Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 15, 2025
Replacing
synthetic
phytochemicals
with
natural
plant
extracts
for
metal
nanoparticle
synthesis
enable
cost-effective,
large-scale
production
reduced
environmental
and
health
risks
while
enhancing
biomedical
efficacy.
This
study
presents
the
green
of
silver
nanoparticles
(AgNPs)
using
a
flavonol-enriched
extract
from
male
papaya
flowers
(KQE),
an
underutilized
agricultural
waste.
Using
20%
(v/v)
KQE,
highly
stable,
spherical
KQ-AgNPs
(12.3
±
3.0
nm)
were
synthesized
via
in-situ
generation
free
radicals,
such
as
ortho-quinones,
which
Ag+
ions.
exhibit
superior
antibacterial
activity
against
both
gram-positive
gram-negative
bacteria
compared
to
chemically
AgNPs
(AgNPs-Chem)
KQE
alone.
In
vitro
anticancer
assays
reveal
enhanced
cytotoxicity
breast
carcinoma
cells
(MCF-7)
IC50
21.25
1.14
µg/mL,
significantly
lower
than
AgNPs-Chem
(33.05
3.13
µg/mL),
maintaining
high
biocompatibility
normal
(HEK-293)
greater
169.96
2.3
µg/mL.
highlights
dual
therapeutic
potential
KQ-AgNPs,
emphasizing
their
efficacy
exemplifying
innovative
waste-to-wealth
approach.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 9871 - 9871
Опубликована: Сен. 12, 2024
This
study
presents
the
phytosynthesis
of
silver-based
nanoparticles
using
tomato
flower
waste
extracts
for
first
time
in
literature.
The
determination
total
polyphenolic
and
flavonoid
contents
showed
high
gallic
acid
equivalents
(6436-8802
mg
GAE/kg
dm)
quercetin
(378-633
QE/kg
dm),
respectively,
dependent
on
extraction
method.
By
Ultra
Performance
Liquid
Chromatography
technique,
14
compounds
were
identified
quantified
extracts.
abundant
phenolic
caffeic
(36,902-32,217
mg/kg)
chlorogenic
(1640-1728
mg/kg),
catechin
(292-251
luteolin
(246-108
mg/kg).
Transmission
electron
microscopy
revealed
a
particle
size
range
14-40
nm.
Fourier
Transform
infrared
spectroscopy
X-ray
diffraction
studies
confirmed
silver/silver
oxide
nanoparticles.
These
findings
hold
significant
results
antibacterial
antitumoral
potential
applications
obtained
nanoparticles,
opening
new
areas
research
development
inspiring
further
exploration.
impact
this
field
metallic
nanoparticle
is
substantial,
as
it
introduces
novel
approach
could
lead
to
advancements
field.
Journal of Nanotheranostics,
Год журнала:
2025,
Номер
6(2), С. 9 - 9
Опубликована: Март 23, 2025
Antibiotic
resistance
poses
a
significant
global
health
challenge,
undermining
the
effectiveness
of
conventional
treatments
and
increasing
mortality
rates
worldwide.
Factors
such
as
overuse
misuse
antibiotics
in
healthcare
agriculture,
along
with
poor
infection
control
practices,
have
accelerated
emergence
resistant
bacterial
strains.
The
stagnation
development
new
antibiotics,
compounded
by
economic
biological
challenges,
has
necessitated
alternative
approaches
to
combat
infections.
Nanotechnology
provides
promising
solution
using
nanoparticles
(NPs),
which
bacteria
through
mechanisms
like
membrane
disruption
reactive
oxygen
species
(ROS)
generation.
Metal-based
silver
zinc
oxide
possess
intrinsic
antimicrobial
properties,
while
polymer-
carbon-based
enhance
drug
delivery
biofilm
penetration.
Unlike
operate
multi-mechanistic
pathways,
reducing
likelihood
improving
treatment
efficacy.
This
review
aims
provide
an
updated,
in-depth
look
at
recent
advances
nanoparticle
research
targeting
antibiotic
resistance,
discussing
different
types
nanoparticles,
action,
current
challenges
opportunities.
By
exploring
evolving
role
nanotechnology
addressing
this
crisis,
intends
highlight
potential
for
transform
landscape
infections
inspire
further
into
these
innovative
solutions.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 30, 2025
Abstract
Microbiologically
influenced
corrosion
(MIC)
of
engineering
structures
poses
significant
safety
risks,
particularly
in
environments
where
sulfate‐reducing
bacteria
(SRB)
are
prevalent.
In
this
study,
a
highly
stable
hydrosol
with
strong
antibacterial
properties
is
developed
by
adsorbing
hydrophilic
groups
polymer
chains
onto
the
Cu‐Ag
bimetallic
nanoparticles
(BNPs).
The
synergistic
effects
polyvinylpyrrolidone
(PVP)
and
polyvinyl
alcohol
(PVA)
overcame
incompatibility
between
components
nanomaterials,
enhancing
dispersion
stability
BNP
hydrosol.
results
demonstrates
that
exhibited
potent
activities
at
50
ppm
(w/w),
achieving
approximately
5‐log
reduction
for
sessile
cells
after
21
days
using
retrieved
coupons
from
3‐day
pre‐culture
vials.
led
to
much
cleaner
X80
coupon
surfaces
due
biofilm
inhibition
MIC
mitigation.
weight
loss
measurements
reveals
efficiencies
91%
78%
25
ppm,
respectively.
Additionally,
density
functional
theory
(DFT)
modeling
copper
regulates
silver
ion
release,
action.
While
shows
great
potential,
challenges
still
exist
scaling
its
applications,
especially
marine
other
harsh
environmental
settings.
This
research
provides
promising
platform
developing
sustainable
bacterial
control
strategies,
suppressing
SRB
growth.
