Immunomodulatory biomaterials against bacterial infections: Progress, challenges, and future perspectives

The Innovation, Год журнала: 2023, Номер 4(6), С. 100503 - 100503

Опубликована: Авг. 29, 2023

•Insights into the intricate facets of immune microenvironment hold key to pioneering clinical strategies in combatting bacterial infections.•The design principles for antimicrobial biomaterials vary depending on at different stages infection.•Immunomodulatory display robust efficacy and vaccine attributes animals trials, promising intractable infections. Bacterial infectious diseases are one leading causes death worldwide. Even with use multiple antibiotic treatment strategies, 4.95 million people died from drug-resistant infections 2019. By 2050, number deaths will reach 10 annually. The increasing mortality may be partly due heterogeneity infection microenvironment, such as bacteria, biofilms, persister cells, intracellular small colony variants. In addition, complexity makes direct activity unsatisfactory long-term chronic attributed failing modulate active action cells. Therefore, there is an urgent need effective alternatives treat Accordingly, development immunomodulatory has recently received considerable interest; however, a comprehensive review their research progress lacking. this review, we focus mainly future perspectives used infection. First, describe characteristics acute phases Then, highlight corresponding advantages disadvantages. Moreover, discuss biomaterial-mediated vaccines' potential applications challenges activating innate adaptive memory. This serve reference studies develop next-generation accelerate translation practice.

Язык: Английский

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The emerging role of microbiota-derived short-chain fatty acids in immunometabolism

International Immunopharmacology, Год журнала: 2022, Номер 110, С. 108983 - 108983

Опубликована: Июнь 21, 2022

Язык: Английский

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Metabolomic profiling of bacterial biofilm: trends, challenges, and an emerging antibiofilm target

World Journal of Microbiology and Biotechnology, Год журнала: 2023, Номер 39(8)

Опубликована: Май 31, 2023

Язык: Английский

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Biofilm Inhibition on Medical Devices and Implants Using Carbon Dots: An Updated Review

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(5), С. 2604 - 2619

Опубликована: Апрель 16, 2024

Biofilms are an intricate community of microbes that colonize solid surfaces, communicating via a quorum-sensing mechanism. These microbial aggregates secrete exopolysaccharides facilitating adhesion and conferring resistance to drugs antimicrobial agents. The escalating global concern over biofilm-related infections on medical devices underscores the severe threat human health. Carbon dots (CDs) have emerged as promising substrate combat disrupt biofilm matrices. Their numerous advantages such facile surface functionalization specific properties, position them innovative anti-biofilm Due their minuscule size, CDs can penetrate cells, inhibiting growth cytoplasmic leakage, reactive oxygen species (ROS) generation, genetic material fragmentation. Research has demonstrated efficacy in biofilms formed by key pathogenic bacteria

Язык: Английский

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Coronavirus disease 2019 (COVID‐19) update: From metabolic reprogramming to immunometabolism

Journal of Medical Virology, Год журнала: 2022, Номер 94(10), С. 4611 - 4627

Опубликована: Июнь 11, 2022

The field of immunometabolism investigates and describes the effects metabolic rewiring in immune cells throughout activation fates these cells. Recently, it has been appreciated that plays an essential role progression viral infections, cancer, autoimmune diseases. Regarding COVID-19, aberrant response underlying diseases establishes two major respiratory pathologies, including acute distress syndrome (ARDS) or pneumonia-induced lung injury (ALI). Both innate adaptive immunity (T cell-based) were impaired course severe coronavirus 2 (SARS-CoV-2) infection. Current findings have deciphered macrophages (innate cells) are involved inflammatory seen COVID-19. It demonstrated system can change reprogramming some conditions, diseases, infectious disease, growing on COVID-19 allow exploration metabolites with immunomodulatory properties as future therapies to combat this hyperinflammatory response. elucidation exact mechanism reprograming could help apply more precise approaches initial diagnosis, prognosis, in-hospital therapy. This report discusses latest from host immunometabolic responses.

Язык: Английский

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The emerging role of 27-hydroxycholesterol in cancer development and progression: An update

International Immunopharmacology, Год журнала: 2022, Номер 110, С. 109074 - 109074

Опубликована: Июль 21, 2022

Язык: Английский

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Cellular metabolism hijacked by viruses for immunoevasion: potential antiviral targets

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Июль 25, 2023

Cellular metabolism plays a central role in the regulation of both innate and adaptive immunity. Immune cells utilize metabolic pathways to modulate cellular differentiation or death. The intricate interplay between immune response is critical for maintaining homeostasis effective antiviral activities. In recent years, immunometabolism induced by viral infections has been extensively investigated, accumulating evidence indicated that can be hijacked facilitate replication. Generally, virus-induced changes lead reprogramming metabolites enzymes different (glucose, lipid, amino acid metabolism). Metabolic affects function cells, regulates expression molecules determines cell fate. Therefore, it important explore effector with immunomodulatory properties, including metabolites, enzymes, other immunometabolism-related as antivirals. This review summarizes relevant advances field infections, providing novel insights development

Язык: Английский

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An enzymatic and metal-organic framework system to prevent biofilm infections

Cell Reports Physical Science, Год журнала: 2025, Номер unknown, С. 102468 - 102468

Опубликована: Март 1, 2025

Язык: Английский

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Angioregulatory role of miRNAs and exosomal miRNAs in glioblastoma pathogenesis

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 148, С. 112760 - 112760

Опубликована: Фев. 25, 2022

Glioblastoma (GB) is a highly aggressive cancer of the central nervous system, occurring in brain or spinal cord. Many factors such as angiogenesis are associated with GB development. Angiogenesis procedure by which pre-existing blood vessels create new that play an essential role health and disease, including tumors. Also, one significant thought to be responsible for treatment resistance many tumors, GB. Hence, improved understanding molecular processes underlying will pave way developing potential treatments. Recently, it has been found microRNAs (miRNAs) exosomal miRNAs have crucial inducing inhibiting process A better knowledge miRNA's regulation pathway offers unique mechanistic insight into mechanism tumor-associated neovascularization. Because advancements miRNA characterization delivery methods, can also employed clinical settings biomarkers anti-angiogenic response well therapies targeting tumor angiogenesis. The recent finding insights about miRNAs' angioregulatory provided throughout review. we discuss concept miRNAs-based future.

Язык: Английский

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Emerging implications of bacterial biofilm in cancer biology: Recent updates and major perspectives

Gut Microbes Reports, Год журнала: 2024, Номер 1(1), С. 1 - 20

Опубликована: Май 7, 2024

Recent insights have unveiled exciting opportunities to explore the intricate interplay among bacterial biofilms, tumor cells, and immune system, thus offering new perspectives in cancer biology. The implications of biofilms this context are remarkably multifaceted. Biofilms can promote growth invasiveness by inducing chronic inflammation, remodeling extracellular matrix, modulating response, which promotes development. findings demonstrated involvement distinct bacteria, like Salmonella typhi gall bladder cancer, Helicobacter pylori gastric Fusobacterium nucleatum oral cancer. These investigations indicate higher prevalence these bacteria individuals with as compared those who healthy. Additionally, create display resistance treatments.In review, we highlighted recent advancements pertaining influences biofilm progression potential molecular mechanisms contribute

Язык: Английский

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