Journal of The Electrochemical Society,
Год журнала:
2024,
Номер
171(7), С. 077505 - 077505
Опубликована: Июль 1, 2024
In
the
pharmaceutical
field,
analytical
chemistry
is
evolving
and
one
area
that
experiencing
enthusiasm
design
implementation
of
solid
contact
ion-selective
electrodes.
We
have
developed
two
potentiometric
sensors
for
selective
assay
a
widely
used
drug
diclofenac
sodium.
Diclofenac
sodium
was
targeted
in
its
most
recommended
dosage
forms
(Arthrotec
®
tablets)
presence
misoprostol.
A
cost-effective
copper
printed
circuit
board
as
substrate
has
been
coated
with
PVC
sensing
membrane
to
fabricate
sensor
I.
Hydrophobic
carbon
nanotubes
(CNTs)
modified
through
situ
reduction
pentafluorophenyl
diazonium
using
borohydride.
An
interlayer
CNTs
inserted
transducer
layer
between
Cu
ion-sensing
II
enhance
electrochemical
performance
stability.
The
microfabricated
electrodes
demonstrated
encouraging
outcomes
upon
direct
combination
misoprostol
other
additives
without
sample
preparation
steps.
responses
presented
linear
Nernstian
pattern
range
1.0
×
10
−4
−2
mol
l
−1
slope
−58.2
−58.4
mV/decade
I
II,
consequently.
Finally,
sustainability
technique
assured
advanced
green
metrics.
Journal of Chromatographic Science,
Год журнала:
2023,
Номер
62(9), С. 807 - 814
Опубликована: Июнь 14, 2023
Ophthalmic
pharmaceutical
preparation
containing
antazoline
(ANT)
and
tetryzoline
(TET)
is
prescribed
widely
as
an
over
the
counter
medication
for
allergic
conjunctivitis
treatment.
Development
of
a
selective,
simple
environmentally
friendly
thin-layer
chromatographic
method
established
to
determine
both
ANT
TET
in
their
pure
forms,
formulation
spiked
aqueous
humor
samples.
By
using
silica
gel
plates
means
developing
system
consists
ethyl
acetate:ethanol
(5:5,
by
volume),
studied
drugs
separation
was
achieved,
scanning
carried
out
at
220.0
nm
separated
bands
with
0.2-18.0
μg/band
concentration
range
each
TET.
Standard
addition
technique
application
proposed
validity.
Statistical
comparison
made
between
official
methods
showing
no
significant
difference
concerning
accuracy
precision.
Furthermore,
greenness
profile
assessment
accomplished
four
metric
tools,
namely,
analytical
greenness,
green
procedure
index,
eco-scale
national
environmental
index.
Highlights.
Reviews in Analytical Chemistry,
Год журнала:
2024,
Номер
43(1)
Опубликована: Янв. 1, 2024
Abstract
In
this
work,
a
solid-state
electrochemical
sensor
relying
on
potentiometric
transduction
was
constructed
and
optimized
to
detect
Bosentan
(BOS)
in
its
pharmaceutical
dosage
form
human
plasma.
BOS
is
useful
pulmonary
hypertension
management
as
nonselective
endothelin
receptor
antagonist.
A
printed
circuit
board
has
been
used
substrate
for
microfabricated
Cu
electrodes.
comparison
control
(Cu/ISM)
electrode,
the
potential
signal
drift
enhanced,
response
time
reduced
by
using
multi-walled
carbon
nanotubes
(MWCNTs)
an
ion-to-electron
transducer
layer.
According
IUPAC
requirements,
suggested
sensors
have
electrochemically
characterized,
linear
dynamic
range
(1.0
×
10
−8
1.0
−5
)
M
with
limit
of
detection
6.28
−9
6.12
MWCNT-based
(Cu/CNT-NC/ISM)
(Cu/ISM),
respectively.
The
described
successfully
selectively
determine
plasma
without
any
pre-treatment
steps.
