Materials Today Bio,
Год журнала:
2024,
Номер
30, С. 101420 - 101420
Опубликована: Дек. 24, 2024
Fibroblast
activating
protein
(FAP)
is
up-regulated
in
cancer-associated
fibroblasts
(CAFs)
of
more
than
90
%
tumor
microenvironment
and
also
highly
expressed
on
the
surface
multiple
cells
like
glioblastoma,
which
can
be
used
as
a
specific
target
for
diagnosis
treatment.
At
present,
small-molecule
radiotracer
targeting
FAP
with
high
specificity
exhibit
limited
functionality,
hinders
integration
theranostics
well
multifunctionality.
In
this
work,
we
have
engineered
multifunctional
nanoplatform
utilizing
organic
melanin
nanoparticles
that
specifically
targets
FAP,
facilitating
both
multimodal
imaging
synergistic
therapeutic
applications.
This
perform
positron
emission
tomography
(PET),
magnetic
resonance
(MRI)
photoacoustic
(PAI)
strong
near
infrared
absorption
metal
chelating
ability,
achieving
efficiently
accumulation
display
long
retention
region.
Meanwhile,
131I-labeled
targeted
radioisotope
therapy
(TRT)
photothermal
(PTT)
were
significantly
suppressed
growth
glioblastoma
xenograft
models
without
obvious
side
effects.
These
results
demonstrated
novel
nanoparticles-based
effectively
enhance
radionuclide-photothermal
solid
tumors
expression.
Advanced Nanocomposites,
Год журнала:
2024,
Номер
1(1), С. 248 - 274
Опубликована: Янв. 1, 2024
In
light
of
the
pressing
global
issues
surrounding
foodborne
illnesses,
food
waste
and
plastic
pollution
from
packaging,
necessity
for
sustainable,
advanced
packaging
solutions
is
brought
into
sharp
focus.
Alginate,
derived
seaweed,
has
emerged
as
a
focal
point
materials
innovation
due
to
its
renewable
nature,
biodegradability
versatile
functionality.
This
comprehensive
review
examines
recent
developments
in
field
alginate-based
nanocomposites
specifically
designed
use
packaging.
Significant
advancements
entail
incorporation
diverse
nanoparticles—such
polysaccharides,
carbon-based
metallic
species,
metal
oxides,
nanoclays,
layered
double
hydroxides,
carbon
dots
metal–organic
frameworks—into
alginate
matrices.
These
integrations
markedly
elevate
mechanical
robustness,
thermal
stability
barrier
effectiveness
materials.
Furthermore,
these
manifest
antimicrobial,
antioxidant
sensing
capabilities
vital
preservation.
Pioneering
methodologies
encompass
infusion
plant
extracts,
essential
oils
bioactive
compounds,
which
synergistically
enhance
performance
metrics.
The
highlights
practical
applications
materials,
demonstrating
their
prolonging
shelf
life
maintaining
quality
range
products,
such
fresh
produce,
meat
dairy
items.
It
also
presents
forward-thinking
insights
that
advocate
cost-effective
biosafe
nanofiller
exploration,
resource-efficient
process
development
innovative
formulation
strategies
further
amplify
material
functionality
expand
scope
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(25), С. 31950 - 31965
Опубликована: Июнь 11, 2024
Ulcerative
colitis
(UC)
is
a
recurrent
chronic
mucosal
inflammation
disease
whose
most
significant
pathological
characteristics
are
intestinal
and
damaged
barrier
induced
by
reactive
oxygen/nitrogen
species,
abnormal
immune
microenvironment,
microecological
imbalance.
Oral
probiotics
living
therapy
for
diseases,
but
their
clinical
application
hindered
poor
bacterial
biological
activity
insufficient
retention.
Here,
we
developed
targeted
oral
formulation,
functionalized
probiotic
Lf@MPB,
with
Lactobacillus
fermentum
(Lf)
as
the
core
modified
melanin
nanoparticles
(MNPs)
on
its
surface
through
click
reaction
of
tricarboxyphenylboronic
acid
synergistic
UC.
In
vitro
experiments
showed
that
Lf@MPB
not
only
possessed
strong
free
radical
scavenging
ability,
reduced
cellular
mitochondrial
polarization,
inhibited
apoptosis
also
significantly
enhanced
viability
Lf
in
simulated
gastrointestinal
fluid.
Fluorescence
imaging
vivo
revealed
high
accumulation
at
site
dextran
sulfate
sodium-induced
UC
mice.
Moreover,
results
demonstrated
effectively
alleviated
oxidative
stress
inflammatory
response
restored
barrier.
addition,
16S
rRNA
gene
sequencing
verified
could
increase
abundance
diversity
microbial
communities
optimize
composition
to
inhibit
progression
This
work
combines
effective
antioxidant
anti-inflammatory
strategies
administration
provide
promising
alternative
treatment.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 16, 2025
Abstract
Tremendous
research
efforts
have
recently
been
devoted
to
designing
and
developing
melanin‐engineered
metal
metal‐oxide
nanoparticles
with
unconventional
configurations
for
groundbreaking
applications
in
biomedical
settings.
These
surface‐engineered
occupy
a
unique
niche
among
nanomaterials
due
the
distinctive
merits
of
melanin,
such
as
exceptional
biocompatibility,
photophysical
adaptability,
robust
metal‐binding
capabilities.
This
review
provides
comprehensive
heuristic
overview
sustainable
synthesis
strategies
structurally
tunable
that
can
facilitate
controlled
customization
melanin.
Recent
is
highlighted
harnesses
physical
properties
melanin
explore
how
controlling
its
geometrical
features
increase
catalytic
activity,
which
essential
improving
imaging
resolution
therapeutic
efficacy.
Furthermore,
complex
dynamics
oxidative
polymerization
detailed
investigation
melanin's
interface
be
conjugated
components
hybrid
nanostructures
are
critically
analyzed.
The
key
remaining
challenges
summarized
an
outlook
on
future
perspectives
offered.
act
roadmap
guide
both
newcomers
experts
who
interested
learning
about
immense
potential
versatile,
high‐performance
platforms
nanotechnology‐driven
innovations
theranostic
nanomedicine.
