Inflammation-Involved Proteins in Blood Serum of Cataract Patients—A Preliminary Study DOI Creative Commons
Paweł Sutkowy, Hanna Lesiewska‐Junk, Alina Woźniak

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2607 - 2607

Published: Sept. 22, 2023

Approximately 50% of all global blindness is caused by cataract in adults aged ≥50 years. The mechanisms the disease are most arguably related to a redox imbalance and inflammation; therefore, aim study was evaluate processes associated with inflammation patients. Twenty-four patients 22-60 years (62.5% females) participated study, 33 controls 28-60 (66.7% females). Venous blood serum subjects examined for alpha 1-antitrypsin, as well selected lysosomal enzymes adipokines. activities enzymes, activity 1-antitrypsin concentrations c-reactive protein leptin, were similar versus controls. interleukin 6 resistin lower, turn, whereas omentin-1 adiponectin higher. Moreover, revealed existence many linear relationships between parameters, including multiple regression, especially gender-wise. No systemic probably noted tested; nevertheless, deregulation adiponectin, secretion observed.

Language: Английский

Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines DOI Creative Commons

Xiying Fu,

Yicun Wang, Fangyi Zhao

et al.

Aging, Journal Year: 2023, Volume and Issue: unknown

Published: June 29, 2023

Depression and obesity are both common disorders currently affecting public health, frequently occurring simultaneously within individuals, the relationship between these is bidirectional. The association depression highly co-morbid tends to significantly exacerbate metabolic related depressive symptoms. However, neural mechanism under mutual control of largely inscrutable. This review focuses particularly on alterations in systems that may mechanistically explain vivo homeostatic regulation link, such as immune-inflammatory activation, gut microbiota, neuroplasticity, HPA axis dysregulation well neuroendocrine regulators energy metabolism including adipocytokines lipokines. In addition, summarizes potential future treatments for raises several questions need be answered research. will provide a comprehensive description localization biological connection better understand co-morbidity depression.

Language: Английский

Citations

33
Omentin-1, a Protective Adipokine for Irritable Bowel Syndrome DOI Creative Commons

Yanping Gao,

Chen Chen,

Xijing Huang

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1689 - 1701

Published: Feb. 1, 2025

Introduction: Irritable bowel syndrome (IBS) is characterized by patients' high level of suffering. There increasing evidence for involvement the immune system in this disease. Adipokines have been reported to be critical immunoregulators many clinical conditions, including gastrointestinal (GI) inflammatory diseases. Our study aimed investigate associations omentin-1 (a newly discovered adipokine) with IBS. Methods: In current study, serum levels were measured 209 patients IBS (including three subtypes) and 188 healthy controls enzyme-linked immunosorbent assay (ELISA). The somatic symptoms determined 5-item severity score (IBS-SSS), quality life (QOL) 34-item IBS-QOL questionnaire, psychological disorders Patient Health Questionnaire (PHQ-9), Hospital Anxiety Depression Scale (HADS), Visceral Sensitivity Index (VSI). Therapeutic effect was investigated a 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced mouse model. Results: We found that significantly decreased diarrhea-predominant (IBS-D) subtype (not constipation or alternating subtype) compared those subjects. Patients lower suffered from higher (abdominal pain distention, flatulence, rumbling), QOL, worse status. one-year follow-up, showed potential reflect disease progression. Additionally, accompanied pro-inflammatory cytokine concentrations IBS-D. Supplement protective against visceral hypersensitivity mucosal inflammation an Discussion: findings highlight value as innovative biomarker IBS, emphasizing its significance improving treatment management Keywords: irritable syndrome, adipokine, omentin-1, symptoms, life,

Language: Английский

Citations

1
Acid sphingomyelinase modulates anxiety-like behavior likely through toll-like receptor signaling pathway DOI Creative Commons
Hongjie Yu, Yanan Xu, Hailun Jiang

et al.

Molecular Brain, Journal Year: 2025, Volume and Issue: 18(1)

Published: Feb. 4, 2025

Abstract Recent studies have shown that abnormal activity of acid sphingomyelinase (Asm) has been associated with a range psychiatric disorders including schizophrenia and depression. However, the role Asm in regulation anxiety remains unclear. In present study, we employed Asm-knockout (Asm KO) mice to investigate association between using behavioral tests, RNA sequencing, q-PCR, immunohistochemical staining, other methods. The results showed KO exhibit enhanced anxiety-like behaviors, such as restricted activity, reduced cumulative times central area, diminished exploratory interest, delayed latency feed, through tests open field, novelty-suppressed feeding test, elevated plus maze ect. Transcriptional profiling combined bioinformatics analysis revealed upregulation Toll-like receptor signaling pathway related gene Tlr1/2, Ccl3, Ccl4, Ccl5 Cd86 mice, which was further confirmed by detection activated microglia astrocytes iba-1 GFAP staining. Collectively, our findings uncover for regulating behavior suggest it may be essential maintenance emotional stability, indicating its potential promising target treating disorders.

Language: Английский

Citations

0
Pleiotropic Role of mGluR7/MAPK Signaling in the Protection of Intelectin-1 against Cerebral Ischemia-reperfusion Injury DOI Creative Commons
Xiaochen Niu, Bodong Wang,

Aizhen Zhao

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107735 - 107735

Published: April 1, 2025

Language: Английский

Citations

0
The Role of Adipokines in the Pathologies of the Central Nervous System DOI Open Access
Korbinian Huber, Emilia Szerenos,

Dawid Lewandowski

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14684 - 14684

Published: Sept. 28, 2023

Adipokines are protein hormones secreted by adipose tissue in response to disruptions physiological homeostasis within the body’s systems. The regulatory functions of adipokines central nervous system (CNS) multifaceted and intricate, they have been identified a number pathologies. Therefore, specific potential be used as biomarkers for screening purposes neurological dysfunctions. systematic review presented herein focuses on analysis various pathogenesis CNS diseases. Thirteen proteins were selected through scientific databases. It was found that these can cerebrospinal fluid either their ability modify molecular complex cross blood–brain barrier or being endogenously produced itself. As result, this correlate with measurability during pathological processes, including Alzheimer’s disease, amyotrophic lateral sclerosis, multiple depression, brain tumors.

Language: Английский

Citations

8
Omentin-1 attenuates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal ligament stem cells and reduces M1 macrophages polarization through repressing endoplasmic reticulum stress DOI

Yan Yang,

Lirong Chen

Prostaglandins & Other Lipid Mediators, Journal Year: 2024, Volume and Issue: 174, P. 106882 - 106882

Published: Aug. 14, 2024

Language: Английский

Citations

2
Microglia in physiological conditions and the importance of understanding their homeostatic functions in the arcuate nucleus DOI Creative Commons
Mara A. Guzmán‐Ruiz,

Natalí N Guerrero Vargas,

Ricardo Jair Ramírez‐Carreto

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 4, 2024

Microglia are highly dynamic cells that have been mainly studied under pathological conditions. The present review discusses the possible implication of microglia as modulators neuronal electrical responses in physiological conditions and hypothesizes how these might modulate hypothalamic circuits health during obesity. Microglial diverse, depending on developmental stage brain region. evidence also suggests activity modulates microglial motility to control excitability. Additionally, we show expression genes associated with neuron-microglia interaction is down-regulated obese mice compared control-fed mice, suggesting an alteration contact-dependent mechanisms sustain arcuate-median eminence function. We discuss microglial-derived signals for excitability neurons homeostasis This emphasizes importance studying interplay between maintain proper circuit It aims elucidate disruptions normal activities can adversely affect health.

Language: Английский

Citations

2
Inflammation-Involved Proteins in Blood Serum of Cataract Patients—A Preliminary Study DOI Creative Commons
Paweł Sutkowy, Hanna Lesiewska‐Junk, Alina Woźniak

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2607 - 2607

Published: Sept. 22, 2023

Approximately 50% of all global blindness is caused by cataract in adults aged ≥50 years. The mechanisms the disease are most arguably related to a redox imbalance and inflammation; therefore, aim study was evaluate processes associated with inflammation patients. Twenty-four patients 22-60 years (62.5% females) participated study, 33 controls 28-60 (66.7% females). Venous blood serum subjects examined for alpha 1-antitrypsin, as well selected lysosomal enzymes adipokines. activities enzymes, activity 1-antitrypsin concentrations c-reactive protein leptin, were similar versus controls. interleukin 6 resistin lower, turn, whereas omentin-1 adiponectin higher. Moreover, revealed existence many linear relationships between parameters, including multiple regression, especially gender-wise. No systemic probably noted tested; nevertheless, deregulation adiponectin, secretion observed.

Language: Английский

Citations

5