
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Март 27, 2024
Язык: Английский
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Март 27, 2024
Язык: Английский
Advanced Science, Год журнала: 2024, Номер 11(26)
Опубликована: Май 5, 2024
Abstract Surgical resection remains the mainstream treatment for malignant melanoma. However, challenges in wound healing and residual tumor metastasis pose significant hurdles, resulting high recurrence rates patients. Herein, a bioactive injectable hydrogel (BG‐Mn gel ) formed by crosslinking sodium alginate (SA) with manganese‐doped glass (BG‐Mn) is developed as versatile platform anti‐tumor immunotherapy postoperative The incorporation of Mn 2+ within (BG) can activate cGAS‐STING immune pathway to elicit robust response cancer immunotherapy. Furthermore, doping BG endows system excellent photothermal properties, hence facilitating STING activation reversing immune‐suppressive microenvironment. exhibits favorable angiogenic capacity tissue regenerative potential, promotes cell migration vitro. When combining BG‐Mn anti‐PD‐1 antibody (α‐PD‐1) melanoma, it shows enhanced long‐term memory response. Remarkably, upregulate expression genes related blood vessel formation promote skin regeneration when treating full‐thickness wounds. Overall, Gel serves an effective adjuvant therapy regulate
Язык: Английский
Процитировано
20Small, Год журнала: 2024, Номер unknown
Опубликована: Окт. 8, 2024
Abstract The repair and reconstruction of large‐scale bone defects face enormous challenges because the failure to reconstruct osteo‐vascularization network. Herein, a near‐infrared (NIR) light‐responsive hydrogel system is reported achieve programmed tissue regeneration through synergetic effects on‐demand drug delivery mild heat stimulation. spatiotemporal (HG/MPa) composed polydopamine‐coated Ti 3 C 2 T x MXene (MP) nanosheets decorated with acidic fibroblast growth factor (aFGF, potent angiogenic drug) hydroxypropyl chitosan/gelatin (HG) developed orchestrate network boost regeneration. Upon exposure NIR light irradiation, engineered HG/MPa can initial complete release aFGF induce rapid angiogenesis provide sufficient blood supply, maximizing its biofunction in defect area. This integrated demonstrated good therapeutic efficacy promoting cell adhesion, proliferation, migration, angiogenesis, osteogenic differentiation periodic irradiation. In vivo, animal experiments further revealed that spatiotemporalized platform synergized photothermal treatment significantly accelerated critical‐sized healing by increasing density, recruiting endogenous stem cells, facilitating production osteogenesis/angiogenesis‐related factors. Overall, smart‐responsive could enhance
Язык: Английский
Процитировано
16Biomaterials, Год журнала: 2024, Номер 312, С. 122724 - 122724
Опубликована: Июль 30, 2024
The residual bone tumor and defects which is caused by surgical therapy of a major important problem in clinicals. And the sequential treatment for irradiating repairing has wildly prospects. In this study, we developed general modification strategy gallic acid (GA)-assisted coordination chemistry to prepare black calcium-based materials, combines photothermal defects. GA endows materials remarkable properties. Under near-infrared (NIR) irradiation with different power densities, GA-modified matrix (GBM) did not merely display an excellent performance eliminating high temperature, but showed facile effect mild-heat stimulation accelerate regeneration. GBM can efficiently regulate microenvironments regeneration spatial-temporal manner, including inflammation/immune response, vascularization osteogenic differentiation. Meanwhile, integrin/PI3K/Akt signaling pathway marrow mesenchymal stem cells (BMSCs) was revealed be involved osteogenesis induced stimulation. outcome study only provides serial new multifunctional biomaterials, also demonstrates designing novel blacked biomaterials great potential clinical use.
Язык: Английский
Процитировано
10FlatChem, Год журнала: 2025, Номер unknown, С. 100834 - 100834
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1Acta Biomaterialia, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1Acta Biomaterialia, Год журнала: 2024, Номер 184, С. 156 - 170
Опубликована: Июнь 17, 2024
Язык: Английский
Процитировано
9Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Май 25, 2024
Hydrogels are well-suited for biomedical applications due to their numerous advantages, such as excellent bioactivity, versatile physical and chemical properties, effective drug delivery capabilities. Recently, hydrogel coatings have developed functionalize bone implants which biologically inert cannot withstand the complex tissue repair microenvironment. These shown promise in addressing unique pressing medical needs. This review begins with major functionalized performance interfacial bonding strategy of coatings, a focus on novel external field response properties hydrogel. Recent advances fabrication strategies use treatment pathologic regeneration highlighted. Finally, challenges emerging trends evolution application physiological environment-responsive electric field-responsive discussed.
Язык: Английский
Процитировано
8ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(25), С. 32058 - 32077
Опубликована: Июнь 14, 2024
The development of growth factor-free biomaterials for bone tissue regeneration with anti-infection and anti-inflammatory activities remains challenging. Black phosphorus nanosheets (BPNs), distinctive attributes, including photothermal conversion calcium ion chelation, offer potential use in engineering infection prevention. However, BPNs are prone to oxidation degradation aqueous environments, methods stabilize long-term repair remain insufficient. Herein, zeolitic imidazolate framework-8 (ZIF-8) was used via situ crystallization onto the surface (BP@ZIF-8 nanocomposite). A novel injectable dual-component hydrogel comprising gelatin methacryloyl (GelMA) methacrylate-modified hyaluronic acid (HAMA) as a BP@ZIF-8 nanocomposite carrier (GelMA/HAMA/BP@ZIF-8). could effectively protect internal from enhance performance both vitro vivo settings. GelMA/HAMA/BP@ZIF-8 exhibited outstanding conversion, mechanical strength, biodegradability, well excellent antibacterial activity against Staphylococcus aureus Escherichia coli an rat model. also provided microenvironment conducive osteogenic differentiation, promoting transformation M2 macrophages inhibiting inflammatory responses. Furthermore, promoted had synergistic effect near-infrared irradiation skull-defect Transcriptome sequencing analysis revealed that PI3K-AKT- calcium-signaling pathways may be involved differentiation induced by GH-BZ hydrogel. This study presents innovative, multifaceted solution challenges effects, providing insights into design smart dual therapeutic capabilities.
Язык: Английский
Процитировано
6Theranostics, Год журнала: 2024, Номер 14(11), С. 4438 - 4461
Опубликована: Янв. 1, 2024
The high incidence of bone defect-related diseases caused by trauma, infection, and tumor resection has greatly stimulated research in the field regeneration. Generally, healing is a long complicated process wherein manipulating biological activity interventional scaffolds to support long-term regeneration significant for treating bone-related diseases. It been reported that some physical cues can act as growth factor substitutes promote osteogenesis through continuous activation endogenous signaling pathways. This review focuses on latest progress repair remote actuation on-demand biomaterials pre-incorporated with (heat, electricity, magnetism). As an alternative method treat defects, show many advantages, including effectiveness, noninvasiveness, manipulation. First, we introduce impact different potential internal regulatory mechanisms. Subsequently, mediate various their respective characteristics are summarized. Additionally, challenges discussed, aiming provide new insights suggestions developing intelligent defects clinical translation.
Язык: Английский
Процитировано
5Analytica Chimica Acta, Год журнала: 2024, Номер 1338, С. 343589 - 343589
Опубликована: Дек. 25, 2024
Язык: Английский
Процитировано
5