Proceedings of the Japan Academy Series B,
Год журнала:
2024,
Номер
100(6), С. 335 - 352
Опубликована: Янв. 1, 2024
Recent
studies
have
highlighted
the
impact
of
disrupted
maternal
gut
microbiota
on
colonization
offspring
microbiota,
with
implications
for
developmental
trajectories.
The
extent
to
which
inherit
characteristics
altered
remains
elusive.
In
this
study,
we
employed
a
mouse
model
where
disruption
was
induced
using
non-absorbable
antibiotics.
Systematic
chronological
analyses
dam
fecal
samples,
luminal
content,
and
tissue
samples
revealed
notable
congruence
between
profiles
those
perturbed
highlighting
profound
influence
early-life
microbiota.
Nonetheless,
certain
dominant
bacterial
genera
in
did
not
transfer
offspring,
indicating
taxonomy-dependent
mechanism
inheritance
Our
results
embody
vertical
transmission
dynamics
an
animal
model,
closely
mirrors
its
mother.
Gut,
Год журнала:
2023,
Номер
unknown, С. gutjnl - 330002
Опубликована: Дек. 12, 2023
The
early-life
period
is
one
of
microbiome
establishment
and
immune
maturation.
Early-life
exposures
are
increasingly
being
recognised
to
play
an
important
role
in
IBD
risk.
composition
functions
the
gut
prenatal,
perinatal,
postnatal
may
be
crucial
towards
development
health
or
disease,
including
IBD,
later
life.
We
herein
present
a
comprehensive
summary
interplay
between
factors
perturbations,
their
association
with
risk
IBD.
In
addition,
we
provide
overview
host
external
early
life
that
known
impact
maturation
implicated
Considering
emerging
concept
prevention,
propose
strategies
minimise
maternal
offspring
exposure
potentially
harmful
variables
recommend
protective
measures
during
pregnancy
postpartum
period.
This
holistic
view
signatures
among
mothers
will
help
frame
our
current
understanding
importance
pathogenesis
roadmap
for
preventive
strategies.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 8, 2024
The
infant
gut
microbiota
undergoes
significant
changes
during
early
life,
which
are
essential
for
immune
system
maturation,
nutrient
absorption,
and
metabolic
programming.
Among
the
various
microbial
metabolites,
short-chain
fatty
acids
(SCFAs),
primarily
acetate,
propionate,
butyrate,
produced
through
fermentation
of
dietary
fibers
by
bacteria,
have
emerged
as
critical
modulators
host-microbiota
interactions.
SCFAs
serve
energy
sources
colonic
cells
play
pivotal
roles
in
regulating
responses,
maintaining
barrier
integrity,
influencing
systemic
pathways.
Recent
research
highlights
potential
neuroprotective
effects
pediatric
populations.
Disruptions
composition
SCFA
production
increasingly
associated
with
a
range
health
issues,
including
obesity,
allergic
disorders,
inflammatory
bowel
disease
(IBD),
neurodevelopmental
disorders.
This
review
synthesizes
current
knowledge
on
role
microbiota-derived
health,
emphasizing
their
contributions
from
development
to
neuroprotection.
It
also
underscores
need
further
unravel
precise
mechanisms
influence
develop
targeted
interventions
that
leverage
therapeutic
benefits.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(7), С. 3572 - 3583
Опубликована: Фев. 9, 2024
In
this
study,
we
aimed
to
explore
the
protective
effects
of
Bifidobacterium
in
colitis
mice
and
potential
mechanisms.
Results
showed
that
breve
(B.
breve)
effectively
colonized
intestinal
tract
alleviated
symptoms
by
reducing
disease
activity
index.
Moreover,
B.
mitigated
epithelial
cell
damage,
inhibited
pro-inflammatory
factors,
upregulated
tight
junction
(TJ)-proteins.
Gut
microbiota
metabolome
analysis
found
boosted
bile
acid-regulating
genera
(such
as
Clostridium
sensu
stricto
1),
which
promoted
acid
deconjugation
intestine.
Notably,
cholic
(CA)
was
closely
associated
with
expression
levels
inflammatory
factors
TJ-proteins
(p
<
0.05).
Our
vitro
experiments
further
confirmed
CA
(20.24
±
4.53
pg/mL)
contributed
inhibition
lipopolysaccharide-induced
tumor
necrosis
factor-α
(49.32
5.27
enhanced
(Occludin
Claudin-1)
MUC2.
This
study
suggested
could
be
a
probiotic
candidate
for
use
infant
foods.
Journal of Global Health,
Год журнала:
2024,
Номер
14
Опубликована: Сен. 13, 2024
Microbes
in
the
human
body
are
determinants
of
life-long
health
and
disease.
Microbiome
acquisition
starts
utero
matures
during
early
childhood
through
breastfeeding.
However,
maternal
gut
dysbiosis
affects
maternal-offspring
microbiome
interplay.
Lines
evidence
on
dysbiosis-targeted
interventions
their
effect
inconsistent
inconclusive.
Therefore,
this
study
summarised
studies
to
identify
most
common
microbiota-targeted
intervention
pregnancy
lactation
comprehensively
evaluate
its
effects
offspring
health.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 11, 2024
Resveratrol
(Res),
a
natural
plant
antitoxin
polyphenol,
is
widely
used
in
animal
husbandry
due
to
its
antioxidant
and
anti-inflammatory
properties,
current
research
has
focused
on
humans,
sows,
female
mice.
This
study
aimed
analyze
the
effects
of
dietary
Res
supplementation
ewes
activity,
immune
responses,
hormone
levels,
rumen
microbiota
metabolites
across
various
reproductive
stages
(estrus,
pregnancy,
lactation).
The
maternal
gut
microbiome
is
the
direct
and
important
source
of
early
colonization
development
neonatal
microbiome.
However,
differences
in
unique
shared
features
between
mothers
with
different
physiological
phenotypes
their
newborns
still
lack
exhaustive
investigation.
Here,
using
a
cow-to-calf
model,
comprehensive
investigation
was
conducted
to
elucidate
pattern
characterization
microbial
transfer
from
offspring.
microbiota
rumen
feces
dairy
cows
were
divided
into
two
clusters
via
enterotype
analysis.
distinguished
by
Prevotella
had
better
production
performance,
whereas
no
difference
observed
classified
enterotype.
Furthermore,
through
pairwise
combination
fecal
ruminal
enterotypes,
we
screened
group
excellent
phenotypes.
gastrointestinal
microbiomes
offspring
differed
significantly.
more
for
meconium
than
feces.
Transmission
beneficial
bacteria
mother
observed.
Additionally,
inherits
advantageous
metabolic
functions
rumen.
resistome
rumen,
feces,
consistent,
abundance
calves
showed
an
expanding
trend.
interaction
antibiotic-resistance
genes
mobile
genetic
elements
most
remarkable.
diversity
core
metabolites
stable
not
affected
specific
varied
greatly.
Our
study
demonstrates
taxa,
function,
characteristics
microbiomes,
reveals
potential
vertical
transmission
model.
These
findings
provide
new
insights
transgenerational
Journal of Developmental Origins of Health and Disease,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 1, 2025
Abstract
To
clarify
the
effects
of
kefir
in
critical
periods
development
adult
diseases,
we
study
intake
during
early
life
on
gut
microbiota
and
prevention
colorectal
carcinogenesis
adulthood.
Lactating
Wistar
rats
were
divided
into
three
groups:
control
(C),
lactation
(KL),
puberty
(KP)
groups.
The
C
KP
groups
received
1
mL
water/day;
KL
dams
milk
daily
(10
8
CFU/mL)
lactation.
After
weaning
(postnatal
day
21),
pups
treatment
until
60
days.
At
67
days
old,
was
induced
through
intraperitoneal
injection
1,
2-dimethylhydrazine.
composition
analyzed
by
16S
rRNA
gene
sequencing
DESeq2
(differential
abundance
method),
revealing
significant
differences
bacterial
abundances
between
consumption
periods.
Maternal
strong
anticancer
power,
suppressed
tumors
offspring
reduced
relative
risk
tumor
development.
cecal
samples
group
enriched
with
Lactobacillus
,
Romboutsia
Blautia
.
In
contrast,
animals
Acinetobacter
administration
development,
emphasis
lactation,
affected
microbial
community
structure
to
promote
host
benefits.
Pearson
analysis
indicated
positive
correlation
number
IL-1
levels.
Therefore,
probiotic
fermented
food
may
be
effective
as
chemopreventive
potential
against
colon
especially
period.
