Tissue specific roles of fatty acid oxidation DOI
Danielle M. Smith, Joseph Choi, Michael J. Wolfgang

и другие.

Advances in Biological Regulation, Год журнала: 2024, Номер unknown, С. 101070 - 101070

Опубликована: Дек. 1, 2024

Язык: Английский

EPA and DHA acylcarnitines are less cardiotoxic than are saturated and monounsaturated long‐chain acylcarnitines DOI Creative Commons
Edgars Liepinsh, Baiba Gukalova,

Kristaps Krims-Dāvis

и другие.

BioFactors, Год журнала: 2025, Номер 51(2)

Опубликована: Март 1, 2025

Abstract Elevated levels of fatty acid‐derived long‐chain acylcarnitines are detrimental to cardiac health, primarily because their adverse effects on mitochondrial function and key metabolic pathways in the heart. While trans‐fatty acids considered harmful omega‐3 polyunsaturated (PUFAs) beneficial, specific properties derived from these types not characterized. This study aimed compare saturated palmitoylcarnitine (PC), monounsaturated cis‐oleoylcarnitine (cis‐OC), trans‐elaidoylcarnitine (trans‐EC), eicosapentaenoylcarnitine (EPAC) docosahexaenoylcarnitine (DHAC) heart function, cell viability, functionality, insulin signaling pathways. Saturated acylcarnitines, particularly trans‐EC, significantly reduced contractility at concentrations 8–12 μM, trans‐EC was identified as most cardiotoxic acylcarnitine. Conversely, presence EPAC DHAC perfusion buffer did impair functionality. also drastically H9C2 viability suppressed OXPHOS by up 70% 25 whereas PUFA‐derived caused only a 20%–25% reduction decrease viability. Furthermore, PC, cis‐OC, inhibited Akt phosphorylation, had much weaker effect signaling. In conclusion, exert significant effects, through impairment function. The safe less likely damage mitochondria, cells, than other acylcarnitines. PUFA intake might be safer acid‐containing lipid sources patients with FAODs cardiometabolic diseases.

Язык: Английский

Процитировано

0

Tissue specific roles of fatty acid oxidation DOI
Danielle M. Smith, Joseph Choi, Michael J. Wolfgang

и другие.

Advances in Biological Regulation, Год журнала: 2024, Номер unknown, С. 101070 - 101070

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

1