Meteorological Influence as an Exacerbating Factor in Knee Osteoarthritis: A Prospective Longitudinal Study DOI Creative Commons

Anping Shen,

Qinguang Xu,

Jiang Ding

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Март 27, 2024

Abstract Background Osteoarthritis (OA) is a primary cause of disability among the elderly, and its pathogenesis unclear. This study explores correlations different meteorological factors to characteristics outcomes knee osteoarthritis (KOA) patients through 2-year follow-up. Methods The enrolled 70 participants with KOA from Shanghai, China conducted follow-up assessment 2 years later. Assessment parameters included pain score, bone marrow abnormality (BMA) levels proinflammatory cytokine interleukin-1β (IL-1β) IL-6. Additionally, data on temperature, wind speed, relative humidity were collected local stations. At baseline, discretized into binary variables using their respective median values. analysis associations between these scores, BMA cytokines Mann-Whitney U test. Longitudinally, mentioned indicators determined multivariate linear regression models. Results average age individuals 60.6 old. In low temperature group had higher WOMAC scores (p = 0.022), increased IL-1β < 0.001) IL-6 0.047) compared those in high group. longitudinal analysis, there notable fluctuations alterations (β=-0.916, p 0.001), (β=-0.859, (β=-0.577, 0.006). Conclusion These findings provide evidence that has significant impact inflammatory KOA. Conversely, speed do not exhibit such effects.

Язык: Английский

A Bioactive Injectable Hydrogel Regulates Tumor Metastasis and Wound Healing for Melanoma via NIR‐Light Triggered Hyperthermia DOI Creative Commons
Xueyi Liu,

Meifang Shen,

Tiejun Bing

и другие.

Advanced Science, Год журнала: 2024, Номер 11(26)

Опубликована: Май 5, 2024

Abstract Surgical resection remains the mainstream treatment for malignant melanoma. However, challenges in wound healing and residual tumor metastasis pose significant hurdles, resulting high recurrence rates patients. Herein, a bioactive injectable hydrogel (BG‐Mn gel ) formed by crosslinking sodium alginate (SA) with manganese‐doped glass (BG‐Mn) is developed as versatile platform anti‐tumor immunotherapy postoperative The incorporation of Mn 2+ within (BG) can activate cGAS‐STING immune pathway to elicit robust response cancer immunotherapy. Furthermore, doping BG endows system excellent photothermal properties, hence facilitating STING activation reversing immune‐suppressive microenvironment. exhibits favorable angiogenic capacity tissue regenerative potential, promotes cell migration vitro. When combining BG‐Mn anti‐PD‐1 antibody (α‐PD‐1) melanoma, it shows enhanced long‐term memory response. Remarkably, upregulate expression genes related blood vessel formation promote skin regeneration when treating full‐thickness wounds. Overall, Gel serves an effective adjuvant therapy regulate

Язык: Английский

Процитировано

20
Photoactivated Hydrogel Therapeutic System with MXene‐Based Nanoarchitectonics Potentiates Endogenous Bone Repair Through Reshaping the Osteo‐Vascularization Network DOI
Minhao Wu, Yufeng Zhang, Yanfang Zhao

и другие.

Small, Год журнала: 2024, Номер unknown

Опубликована: Окт. 8, 2024

Abstract The repair and reconstruction of large‐scale bone defects face enormous challenges because the failure to reconstruct osteo‐vascularization network. Herein, a near‐infrared (NIR) light‐responsive hydrogel system is reported achieve programmed tissue regeneration through synergetic effects on‐demand drug delivery mild heat stimulation. spatiotemporal (HG/MPa) composed polydopamine‐coated Ti 3 C 2 T x MXene (MP) nanosheets decorated with acidic fibroblast growth factor (aFGF, potent angiogenic drug) hydroxypropyl chitosan/gelatin (HG) developed orchestrate network boost regeneration. Upon exposure NIR light irradiation, engineered HG/MPa can initial complete release aFGF induce rapid angiogenesis provide sufficient blood supply, maximizing its biofunction in defect area. This integrated demonstrated good therapeutic efficacy promoting cell adhesion, proliferation, migration, angiogenesis, osteogenic differentiation periodic irradiation. In vivo, animal experiments further revealed that spatiotemporalized platform synergized photothermal treatment significantly accelerated critical‐sized healing by increasing density, recruiting endogenous stem cells, facilitating production osteogenesis/angiogenesis‐related factors. Overall, smart‐responsive could enhance

Язык: Английский

Процитировано

16
Photothermal switch by gallic acid-calcium grafts synthesized by coordination chemistry for sequential treatment of bone tumor and regeneration DOI Creative Commons
Xiaodong Hou, Lei Zhang, Yixing Chen

и другие.

Biomaterials, Год журнала: 2024, Номер 312, С. 122724 - 122724

Опубликована: Июль 30, 2024

The residual bone tumor and defects which is caused by surgical therapy of a major important problem in clinicals. And the sequential treatment for irradiating repairing has wildly prospects. In this study, we developed general modification strategy gallic acid (GA)-assisted coordination chemistry to prepare black calcium-based materials, combines photothermal defects. GA endows materials remarkable properties. Under near-infrared (NIR) irradiation with different power densities, GA-modified matrix (GBM) did not merely display an excellent performance eliminating high temperature, but showed facile effect mild-heat stimulation accelerate regeneration. GBM can efficiently regulate microenvironments regeneration spatial-temporal manner, including inflammation/immune response, vascularization osteogenic differentiation. Meanwhile, integrin/PI3K/Akt signaling pathway marrow mesenchymal stem cells (BMSCs) was revealed be involved osteogenesis induced stimulation. outcome study only provides serial new multifunctional biomaterials, also demonstrates designing novel blacked biomaterials great potential clinical use.

Язык: Английский

Процитировано

10
Synergistic combinational photothermal therapy-based approaches for cancer treatment DOI Creative Commons
Gaurisha Alias Resha Ramnath Naik, Ashutosh Gupta, Deepanjan Datta

и другие.

FlatChem, Год журнала: 2025, Номер unknown, С. 100834 - 100834

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
A Self-Powered Casein Hydrogel E-Dressing with Synergistic Photothermal Therapy, Electrical Stimulation, and Antibacterial Effects for Chronic Wound Management DOI
Yuhang Xu, Xiaoyu Xu, Yuan Zhao

и другие.

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
Green synthesis-inspired antibacterial, antioxidant and adhesive hydrogels with ultra-fast gelation and hemostasis for promoting infected skin wound healing DOI
Mengyu Yang,

Hua Zhao,

Yachao Yu

и другие.

Acta Biomaterialia, Год журнала: 2024, Номер 184, С. 156 - 170

Опубликована: Июнь 17, 2024

Язык: Английский

Процитировано

9
Hydrogel Coatings of Implants for Pathological Bone Repair DOI

Mengqing Li,

Youzhun Fan,

Maofei Ran

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Май 25, 2024

Hydrogels are well-suited for biomedical applications due to their numerous advantages, such as excellent bioactivity, versatile physical and chemical properties, effective drug delivery capabilities. Recently, hydrogel coatings have developed functionalize bone implants which biologically inert cannot withstand the complex tissue repair microenvironment. These shown promise in addressing unique pressing medical needs. This review begins with major functionalized performance interfacial bonding strategy of coatings, a focus on novel external field response properties hydrogel. Recent advances fabrication strategies use treatment pathologic regeneration highlighted. Finally, challenges emerging trends evolution application physiological environment-responsive electric field-responsive discussed.

Язык: Английский

Процитировано

8
ZIF-8-Modified Black Phosphorus Nanosheets Incorporated into Injectable Dual-Component Hydrogels for Enhanced Photothermal Antibacterial and Osteogenic Activities DOI
Quan Li, Ruijie Wang,

Jinfang Xue

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(25), С. 32058 - 32077

Опубликована: Июнь 14, 2024

The development of growth factor-free biomaterials for bone tissue regeneration with anti-infection and anti-inflammatory activities remains challenging. Black phosphorus nanosheets (BPNs), distinctive attributes, including photothermal conversion calcium ion chelation, offer potential use in engineering infection prevention. However, BPNs are prone to oxidation degradation aqueous environments, methods stabilize long-term repair remain insufficient. Herein, zeolitic imidazolate framework-8 (ZIF-8) was used via situ crystallization onto the surface (BP@ZIF-8 nanocomposite). A novel injectable dual-component hydrogel comprising gelatin methacryloyl (GelMA) methacrylate-modified hyaluronic acid (HAMA) as a BP@ZIF-8 nanocomposite carrier (GelMA/HAMA/BP@ZIF-8). could effectively protect internal from enhance performance both vitro vivo settings. GelMA/HAMA/BP@ZIF-8 exhibited outstanding conversion, mechanical strength, biodegradability, well excellent antibacterial activity against Staphylococcus aureus Escherichia coli an rat model. also provided microenvironment conducive osteogenic differentiation, promoting transformation M2 macrophages inhibiting inflammatory responses. Furthermore, promoted had synergistic effect near-infrared irradiation skull-defect Transcriptome sequencing analysis revealed that PI3K-AKT- calcium-signaling pathways may be involved differentiation induced by GH-BZ hydrogel. This study presents innovative, multifaceted solution challenges effects, providing insights into design smart dual therapeutic capabilities.

Язык: Английский

Процитировано

6
Remote actuation and on-demand activation of biomaterials pre-incorporated with physical cues for bone repair DOI Creative Commons

Xueping Kong,

Tianyi Zheng,

Zhaoyi Wang

и другие.

Theranostics, Год журнала: 2024, Номер 14(11), С. 4438 - 4461

Опубликована: Янв. 1, 2024

The high incidence of bone defect-related diseases caused by trauma, infection, and tumor resection has greatly stimulated research in the field regeneration. Generally, healing is a long complicated process wherein manipulating biological activity interventional scaffolds to support long-term regeneration significant for treating bone-related diseases. It been reported that some physical cues can act as growth factor substitutes promote osteogenesis through continuous activation endogenous signaling pathways. This review focuses on latest progress repair remote actuation on-demand biomaterials pre-incorporated with (heat, electricity, magnetism). As an alternative method treat defects, show many advantages, including effectiveness, noninvasiveness, manipulation. First, we introduce impact different potential internal regulatory mechanisms. Subsequently, mediate various their respective characteristics are summarized. Additionally, challenges discussed, aiming provide new insights suggestions developing intelligent defects clinical translation.

Язык: Английский

Процитировано

5
A multifunctional biosensor for selective identification, sensitive detection and efficient photothermal sterilization of Salmonella typhimurium and Staphylococcus aureus DOI

Huasong Dai,

Yingyue Zhang,

Wenshi Zhao

и другие.

Analytica Chimica Acta, Год журнала: 2024, Номер 1338, С. 343589 - 343589

Опубликована: Дек. 25, 2024

Язык: Английский

Процитировано

5