI
Vincent Zhang, Molly Fisher, Wei Hou

и другие.

Hypertension, Год журнала: 2023, Номер 80(10), С. 2135 - 2148

Опубликована: Авг. 21, 2023

SARS-CoV-2 may trigger new-onset persistent hypertension. This study investigated the incidence and risk factors associated with hypertension during COVID-19 hospitalization at ≈6-month follow-up compared influenza.This retrospective observational was conducted in a major academic health system New York City. Participants included 45 398 patients (March 2020 to August 2022) 13 864 influenza (January 2018 without history of hypertension.At 6-month follow-up, seen 20.6% hospitalized 10.85% nonhospitalized COVID-19. Persistent among did not vary across pandemic, whereas that decreased from 20% March ≈10% October (R2=0.79, P=0.003) then plateaued thereafter. Hospitalized were 2.23 ([95% CI, 1.48-3.54]; P<0.001) times 1.52 1.22-1.90]; P<0.01) more likely develop than counterparts. common older adults, males, Black, preexisting comorbidities (chronic obstructive pulmonary disease, coronary artery chronic kidney disease), those who treated pressor corticosteroid medications. Mathematical models predicted 79% 86% accuracy. In addition, 21.0% no prior developed hospitalization.Incidence is higher influenza, constituting burden given sheer number Screening at-risk for following illness be warranted.

Язык: Английский

Процитировано

61
Patterns and predictors of sick leave after Covid-19 and long Covid in a national Swedish cohort DOI Creative Commons
Emma Westerlind, Annie Palstam, Katharina S. Sunnerhagen

и другие.

BMC Public Health, Год журнала: 2021, Номер 21(1)

Опубликована: Май 31, 2021

Abstract Background The impact of Covid-19 and its long-term consequences is not yet fully understood. Sick leave can be seen as an indicator health in a working age population, the present study aimed to investigate sick-leave patterns after Covid-19, potential factors predicting longer sick hospitalised non-hospitalised people with Covid-19. Methods comprehensive national registry-based Sweden 4-month follow-up. All who started receive sickness benefits for during March 1 August 31, 2020, were included. Predictors ≥1 month long Covid (≥12 weeks) analysed logistic regression total population separate models depending on inpatient care due Results A 11,955 within inclusion period. median was 35 days, 13.3% Covid, 9.0% remained whole follow-up There 2960 received which strongest predictor leave. year prior older also predicted No clear pattern socioeconomic noted. Conclusions substantial number are may protracted, quite common. severity (needing care), leave, all seem predict likelihood However, no factor could clearly indicating complexity this condition. group needing seems heterogeneous, knowledge gap.

Язык: Английский

Процитировано

102
COVID-19: Understanding Inter-Individual Variability and Implications for Precision Medicine DOI Open Access
Naveen L. Pereira, Ferhaan Ahmad, Mirnela Byku

и другие.

Mayo Clinic Proceedings, Год журнала: 2020, Номер 96(2), С. 446 - 463

Опубликована: Дек. 3, 2020

Язык: Английский

Процитировано

84
COVID-19 vaccination and menstrual cycle changes: A United Kingdom (UK) retrospective case-control study DOI Creative Commons
Alexandra Alvergne, Gabriella Kountourides, M. Austin Argentieri

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2021, Номер unknown

Опубликована: Ноя. 23, 2021

Abstract Background There has been increasing public concern that COVID-19 vaccines cause menstrual cycle disturbances, yet there is currently limited data to evaluate the impact of vaccination on health. Our objectives were (1) prevalence changes following against COVID-19, (2) test potential risk factors for any such changes, and (3) identify patterns symptoms in participants’ written accounts. Methods We performed a secondary analysis retrospective online survey titled “The Covid-19 Pandemic Women’s Reproductive Health”, conducted March 2021 UK before widespread media attention regarding impacts SARS-CoV-2 menstruation. Participants recruited via Facebook ad campaign eligibility criteria completion age greater than 18 years, having ever menstruated living UK. In total, 26,710 people gave consent completed survey. For this we selected 4,989 participants who pre-menopausal vaccinated. These aged 28 43, predominantly from England (81%), white background (95%) not using hormonal contraception (58%). Findings Among vaccinated individuals (n=4,989), 80% did report up 4 months after their first vaccine injection. Current use combined oral contraceptives was associated with lower odds reporting by 48% (OR = 0.52, 95CI [0.34 0.78], P <0.001). Odds increased 44% current smokers 1.44, [1.07 1.94], <0.01) more 50% positive COVID status [Long Covid 1.61, [1.28 2.02], <0.001), acute 1.54, [1.27 1.86], <0.001)]. The effects remain adjusting self-reported magnitude over year preceding Written accounts diverse symptoms; most common words include “cramps”, “late”, “early”, “spotting”, “heavy” “irregular”, low level clustering among them. Conclusions Following disturbance occurred 20% sample. Out 33 variables investigated, smoking previous history infection found be while oestradiol-containing protective factor. Diverse experiences reported, bleeding cessation heavy bleeding.

Язык: Английский

Процитировано

78
Sex and gender differences in COVID-19: More to be learned! DOI Creative Commons
Lina Ya’qoub, Islam Y. Elgendy, Carl J. Pepine

и другие.

American Heart Journal Plus Cardiology Research and Practice, Год журнала: 2021, Номер 3, С. 100011 - 100011

Опубликована: Март 1, 2021

The COVID-19 pandemic has affected millions of patients across the globe. Multiple studies, national and international governmental data have shown important sex gender differences in incidence outcomes with COVID-19. These are not only attributed to age comorbid conditions but likely a combination factors, including hormonal differences, immune response, inflammatory markers behavioral attitudes, among others. In this review, we discuss studies addressing sex- gender-specific infections focus on potential pathophysiological mechanisms these differences.

Язык: Английский

Процитировано

64
COVID-19 complications in males and females: recent developments DOI
Rahul Chaturvedi,

Briana Lui,

Jamie A Aaronson

и другие.

Journal of Comparative Effectiveness Research, Год журнала: 2022, Номер 11(9), С. 689 - 698

Опубликована: Май 5, 2022

Aim: To provide a comprehensive understanding of the varying effects SARS-CoV-2 infection based on sex. Methods: A PubMed search 470 primary articles was performed, with inclusion relevance (sex differences discussed in target COVID population) and redundancy. queried title for keywords "SEX" "COVID" or "SARS" between 2020 2022. Results: For COVID-19, males have increased risk infectivity intensive care unit admission worse overall outcomes compared females. Genetic predispositions, sex hormones, immune system responses non-biological causes all contribute to disparity COVID-19 sexes. sex-related determinants morbidity mortality remain unclear. Conclusions: Male is factor several related COVID-19. Investigating impact an important part behavior disease. Future work needed further explore these relationships optimize management patients

Язык: Английский

Процитировано

41
Male reproductive health after 3 months from SARS-CoV-2 infection: a multicentric study DOI Creative Commons
Donatella Paoli, Francesco Pallotti,

Antonella Anzuini

и другие.

Journal of Endocrinological Investigation, Год журнала: 2022, Номер 46(1), С. 89 - 101

Опубликована: Авг. 9, 2022

Abstract Purpose While SARS-CoV-2 infection appears not to be clinically evident in the testes, indirect inflammatory effects and fever may impair testicular function. To date, few long-term data of semen parameters impairment after recovery comprehensive andrological evaluation recovered patients has been published. The purpose this study was investigate whether affect male reproductive health. Methods Eighty were recruited three months COVID-19 recovery. They performed physical examination, ultrasound, analysis, sperm DNA integrity (TUNEL), anti-sperm antibodies (ASA) testing, sex hormone profile (Total testosterone, LH, FSH). In addition, all administered International Index Erectile Function questionnaire (IIEF-15). Sperm compared with two age-matched healthy pre-COVID-19 control groups normozoospermic (CTR1) primary infertile (CTR2) subjects. Results Median values from subjects within WHO 2010 fifth percentile. Mean percentage fragmentation (%SDF) 14.1 ± 7.0%. Gelatin Agglutination Test ( GAT ) positive 3.9% blood serum samples, but no plasma sample found. Only five (6.2%) had total testosterone levels below laboratory reference range. bilateral volume 31.5 9.6 ml. dysfunction detected 30% Conclusion Our remark that does seem cause direct damage function, while transient. It is possible counsel couples postpone research parenthood or ART procedures around infection.

Язык: Английский

Процитировано

41