Dilemas contemporáneos Educación Política y Valores,
Год журнала:
2022,
Номер
unknown
Опубликована: Сен. 1, 2022
La
investigación
aporta
elementos
para
una
mayor
vigilancia
sobre
la
Brucelosis
que
es
enfermedad
transmisible
entre
animales
vertebrados
y
humanos,
identificándose
como
zoonosis
reemergente
causada
por
varias
especies
de
Brucella
spp.
Cabe
mencionar,
transmisión
humano
a
no
tan
frecuente,
pero
se
han
informado
transmisiones
congénitas,
sexuales
leche
humana
los
niños.
A
través
revisión
bibliográfica
descriptiva,
en
base
artículos
científicos
relevancia
médica
revisados
las
bases
datos
Scopus,
The
Cochrane,
Web
of
Science
(WoS),
PubMed,
Library
Embase
hasta
enero
2022,
determinó
necesidad
política
pública
salud
preste
atención
este
problema
potencial
real.
Molecular Medicine,
Год журнала:
2022,
Номер
28(1)
Опубликована: Янв. 29, 2022
Abstract
Background
Biofilm
is
a
community
of
bacteria
embedded
in
an
extracellular
matrix,
which
can
colonize
different
human
cells
and
tissues
subvert
the
host
immune
reactions
by
preventing
detection
polarizing
towards
anti-inflammatory
state,
promoting
persistence
biofilm-embedded
host.
Main
body
manuscript
It
now
well
established
that
function
ultimately
mediated
cellular
metabolism.
The
are
stimulated
to
regulate
their
functions
upon
sensing
danger
signals.
Recent
studies
have
determined
often
display
distinct
metabolic
alterations
impair
responses
when
triggered.
Such
reprogramming
its
physiological
implications
cancer
situations.
In
bacterial
infections,
immuno-metabolic
evaluations
primarily
focused
on
macrophages
neutrophils
planktonic
growth
mode.
Conclusion
Based
differences
inflammatory
planktonic-
versus
biofilm-associated
must
also
consider
against
biofilm
infections.
profound
characterization
cell
could
offer
exciting
novel
targets
for
antibiofilm
therapy.
Journal of Medical Virology,
Год журнала:
2022,
Номер
94(10), С. 4611 - 4627
Опубликована: Июнь 11, 2022
The
field
of
immunometabolism
investigates
and
describes
the
effects
metabolic
rewiring
in
immune
cells
throughout
activation
fates
these
cells.
Recently,
it
has
been
appreciated
that
plays
an
essential
role
progression
viral
infections,
cancer,
autoimmune
diseases.
Regarding
COVID-19,
aberrant
response
underlying
diseases
establishes
two
major
respiratory
pathologies,
including
acute
distress
syndrome
(ARDS)
or
pneumonia-induced
lung
injury
(ALI).
Both
innate
adaptive
immunity
(T
cell-based)
were
impaired
course
severe
coronavirus
2
(SARS-CoV-2)
infection.
Current
findings
have
deciphered
macrophages
(innate
cells)
are
involved
inflammatory
seen
COVID-19.
It
demonstrated
system
can
change
reprogramming
some
conditions,
diseases,
infectious
disease,
growing
on
COVID-19
allow
exploration
metabolites
with
immunomodulatory
properties
as
future
therapies
to
combat
this
hyperinflammatory
response.
elucidation
exact
mechanism
reprograming
could
help
apply
more
precise
approaches
initial
diagnosis,
prognosis,
in-hospital
therapy.
This
report
discusses
latest
from
host
immunometabolic
responses.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Июль 25, 2023
Cellular
metabolism
plays
a
central
role
in
the
regulation
of
both
innate
and
adaptive
immunity.
Immune
cells
utilize
metabolic
pathways
to
modulate
cellular
differentiation
or
death.
The
intricate
interplay
between
immune
response
is
critical
for
maintaining
homeostasis
effective
antiviral
activities.
In
recent
years,
immunometabolism
induced
by
viral
infections
has
been
extensively
investigated,
accumulating
evidence
indicated
that
can
be
hijacked
facilitate
replication.
Generally,
virus-induced
changes
lead
reprogramming
metabolites
enzymes
different
(glucose,
lipid,
amino
acid
metabolism).
Metabolic
affects
function
cells,
regulates
expression
molecules
determines
cell
fate.
Therefore,
it
important
explore
effector
with
immunomodulatory
properties,
including
metabolites,
enzymes,
other
immunometabolism-related
as
antivirals.
This
review
summarizes
relevant
advances
field
infections,
providing
novel
insights
development
PLoS ONE,
Год журнала:
2022,
Номер
17(11), С. e0277287 - e0277287
Опубликована: Ноя. 9, 2022
Staphylococcus
epidermis
is
one
of
the
most
frequent
causes
device-associated
infections
due
to
biofilm
formation.
Current
reports
noted
that
subinhibitory
concentrations
antibiotics
induce
production
in
some
bacteria.
Accordingly,
we
evaluated
effect
exposure
different
cloxacillin,
cefazolin,
clindamycin,
and
vancomycin
on
formation
methicillin-resistant
S
.
epidermidis
(MRSE).
Antimicrobial
susceptibility
testing
minimum
inhibitory/bactericidal
concentration
antimicrobial
agents
were
determined.
MRSE
isolates
selected,
their
ability
was
evaluated.
The
vancomycin,
selected
among
common
choices
clinic,
determined
by
microtitre
method.
Besides,
expression
biofilm-associated
genes
icaA
atlE
Reverse-transcription
quantitative
real-time
polymerase
chain
reaction
(RT-qPCR).
patterns
strains
showed
a
high
level
resistance
as
follows:
80%,
53.3%,
33.3%,
26.6%,
for
erythromycin,
trimethoprim-sulfamethoxazole,
tetracycline,
gentamicin,
respectively.
73.3%
Multidrug-resistant
(MDR).
Minimum
inhibitory
(MIC)
bactericidal
(MBC)
values
range
0.5
to512
μg/mL
1
to1024
0.125
to256
to64
4
to>1024
2
to32
findings
clindamycin
strains.
In
particular,
OD
0.09–0.95,
0.05–0.86,
0.06–1
toward
On
other
hand,
did
not
increase
also
demonstrated
sub-MIC
up-regulated
genes.
0.062
1.16
0.078
1.48
folds,
respectively,
0.11
0.8,
0.1
1.3
folds
0.18
0.98,
0.19
1.4
clindamycin.
contrast,
results
These
overall
show
traditional
can
cause
induction
MRSE,
thereby
increasing
survival
persistence
various
surfaces
worsen
condition
comorbid
infections.
Microorganisms,
Год журнала:
2022,
Номер
10(7), С. 1260 - 1260
Опубликована: Июнь 21, 2022
Brucellosis
is
considered
one
of
the
major
zoonoses
worldwide,
constituting
a
critical
livestock
and
human
health
concern
with
huge
socio-economic
burden.
Immunity Inflammation and Disease,
Год журнала:
2021,
Номер
9(4), С. 1209 - 1218
Опубликована: Авг. 27, 2021
Abstract
Introduction
Human
brucellosis
is
a
zoonotic
bacterial
disease
with
up
to
500,000
new
cases
each
year.
The
major
evasion
mechanisms
from
the
host
immune
system
by
Brucella
are
restraint
of
complement
pathway
and
Toll‐like
receptors
signaling
pathways,
interference
efficient
antigen
presentation
CD4‐positive
T
lymphocytes,
selective
subversion
autophagy
inhibition
dendritic
cell
stimulation,
autophagolysosomal
fusion,
macrophage
apoptosis.
Many
molecular
cellular
pathways
contribute
that
microRNAs
have
vital
function
in
immunopathogenesis
this
disease.
In
regard,
these
molecules
apply
for
their
roles
modulating
various
events
like
inflammatory
reactions
defense.
Recently,
case
immunity
human
brucellosis,
it
has
been
shown
play
an
important
role
against
bacteria.
Methods
Results
study,
we
tried
review
defense
infection
highlight
current
knowledge
infected
cells
pathogens.
recent
findings
suggest
regulation
expression
impaired
during
infection,
which
may
progression
or
responses
pathogen.
Conclusions
interplay
between
miRNAs
pathogens
underlying
process
required
comprehensive
examination
unravel
novel
therapeutic
diagnostic
approaches.
