EPA and DHA acylcarnitines are less cardiotoxic than are saturated and monounsaturated long‐chain acylcarnitines

BioFactors, Journal Year: 2025, Volume and Issue: 51(2)

Published: March 1, 2025

Abstract Elevated levels of fatty acid‐derived long‐chain acylcarnitines are detrimental to cardiac health, primarily because their adverse effects on mitochondrial function and key metabolic pathways in the heart. While trans‐fatty acids considered harmful omega‐3 polyunsaturated (PUFAs) beneficial, specific properties derived from these types not characterized. This study aimed compare saturated palmitoylcarnitine (PC), monounsaturated cis‐oleoylcarnitine (cis‐OC), trans‐elaidoylcarnitine (trans‐EC), eicosapentaenoylcarnitine (EPAC) docosahexaenoylcarnitine (DHAC) heart function, cell viability, functionality, insulin signaling pathways. Saturated acylcarnitines, particularly trans‐EC, significantly reduced contractility at concentrations 8–12 μM, trans‐EC was identified as most cardiotoxic acylcarnitine. Conversely, presence EPAC DHAC perfusion buffer did impair functionality. also drastically H9C2 viability suppressed OXPHOS by up 70% 25 whereas PUFA‐derived caused only a 20%–25% reduction decrease viability. Furthermore, PC, cis‐OC, inhibited Akt phosphorylation, had much weaker effect signaling. In conclusion, exert significant effects, through impairment function. The safe less likely damage mitochondria, cells, than other acylcarnitines. PUFA intake might be safer acid‐containing lipid sources patients with FAODs cardiometabolic diseases.

Language: Английский

Tissue specific roles of fatty acid oxidation

Advances in Biological Regulation, Journal Year: 2024, Volume and Issue: unknown, P. 101070 - 101070

Published: Dec. 1, 2024

Language: Английский