The gut microbiome and hypertension

Nature Reviews Nephrology, Год журнала: 2023, Номер 19(3), С. 153 - 167

Опубликована: Янв. 11, 2023

Язык: Английский

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Irritable Bowel Syndrome and the Gut Microbiome: A Comprehensive Review

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(7), С. 2558 - 2558

Опубликована: Март 28, 2023

Irritable Bowel Syndrome (IBS) is a functional disorder of the gastrointestinal tract characterized by abdominal pain and altered bowel habits. It has prevalence 10 to 25% in United States high disease burden, as evidenced reduced quality life, decreased work productivity increased healthcare utilization costs. IBS been associated with several intra-intestinal extra-intestinal conditions, including psychiatric comorbidities. Although pathophysiology not fully elucidated, it involves dysregulation communication between brain gut (brain–gut axis) which alterations intestinal motility, permeability, visceral hypersensitivity microbiota composition. The purpose this article review role plays IBS, understand factors that affect microbiome explore target treatment.

Язык: Английский

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Comparing early life nutritional sources and human milk feeding practices: personalized and dynamic nutrition supports infant gut microbiome development and immune system maturation

Gut Microbes, Год журнала: 2023, Номер 15(1)

Опубликована: Апрель 13, 2023

Exclusive breastfeeding is recommended for the first six months of life, but many infants receive pumped milk, formula, donor human or other nutritional sources during this critical period. Substantive evidence shows early nutrition influences development microbiome and immune system, affecting lifelong health. However, underlying mechanisms are unclear nuances milk feeding rarely considered. This review synthesizes from studies model systems to discuss impact different on co-development gut microbiome, antigen tolerance, immunity. We highlight two key mechanisms: epigenetics so-called "weaning reaction". Collectively, highlights i) fundamental role parents' own fed directly at breast, as a dynamic personalized source that drives developmental programming, ii) deficiencies alternative priority research areas improving these alternatives when direct not possible.

Язык: Английский

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Dynamics of the preterm gut microbiome in health and disease

AJP Gastrointestinal and Liver Physiology, Год журнала: 2021, Номер 320(4), С. G411 - G419

Опубликована: Янв. 13, 2021

Advances in metagenomics have allowed a detailed study of the gut microbiome, and its role human health disease. Infants born prematurely possess fragile microbial ecosystem that is vulnerable to perturbation. Alterations developing microbiome preterm infants are linked life-threatening diseases such as necrotizing enterocolitis (NEC) late-onset sepsis; may impact future risk asthma, atopy, obesity, psychosocial In this mini-review, we summarize recent literature on origins patterns development perinatal period. The host-microbiome-environmental factors portend dysbiotic intestinal associated with NEC sepsis reviewed. Strategies manipulate mitigate dysbiosis, including use probiotics prebiotics will also be discussed. Finally, explore challenges directions research infants.

Язык: Английский

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Maternal microbe-specific modulation of the offspring microbiome and development during pregnancy and lactation

Gut Microbes, Год журнала: 2023, Номер 15(1)

Опубликована: Май 15, 2023

The maternal microbiome is essential for the healthy growth and development of offspring has long-term effects later in life. Recent advances indicate that begins to regulate fetal health during pregnancy. Furthermore, continues affect early microbial colonization via birth breastfeeding. Compelling evidence indicates involved regulation immune brain affects risk related diseases. Modulating by diet probiotic intervention pregnancy breastfeeding could be a promising therapy future. In this review, we summarize discuss current understanding microbiota development, perinatal metabolite transfer, mother-to-infant transmission during/after its association with as well corresponding

Язык: Английский

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Ecological niches and assembly dynamics of diverse microbial consortia in the gastrointestine of goat kids

The ISME Journal, Год журнала: 2024, Номер 18(1)

Опубликована: Янв. 1, 2024

Goats are globally invaluable ruminants that balance food security and environmental impacts, their commensal microbiome residing in the gastrointestinal tract (GIT) is associated with animal health productivity. However, reference genomes functional repertoires of GIT microbes goat kids have not been fully elucidated. Herein, we performed a comprehensive landscape survey using metagenomic sequencing binning, spanning dense sampling regime covering three compartments spatially five developmental ages temporally. We recovered 1002 high-quality metagenome-assembled (termed kid microbial catalog [GKGMC]), 618 which were novel. They encode more than 2.3 million nonredundant proteins, represent variety carbohydrate-degrading enzymes metabolic gene clusters. The GKGMC-enriched taxa, particularly Sodaliphilus, expanded tree life kids. Using this GKGMC, first deciphered prevalence fiber-degrading bacteria for carbohydrate decomposition rumen colon, while ileal microbiota specialized uptake conversion simple sugars. Moreover, microorganisms rapidly assembled after birth, adaptation occurred phases progression. Finally, phytobiotics modified cascades microbiome, underpinned by enrichment Sharpea azabuensis Olsenella spp. implicated lactate formation utilization. This GKGMC provides novel insights into early-life dynamics distinct compartments, offers resources microbiota-related research

Язык: Английский

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Human Breast Milk: The Role of Its Microbiota and Metabolites in Infant Health

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(19), С. 10665 - 10678

Опубликована: Май 1, 2024

This review explores the role of microorganisms and metabolites in human breast milk their impact on neonatal health. Breast serves as both a primary source nutrition for newborns contributes to development maturation digestive, immunological, neurological systems. It has potential reduce risks infections, allergies, asthma. As our understanding properties advances, there is growing interest incorporating its benefits into personalized infant strategies, particularly situations which breastfeeding not an option. Future formula products are expected emulate composition advantages milk, aligning with evolving nutrition. The long-term health implications still under investigation.

Язык: Английский

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Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age

Mucosal Immunology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Prenatal antibiotic exposure, asthma, and the atopic march: A systematic review and meta‐analysis

Allergy, Год журнала: 2022, Номер 77(11), С. 3233 - 3248

Опубликована: Июнь 11, 2022

Abstract Antibiotic use during pregnancy may increase the risk for asthma in children. We performed a meta‐analysis assessing prenatal antibiotic exposure and childhood wheeze or asthma, as well diseases associated with atopic march. A systematic literature search protocol (PROSPERO‐ID: CRD42020191940) was registered searches were completed using Medline, Proquest, Embase, Cochrane central register of controlled trials. Screening inclusion criteria: published English, German, French, Dutch, Arabic, intervention (use any at time point pregnancy), disease (reporting incidence children primary outcome wheeze), exclusion reviews, preclinical data, descriptive studies, yielded 27 studies. Study quality assessed Newcastle–Ottawa Assessment Scale. Quality evidence Grading Recommendations Assessment, Development, Evaluation (GRADE) approach. Our demonstrates that is an increased relative (RR) developing RR 1.51 (95% CI: 1.17–1.94) 1.28 CI 1.22–1.34) childhood. march association revealed also increases eczema/dermatitis 1.06–1.53) allergic rhinitis 1.13 1.02–1.25). One study found food allergy 1.81 1.11–2.95). Maternal development children, involved There high heterogeneity certainty determined to be low quality, highlighting need more high‐quality studies on this topic. These results have importance stewardship throughout period. This work supported by Deutsche Forschungsgemeinschaft Konrad Adenauer Foundation.

Язык: Английский

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Microbiome assembly and maintenance across the lifespan of bumble bee workers

Molecular Ecology, Год журнала: 2022, Номер 32(3), С. 724 - 740

Опубликована: Ноя. 5, 2022

Abstract How a host's microbiome changes over its lifespan can influence development and ageing. As these temporal patterns have only been described in detail for handful of hosts, an important next step is to compare succession more broadly investigate why it varies. Here we characterize the dynamics stability bumble bee worker gut microbiome. Bumble bees simple host‐specific microbiomes, their microbial may health pollination services. We used 16S rRNA gene sequencing, quantitative PCR metagenomics microbiomes Bombus impatiens workers. also sequenced transcriptomes examine host factors that control At community level, assembly highly predictable similar primary observed human gut. However, at strain partitioning bacterial variants among colonies suggests stochastic colonization events those flies nematodes. find strong differences symbiont species, suggesting ecological members persistence. Finally, show both transcriptome—including expression key immunity genes—stabilize, as opposed senesce, with age. suggest social groups such bees, maintenance contribute inclusive fitness, thus remain under selection even old Our findings provide foundation exploring mechanisms functional outcomes succession.

Язык: Английский

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