Advances in Biological Regulation, Год журнала: 2024, Номер unknown, С. 101070 - 101070
Опубликована: Дек. 1, 2024
Язык: Английский
Advances in Biological Regulation, Год журнала: 2024, Номер unknown, С. 101070 - 101070
Опубликована: Дек. 1, 2024
Язык: Английский
BioFactors, Год журнала: 2025, Номер 51(2)
Опубликована: Март 1, 2025
Abstract Elevated levels of fatty acid‐derived long‐chain acylcarnitines are detrimental to cardiac health, primarily because their adverse effects on mitochondrial function and key metabolic pathways in the heart. While trans‐fatty acids considered harmful omega‐3 polyunsaturated (PUFAs) beneficial, specific properties derived from these types not characterized. This study aimed compare saturated palmitoylcarnitine (PC), monounsaturated cis‐oleoylcarnitine (cis‐OC), trans‐elaidoylcarnitine (trans‐EC), eicosapentaenoylcarnitine (EPAC) docosahexaenoylcarnitine (DHAC) heart function, cell viability, functionality, insulin signaling pathways. Saturated acylcarnitines, particularly trans‐EC, significantly reduced contractility at concentrations 8–12 μM, trans‐EC was identified as most cardiotoxic acylcarnitine. Conversely, presence EPAC DHAC perfusion buffer did impair functionality. also drastically H9C2 viability suppressed OXPHOS by up 70% 25 whereas PUFA‐derived caused only a 20%–25% reduction decrease viability. Furthermore, PC, cis‐OC, inhibited Akt phosphorylation, had much weaker effect signaling. In conclusion, exert significant effects, through impairment function. The safe less likely damage mitochondria, cells, than other acylcarnitines. PUFA intake might be safer acid‐containing lipid sources patients with FAODs cardiometabolic diseases.
Язык: Английский
Процитировано
0Advances in Biological Regulation, Год журнала: 2024, Номер unknown, С. 101070 - 101070
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
1