Small Structures,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
The
clinical
treatment
of
central
nervous
system
(CNS)
injuries
presents
significant
challenges
due
to
the
inflammatory
microenvironment
(IME)
induced
by
CNS
injury,
which
inhibits
spontaneous
neuronal
regeneration.
Biomimetic
biomaterial‐based
IMEs
for
repair,
facilitate
reconstruction
neural
regeneration
circuits,
show
promise.
In
this
study,
development
novel
bioactive
peptide
nanofibers
(PNFs)/chitosan
(CS)/VD11
(VDELWPPWLPC)
hydrogels
(named
as
PCV)
is
reported,
created
reinforcing
composite
PNFs/CS
with
a
frog‐derived
neuroregenerative
(VD11).
exhibit
3D
porous
structure,
high
thermosensitivity,
good
injectability,
and
enhanced
neurotrophic
properties,
making
them
promising
candidates
repair.
in
vitro
tests
indicate
that
PCV
can
promote
proliferation,
migration,
differentiation
stem
cells
into
neurons,
well
guide
axonal
growth.
Additionally,
they
help
mitigate
responses
reducing
macrophage
activation
astrocyte
while
promoting
neovascularization.
vivo
animal
experimentsdemonstrate
enhance
blood
supply
damaged
area
migration
colonization
endogenous
support
Furthermore,
reduce
immune
limit
excessive
significantly
improving
motor
function
recovery
rats
spinal
cord
injuries.
these
findings,
it
suggested
provide
strategy
treating
regulating
IME.
Macromolecular Bioscience,
Год журнала:
2024,
Номер
24(6)
Опубликована: Март 28, 2024
Abstract
Spinal
cord
injury,
traumatic
brain
and
neurosurgery
procedures
usually
lead
to
neural
tissue
damage.
Self‐assembled
peptide
(SAP)
hydrogels,
a
type
of
innovative
hierarchical
nanofiber‐forming
sequences
serving
as
hydrogelators,
have
emerged
promising
solution
for
repairing
defects
promoting
regeneration.
SAPs
possess
numerous
features,
such
adaptable
morphologies,
biocompatibility,
injectability,
tunable
mechanical
stability,
mimicking
the
native
extracellular
matrix.
This
review
explores
capacity
cell
regeneration
examines
critical
aspects
in
neuroregeneration,
including
their
biochemical
composition,
topology,
behavior,
conductivity,
degradability.
Additionally,
it
delves
into
latest
strategies
involving
central
or
peripheral
engineering.
Finally,
prospects
SAP
hydrogel
design
development
realm
neuroregeneration
are
discussed.
Materials Today Advances,
Год журнала:
2024,
Номер
22, С. 100490 - 100490
Опубликована: Апрель 10, 2024
Brain
diseases,
encompassing
neurodegenerative
disorders,
strokes,
and
brain
tumors,
represent
significant
medical
conditions
with
profound
implications
for
human
health.
The
blood-brain
barrier
(BBB)
the
blood-cerebral-spinal
cord
(BCSFB)
limited
drug
penetration,
poor
targeting,
proliferation
easy
death
of
mature
neuronal
cells
greatly
impair
regeneration
central
nervous
system
after
injury,
thus
call
more
advanced
therapeutic
strategies
in
clinic.
Biomedical
hydrogel
research
presents
a
potentially
novel
approach
management
disorders.
Hydrogels
are
extremely
biocompatible
scaffolding
materials
that
can
be
loaded
variety
drugs
achieving
effective
treatments
disorders
customized
different
mechanical
properties
to
match
target
organ
or
modulate
its
environment.
This
article
offers
an
overview
recent
progress,
challenges,
prospective
developments
utilization
hydrogels
treating
objective
accentuating
their
potential
as
early
intervention
preclinical
phase.
unique
mechanisms
release
examined
detail:
extended-release
medications,
environmental
drugs,
material's
own
activity.
An
understanding
these
helps
make
delivery
systems
possible.
Small Structures,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
The
clinical
treatment
of
central
nervous
system
(CNS)
injuries
presents
significant
challenges
due
to
the
inflammatory
microenvironment
(IME)
induced
by
CNS
injury,
which
inhibits
spontaneous
neuronal
regeneration.
Biomimetic
biomaterial‐based
IMEs
for
repair,
facilitate
reconstruction
neural
regeneration
circuits,
show
promise.
In
this
study,
development
novel
bioactive
peptide
nanofibers
(PNFs)/chitosan
(CS)/VD11
(VDELWPPWLPC)
hydrogels
(named
as
PCV)
is
reported,
created
reinforcing
composite
PNFs/CS
with
a
frog‐derived
neuroregenerative
(VD11).
exhibit
3D
porous
structure,
high
thermosensitivity,
good
injectability,
and
enhanced
neurotrophic
properties,
making
them
promising
candidates
repair.
in
vitro
tests
indicate
that
PCV
can
promote
proliferation,
migration,
differentiation
stem
cells
into
neurons,
well
guide
axonal
growth.
Additionally,
they
help
mitigate
responses
reducing
macrophage
activation
astrocyte
while
promoting
neovascularization.
vivo
animal
experimentsdemonstrate
enhance
blood
supply
damaged
area
migration
colonization
endogenous
support
Furthermore,
reduce
immune
limit
excessive
significantly
improving
motor
function
recovery
rats
spinal
cord
injuries.
these
findings,
it
suggested
provide
strategy
treating
regulating
IME.
