Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines
Aging,
Год журнала:
2023,
Номер
unknown
Опубликована: Июнь 29, 2023
Depression
and
obesity
are
both
common
disorders
currently
affecting
public
health,
frequently
occurring
simultaneously
within
individuals,
the
relationship
between
these
is
bidirectional.
The
association
depression
highly
co-morbid
tends
to
significantly
exacerbate
metabolic
related
depressive
symptoms.
However,
neural
mechanism
under
mutual
control
of
largely
inscrutable.
This
review
focuses
particularly
on
alterations
in
systems
that
may
mechanistically
explain
vivo
homeostatic
regulation
link,
such
as
immune-inflammatory
activation,
gut
microbiota,
neuroplasticity,
HPA
axis
dysregulation
well
neuroendocrine
regulators
energy
metabolism
including
adipocytokines
lipokines.
In
addition,
summarizes
potential
future
treatments
for
raises
several
questions
need
be
answered
research.
will
provide
a
comprehensive
description
localization
biological
connection
better
understand
co-morbidity
depression.
Язык: Английский
Omentin-1, a Protective Adipokine for Irritable Bowel Syndrome
Yanping Gao,
Chen Chen,
Xijing Huang
и другие.
Journal of Inflammation Research,
Год журнала:
2025,
Номер
Volume 18, С. 1689 - 1701
Опубликована: Фев. 1, 2025
Introduction:
Irritable
bowel
syndrome
(IBS)
is
characterized
by
patients'
high
level
of
suffering.
There
increasing
evidence
for
involvement
the
immune
system
in
this
disease.
Adipokines
have
been
reported
to
be
critical
immunoregulators
many
clinical
conditions,
including
gastrointestinal
(GI)
inflammatory
diseases.
Our
study
aimed
investigate
associations
omentin-1
(a
newly
discovered
adipokine)
with
IBS.
Methods:
In
current
study,
serum
levels
were
measured
209
patients
IBS
(including
three
subtypes)
and
188
healthy
controls
enzyme-linked
immunosorbent
assay
(ELISA).
The
somatic
symptoms
determined
5-item
severity
score
(IBS-SSS),
quality
life
(QOL)
34-item
IBS-QOL
questionnaire,
psychological
disorders
Patient
Health
Questionnaire
(PHQ-9),
Hospital
Anxiety
Depression
Scale
(HADS),
Visceral
Sensitivity
Index
(VSI).
Therapeutic
effect
was
investigated
a
2,4,6-trinitrobenzenesulfonic
acid
(TNBS)-induced
mouse
model.
Results:
We
found
that
significantly
decreased
diarrhea-predominant
(IBS-D)
subtype
(not
constipation
or
alternating
subtype)
compared
those
subjects.
Patients
lower
suffered
from
higher
(abdominal
pain
distention,
flatulence,
rumbling),
QOL,
worse
status.
one-year
follow-up,
showed
potential
reflect
disease
progression.
Additionally,
accompanied
pro-inflammatory
cytokine
concentrations
IBS-D.
Supplement
protective
against
visceral
hypersensitivity
mucosal
inflammation
an
Discussion:
findings
highlight
value
as
innovative
biomarker
IBS,
emphasizing
its
significance
improving
treatment
management
Keywords:
irritable
syndrome,
adipokine,
omentin-1,
symptoms,
life,
Язык: Английский
The Role of Adipokines in the Pathologies of the Central Nervous System
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(19), С. 14684 - 14684
Опубликована: Сен. 28, 2023
Adipokines
are
protein
hormones
secreted
by
adipose
tissue
in
response
to
disruptions
physiological
homeostasis
within
the
body’s
systems.
The
regulatory
functions
of
adipokines
central
nervous
system
(CNS)
multifaceted
and
intricate,
they
have
been
identified
a
number
pathologies.
Therefore,
specific
potential
be
used
as
biomarkers
for
screening
purposes
neurological
dysfunctions.
systematic
review
presented
herein
focuses
on
analysis
various
pathogenesis
CNS
diseases.
Thirteen
proteins
were
selected
through
scientific
databases.
It
was
found
that
these
can
cerebrospinal
fluid
either
their
ability
modify
molecular
complex
cross
blood–brain
barrier
or
being
endogenously
produced
itself.
As
result,
this
correlate
with
measurability
during
pathological
processes,
including
Alzheimer’s
disease,
amyotrophic
lateral
sclerosis,
multiple
depression,
brain
tumors.
Язык: Английский
Acid sphingomyelinase modulates anxiety-like behavior likely through toll-like receptor signaling pathway
Molecular Brain,
Год журнала:
2025,
Номер
18(1)
Опубликована: Фев. 4, 2025
Abstract
Recent
studies
have
shown
that
abnormal
activity
of
acid
sphingomyelinase
(Asm)
has
been
associated
with
a
range
psychiatric
disorders
including
schizophrenia
and
depression.
However,
the
role
Asm
in
regulation
anxiety
remains
unclear.
In
present
study,
we
employed
Asm-knockout
(Asm
KO)
mice
to
investigate
association
between
using
behavioral
tests,
RNA
sequencing,
q-PCR,
immunohistochemical
staining,
other
methods.
The
results
showed
KO
exhibit
enhanced
anxiety-like
behaviors,
such
as
restricted
activity,
reduced
cumulative
times
central
area,
diminished
exploratory
interest,
delayed
latency
feed,
through
tests
open
field,
novelty-suppressed
feeding
test,
elevated
plus
maze
ect.
Transcriptional
profiling
combined
bioinformatics
analysis
revealed
upregulation
Toll-like
receptor
signaling
pathway
related
gene
Tlr1/2,
Ccl3,
Ccl4,
Ccl5
Cd86
mice,
which
was
further
confirmed
by
detection
activated
microglia
astrocytes
iba-1
GFAP
staining.
Collectively,
our
findings
uncover
for
regulating
behavior
suggest
it
may
be
essential
maintenance
emotional
stability,
indicating
its
potential
promising
target
treating
disorders.
Язык: Английский
Pleiotropic Role of mGluR7/MAPK Signaling in the Protection of Intelectin-1 against Cerebral Ischemia-reperfusion Injury
Pharmacological Research,
Год журнала:
2025,
Номер
unknown, С. 107735 - 107735
Опубликована: Апрель 1, 2025
Язык: Английский
Omentin-1 attenuates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal ligament stem cells and reduces M1 macrophages polarization through repressing endoplasmic reticulum stress
Prostaglandins & Other Lipid Mediators,
Год журнала:
2024,
Номер
174, С. 106882 - 106882
Опубликована: Авг. 14, 2024
Язык: Английский
Microglia in physiological conditions and the importance of understanding their homeostatic functions in the arcuate nucleus
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 4, 2024
Microglia
are
highly
dynamic
cells
that
have
been
mainly
studied
under
pathological
conditions.
The
present
review
discusses
the
possible
implication
of
microglia
as
modulators
neuronal
electrical
responses
in
physiological
conditions
and
hypothesizes
how
these
might
modulate
hypothalamic
circuits
health
during
obesity.
Microglial
diverse,
depending
on
developmental
stage
brain
region.
evidence
also
suggests
activity
modulates
microglial
motility
to
control
excitability.
Additionally,
we
show
expression
genes
associated
with
neuron-microglia
interaction
is
down-regulated
obese
mice
compared
control-fed
mice,
suggesting
an
alteration
contact-dependent
mechanisms
sustain
arcuate-median
eminence
function.
We
discuss
microglial-derived
signals
for
excitability
neurons
homeostasis
This
emphasizes
importance
studying
interplay
between
maintain
proper
circuit
It
aims
elucidate
disruptions
normal
activities
can
adversely
affect
health.
Язык: Английский
Inflammation-Involved Proteins in Blood Serum of Cataract Patients—A Preliminary Study
Biomedicines,
Год журнала:
2023,
Номер
11(10), С. 2607 - 2607
Опубликована: Сен. 22, 2023
Approximately
50%
of
all
global
blindness
is
caused
by
cataract
in
adults
aged
≥50
years.
The
mechanisms
the
disease
are
most
arguably
related
to
a
redox
imbalance
and
inflammation;
therefore,
aim
study
was
evaluate
processes
associated
with
inflammation
patients.
Twenty-four
patients
22-60
years
(62.5%
females)
participated
study,
33
controls
28-60
(66.7%
females).
Venous
blood
serum
subjects
examined
for
alpha
1-antitrypsin,
as
well
selected
lysosomal
enzymes
adipokines.
activities
enzymes,
activity
1-antitrypsin
concentrations
c-reactive
protein
leptin,
were
similar
versus
controls.
interleukin
6
resistin
lower,
turn,
whereas
omentin-1
adiponectin
higher.
Moreover,
revealed
existence
many
linear
relationships
between
parameters,
including
multiple
regression,
especially
gender-wise.
No
systemic
probably
noted
tested;
nevertheless,
deregulation
adiponectin,
secretion
observed.
Язык: Английский