Exploring the journey: A comprehensive review of vaccine development against Klebsiella pneumoniae

Microbiological Research, Год журнала: 2024, Номер 287, С. 127837 - 127837

Опубликована: Июль 18, 2024

Язык: Английский

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Hypervirulent and carbapenem-resistant Klebsiella pneumoniae: A global public health threat

Microbiological Research, Год журнала: 2024, Номер 288, С. 127839 - 127839

Опубликована: Авг. 11, 2024

Язык: Английский

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Clinical and microbiological characteristics and prognosis of invasive infection caused by Klebsiella pneumoniae in the community

Annals of Medicine, Год журнала: 2025, Номер 57(1)

Опубликована: Янв. 10, 2025

Background The incidence of invasive infection Klebsiella pneumoniae (Kp) in the community is increasing every year, and high disability mortality rates associated with them pose great challenges clinical practice. This study aimed to explore microbiological characteristics Kp community.

Язык: Английский

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Molecular mechanisms responsible KPC-135-mediated resistance to ceftazidime-avibactam in ST11-K47 hypervirulent Klebsiella pneumoniae

Emerging Microbes & Infections, Год журнала: 2024, Номер 13(1)

Опубликована: Май 27, 2024

Ceftazidime-avibactam resistance attributable to the

Язык: Английский

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Emerging Challenges in Klebsiella pneumoniae: Antimicrobial Resistance and Novel Approach

Microbial Pathogenesis, Год журнала: 2025, Номер unknown, С. 107399 - 107399

Опубликована: Фев. 1, 2025

Язык: Английский

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Computational strategies in Klebsiella pneumoniae vaccine design: navigating the landscape of in silico insights.

Biotechnology Advances, Год журнала: 2024, Номер 76, С. 108437 - 108437

Опубликована: Авг. 30, 2024

Язык: Английский

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Phages adapt to recognize an O-antigen polysaccharide site by mutating the ‘backup’ tail protein ORF59, enabling reinfection of phage-resistant Klebsiella pneumoniae

Emerging Microbes & Infections, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Phages demonstrate remarkable promise as antimicrobial agents against antibiotic-resistant bacteria. However, the emergence of phage-resistant strains poses challenges to their effective application. In this paper, we presented isolation a phage adaptive mutant that demonstrated enhanced and sustained antibacterial efficacy through co-evolution Klebsiella pneumoniae (K. pneumoniae) 111-2 ZX1Δint in vitro. Our experiments revealed successfully completed adsorption phase by binding host surface, specifically targeting capsular polysaccharide (CPS) receptor via primary receptor-binding protein (RBP) ORF60 auxiliary RBP ORF59. Upon exposure predation, mutations genes wbaP, wbaZ or wzc, which encode synthesis CPS, conferred resistance reducing adsorption. response these defense mechanisms, phages have evolved utilize an alternative site located on O-antigen lipopolysaccharide (LPS) mutation backup This evolutionary change enabled reinfect previously strains. Notably, PR2 carrying ORF59 Q777R, capacity infect both wild-type resistant strains, exhibiting prolonged activity wild conclusion, our findings elucidated complex phage-host adsorption-antagonism mechanism characterized mutation-driven alterations recognition. work contributes deeper understanding adaptability highlights potential for combat bacteria vitro approach.

Язык: Английский

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Investigation on Klebsiella pneumoniae in the field of extracellular vesicles

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Abstract Klebsiella pneumoniae (KP), recognized for its pronounced antibiotic resistance, is a prevalent agent of nosocomial infections such as hospital‐acquired pneumonia. The alarming rate serious and associated mortality renders KP significant public health threat. Extracellular vesicles (EVs) are pivotal in KP's physiological pathological mechanisms, facilitating material information transfer mediating interactions between the bacteria host. critical role EVs enhances our understanding pathophysiology, disease progression, strategies infection control. This review emphasizes mechanics resistance instrumental bacterium‐host interplay, proposing promising research focus advancing diagnosis, therapy, prevention.

Язык: Английский

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In-silico and experimental analysis of Klebsiella pneumoniae fimbriae subunits for vaccine development

Vaccine, Год журнала: 2025, Номер 53, С. 127075 - 127075

Опубликована: Апрель 1, 2025

Язык: Английский

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Antibody-based therapy: an alternative for antimicrobial treatment in the post-antibiotic era

Microbiological Research, Год журнала: 2024, Номер 290, С. 127974 - 127974

Опубликована: Ноя. 15, 2024

Язык: Английский

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