Emerging Applications of Nanotechnology in Healthcare and Medicine

Molecules, Год журнала: 2023, Номер 28(18), С. 6624 - 6624

Опубликована: Сен. 14, 2023

Knowing the beneficial aspects of nanomedicine, scientists are trying to harness applications nanotechnology in diagnosis, treatment, and prevention diseases. There also potential uses designing medical tools processes for new generation scientists. The main objective conducting this research review is gather widespread nanomedicine under one heading highlight standard practices field. Comprehensive has been conducted incorporate latest data related medicine therapeutics derived from acknowledged scientific platforms. Nanotechnology used conduct sensitive procedures. showing successful fields diagnostics, disease regenerative medicine, gene therapy, dentistry, oncology, aesthetics industry, drug delivery, therapeutics. A thorough association cooperation between physicians, clinicians, researchers, technologies will bring forward a future where there more calculated, outlined, technically programed field nanomedicine. Advances being made overcome challenges associated with application due pathophysiological basis This highlights multipronged how proving health industry. need minimize health, environmental, ethical concerns linked nanotechnology.

Язык: Английский

---

Ultrasound-mediated nano drug delivery for treating cancer: Fundamental physics to future directions

Journal of Controlled Release, Год журнала: 2023, Номер 355, С. 552 - 578

Опубликована: Фев. 15, 2023

Язык: Английский

---

Improving tumor treatment through intratumoral injection of drug-loaded magnetic nanoparticles and low-intensity ultrasound

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Янв. 16, 2024

Abstract The intratumoral injection of therapeutic agents responsive to external stimuli has gained considerable interest in treating accessible tumors due its biocompatibility and capacity reduce side effects. For the first time, a novel approach is explored investigate feasibility utilizing low-intensity ultrasound combination with drug-loaded magnetic nanoparticles (MNPs) thermal necrosis chemotherapy objective maximizing tumor damage while avoiding harm surrounding healthy tissue. In this study, mathematical framework proposed based on multi-compartment model evaluate effects transducer’s specifications, MNPs size distribution, drug release response microenvironment characteristics. results indicate that higher rate may increase interstitial fluid pressure, it also simultaneously enhances concentration agent. Moreover, by increasing power frequency transducer, acoustic pressure intensity can be enhanced. This, turn, increases impact accumulated MNPs, resulting rise temperature localized heat generation. Results have demonstrated smaller lower generate compared larger primarily sound waves them. It worth noting been observed enhanced diffusion, allowing them effectively spread within tumor. However, their leads rapid elimination from extracellular space into bloodstream. To summarize, study local carrying drugs not only enables but effectiveness inducing tissue necrosis. findings serve as valuable reliable resource for future research field contribute development personalized medicine.

Язык: Английский

---

Metal-based nanoparticle in cancer treatment: lessons learned and challenges

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Июль 11, 2024

Cancer, being one of the deadliest diseases, poses significant challenges despite existence traditional treatment approaches. This has led to a growing demand for innovative pharmaceutical agents that specifically target cancer cells effective treatment. In recent years, use metal nanoparticles (NPs) as promising alternative conventional therapies gained prominence in research. Metal NPs exhibit unique properties hold tremendous potential various applications Studies have demonstrated certain metals possess inherent or acquired anticancer capabilities through their surfaces. These make an attractive focus therapeutic development. this review, we will investigate applicability several distinct classes tumor targeting may include gold, silver, iron oxide, and other with can be exploited purposes. Additionally, provide comprehensive summary risk factors associated application NPs. Understanding addressing these crucial successful clinical translation mitigate any failures NP-based therapies. By exploring identifying factors, review aims contribute advancement strategies. The anticipated outcome is valuable insights pave way targeted utilizing patients.

Язык: Английский

---

Intratumoral implantable drug delivery system for targeted localized chemotherapy in breast cancer

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 94, С. 105519 - 105519

Опубликована: Фев. 28, 2024

Язык: Английский

---

Charge-Switchable nanoparticles to enhance tumor penetration and accumulation

European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2024, Номер 199, С. 114310 - 114310

Опубликована: Май 4, 2024

Nanoparticle-based drug delivery systems hold potential in chemotherapy, but their limited accumulation tumor tissues hinders effective concentration for combating growth. Hence, altering the physicochemical properties of nanoparticles, particularly surface charge, can enhance performance. This study utilized a computational model to explore nanoparticle system capable dynamically adjusting its charge. In model, nanoparticles bloodstream were assigned neutral or positive which, upon reaching microenvironment, switched negative and releasing chemotherapy drugs into extracellular space. Results revealed that circulating with despite having shorter circulation high clearance rate compared counterparts, could accumulate significantly tissue due transvascular rate. After extravasation, neutralized surface-charged tended only near blood microvessels low diffusion rate, resulting substantial released drainage back bloodstream. On other hand, charge tumor's space, reduction nano-bio interactions, able penetrate deeper tumor, increasing bioavailability by reducing volume drained drugs. Furthermore, analysis suggested burst release yields higher than sustained release, however creation dependent on tissue. The study's findings demonstrate this offer valuable insights future research area.

Язык: Английский

---

Programmable intratumoral drug delivery to breast cancer using wireless bioelectronic device with electrochemical actuation

Expert Opinion on Drug Delivery, Год журнала: 2024, Номер 21(3), С. 495 - 511

Опубликована: Фев. 24, 2024

Breast cancer is a global health concern that demands attention. In our contribution to addressing this disease, study focuses on investigating wireless micro-device for intratumoral drug delivery, utilizing electrochemical actuation. Microdevices have emerged as promising approach in field due their ability enable controlled injections various applications.

Язык: Английский

---

Advancing neurological disorders therapies: Organic nanoparticles as a key to blood-brain barrier penetration

International Journal of Pharmaceutics, Год журнала: 2025, Номер 670, С. 125186 - 125186

Опубликована: Янв. 8, 2025

The blood-brain barrier (BBB) plays a vital role in protecting the central nervous system (CNS) by preventing entry of harmful pathogens from bloodstream. However, this also presents significant obstacle when it comes to delivering drugs for treatment neurodegenerative diseases and brain cancer. Recent breakthroughs nanotechnology have paved way creation wide range nanoparticles (NPs) that can serve as carriers diagnosis therapy. Regarding their promising properties, organic NPs potential be used effective drug delivery across BBB based on recent advancements. These remarkable ability penetrate using various mechanisms. This review offers comprehensive examination intricate structure distinct properties BBB, emphasizing its crucial function preserving balance regulating transport ions molecules. disruption conditions such stroke, Alzheimer's disease, Parkinson's disease highlights importance developing creative approaches drugs. Through encapsulation therapeutic molecules precise targeting processes vasculature, NP formulations present hopeful strategy improve BBB. We explore changes pathological investigate factors affect successful into brain. In addition, we most systems associated with shown positive results treating ischemic disorders. opens up new possibilities nanotechnology-based therapies cerebral diseases.

Язык: Английский

---

Inorganic Nanoparticles and Blood-Brain Barrier Modulation: Advancing Targeted Neurological Therapies

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 287, С. 117357 - 117357

Опубликована: Фев. 5, 2025

Язык: Английский

---

Revolutionizing Prostate Cancer Therapy: Artificial intelligence – based Nanocarriers for Precision Diagnosis and Treatment

Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104653 - 104653

Опубликована: Фев. 1, 2025

Язык: Английский

---