Silver doped-silica nanoparticles reinforced poly (ethylene glycol) diacrylate/hyaluronic acid hydrogel dressings for synergistically accelerating bacterial-infected wound healing

Carbohydrate Polymers, Год журнала: 2022, Номер 304, С. 120450 - 120450

Опубликована: Дек. 13, 2022

Язык: Английский

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Biocompatible Cryogel with Good Breathability, Exudate Management, Antibacterial and Immunomodulatory Properties for Infected Diabetic Wound Healing

Advanced Science, Год журнала: 2023, Номер 10(31)

Опубликована: Сен. 4, 2023

Due to the complex microenvironment and healing process of diabetic wounds, developing wound dressing with good biocompatibility, mechanical stability, breathability, exudate management, antibacterial ability, immunomodulatory property is highly desired but remains a huge challenge. Herein, multifunctional cryogel designed prepared bio-friendly bacterial cellulose, gelatin, dopamine under condition sodium periodate oxidation. Bacterial cellulose can enhance stability by improving skeleton supporting effect crosslinking degree. The shows outstanding breathability management capability thanks interpenetrated porous structures. I

Язык: Английский

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Thou shall not heal: Overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 203, С. 115120 - 115120

Опубликована: Окт. 25, 2023

Diabetic foot ulcers (DFUs) are a devastating complication for diabetic patients that have debilitating effects and can ultimately lead to limb amputation. Healthy wounds progress through the phases of healing leading tissue regeneration restoration barrier function skin. In contrast, in dysregulation these leads chronic, non-healing wounds. particular, unresolved inflammation DFU microenvironment has been identified as key facet chronic hyperglyceamic patients, DFUs fail beyond inflammatory phase towards resolution. Thus, control over modulation response is promising therapeutic avenue treatment. This review discusses current state-of-the art regarding microenvironment, with specific focus on development biomaterials-based delivery strategies their cargos direct microenvironment.

Язык: Английский

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Recent advances in biomimetic hemostatic materials

Materials Today Bio, Год журнала: 2023, Номер 19, С. 100592 - 100592

Опубликована: Фев. 24, 2023

Although the past decade has witnessed unprecedented medical advances, achieving rapid and effective hemostasis remains challenging. Uncontrolled bleeding wound infections continue to plague healthcare providers, increasing risk of death. Various types hemostatic materials are nowadays used during clinical practice but have many limitations, including poor biocompatibility, toxicity biodegradability. Recently, there been a burgeoning interest in organisms that stick objects or produce sticky substances. Indeed, applying biological adhesion properties an interesting approach. This paper reviews behavior, bionics, mechanisms related hemostasis. Furthermore, this covers benefits, challenges prospects biomimetic materials.

Язык: Английский

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Injectable hyperbranched PEG crosslinked hyaluronan hydrogel microparticles containing mir-99a-3p modified subcutaneous ADSCs-derived exosomes was beneficial for long-term treatment of osteoarthritis

Materials Today Bio, Год журнала: 2023, Номер 23, С. 100813 - 100813

Опубликована: Сен. 28, 2023

Exosomes (Exos) secreted by adipose-derived stem cells (ADSCs) have shown potential in alleviating osteoarthritis (OA). Previous studies indicated that infrapatellar fat pad (IPFP) derived (IPFSCs) may be more suitable for the treatment of OA than subcutaneous adipose tissue (ScAT) (ScASCs). However, it remains unclear which type Exos offers superior therapeutic benefit OA. This study first compared differences between from IPFP (ExosIPFP) and ScAT (ExosScAT) treatment. Results suggested ExosIPFP significantly inhibit degradation cartilage extracellular matrix (ECM) ExosScAT, following this, microRNA (miRNA) expression two types using small RNA sequencing were performed. Subsequently, miR-99 b-3p was chosen over-expressed ExosScAT (ExosScAT−99b−3p), both vivo vitro experiments demonstrated its efficacy inhibiting ADAMTS4, promoting repair ECM Finally, microfluidic technology performed to fabricate a hyaluronan-based hydrogel microparticles (HMPs) encapsulating (HMPs@exos), injectability, sustained release long-term effect on validated. In summary, these results suggest regulates targeting upregulation would enable them exhibit comparable or even effectiveness treatment, making promising approach Considering abundant resources limited availability IPFP, harvested through liposuction could genetically engineered yield Furthermore, encapsulation HMPs provides an injectable local drug system, potentially enhance hold as future strategies.

Язык: Английский

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Recent Applications of Melanin-like Nanoparticles as Antioxidant Agents

Antioxidants, Год журнала: 2023, Номер 12(4), С. 863 - 863

Опубликована: Апрель 2, 2023

Nanosized antioxidants are highly advantageous in terms of versatility and pharmacokinetics, with respect to conventional molecular ones. Melanin-like materials, artificial species inspired by natural melanin, combine recognized antioxidant (AOX) activity a unique preparation modification. Due this documented biocompatibility, melanin has been incorporated into variety nanoparticles (NP) order give new platforms for nanomedicine enhanced AOX activity. In review article, we first discuss the chemical mechanisms behind materials context inhibition radical chain reaction responsible peroxidation biomolecules. We also focus briefly on properties melanin-like NP, considering effect parameters such as size, methods surface functionalization them. Then, consider most recent relevant applications NPs that able counteract ferroptosis be involved treatment important diseases affect, e.g., cardiovascular nervous systems, well kidneys, liver articulations. A specific section will dedicated cancer treatment, since role is still very debated. Finally, propose future strategies development better understanding materials. particular, composition structure these debated, they present high level variability. Thus, mechanism interaction nanostructures different radicals reactive would design more effective nano-agents.

Язык: Английский

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Nanofibrous Scaffolds for Diabetic Wound Healing

Pharmaceutics, Год журнала: 2023, Номер 15(3), С. 986 - 986

Опубликована: Март 19, 2023

Chronic wounds are one of the secondary health complications that develop in individuals who have poorly managed diabetes mellitus. This is often associated with delays wound healing process, resulting from long-term uncontrolled blood glucose levels. As such, an appropriate therapeutic approach would be maintaining concentration within normal ranges, but this can quite challenging to achieve. Consequently, diabetic ulcers usually require special medical care prevent such as sepsis, amputation, and deformities, which these patients. Although several conventional dressings, hydrogels, gauze, films, foams, employed treatment chronic wounds, nanofibrous scaffolds gained attention researchers because their flexibility, ability load a variety bioactive compounds single entities or combinations, large surface area volume ratio, provides biomimetic environment for cell proliferation relative dressings. Here, we present current trends on versatility novel platforms incorporation agents suitable enhancement healing.

Язык: Английский

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Mussel bioinspired, silver-coated and insulin-loaded mesoporous polydopamine nanoparticles reinforced hyaluronate-based fibrous hydrogel for potential diabetic wound healing

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 247, С. 125738 - 125738

Опубликована: Июль 8, 2023

Язык: Английский

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Advances in Zebrafish for Diabetes Mellitus with Wound Model

Bioengineering, Год журнала: 2023, Номер 10(3), С. 330 - 330

Опубликована: Март 6, 2023

Diabetic foot ulcers cause great suffering and are costly for the healthcare system. Normal wound healing involves hemostasis, inflammation, proliferation, remodeling. However, negative factors associated with diabetes, such as bacterial biofilms, persistent impaired angiogenesis, inhibited cell pathological scarring, greatly interfere smooth progress of entire process. It is this that leads to diabetic even amputations. Therefore, drug screening challenging due complexity damaged mechanisms. The establishment a scientific reasonable animal experimental model contributes significantly in-depth research pathology, prevention, diagnosis, treatment. In addition low cost transparency embryo (for imaging transgene applications), zebrafish have discrete process separate study each stage, resulting in their potential ideal future. review, we examine reasons behind delayed wounds, systematically review various studies using by different induction methods, well summarize challenges improvement strategies which provide references establishing more model.

Язык: Английский

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Examining the wound healing potential of curcumin-infused electrospun nanofibers from polyglutamic acid and gum arabic

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 267, С. 131237 - 131237

Опубликована: Март 28, 2024

Язык: Английский

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