Melanin-Deferoxamine Nanoparticles Targeting Ferroptosis Mitigate Acute Kidney Injury via RONS Scavenging and Iron Ion Chelation DOI
Jinghua Sun, H. F. Shen, Jie Dong

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 17(1), P. 282 - 296

Published: Dec. 20, 2024

Rhabdomyolysis (RM)-induced acute kidney injury (AKI) involves the release of large amounts iron ions from excess myoglobin in kidneys, which mediates overproduction reactive species with onset overload via Fenton reaction, thus inducing ferroptosis and leading to renal dysfunction. Unfortunately, there are no effective treatments for AKI other than supportive care. Herein, we developed a multifunctional nanoplatform (MPD) by covalently bonding melanin nanoparticles (MP NPs) deferoxamine. The has good dispersion physiological stability, excellent chelating performance ions, broad-spectrum scavenging activity. Furthermore, cellular experiments showed that NPs possessed high biocompatibility, antiapoptotic activity, antioxidant properties, strong capacity Fe2+ mitigate overload, protecting intracellular mitochondria oxidative stress. Meanwhile, intrinsic photoacoustic imaging capability allows real-time monitoring MPD NPs' target uptake metabolic behavior healthy mice. Most importantly, led downregulation pathway targeting ferroptosis, effectively rescuing function vivo, mitigating stress inflammatory responses, inhibiting tubular cell apoptosis. offers novel therapeutic strategy RM-induced AKI.

Language: Английский

Alginate-based nanocomposites for food preservation: Recent progress showcasing heightened material properties and functionalities DOI Creative Commons
Fengwei Xie

Advanced Nanocomposites, Journal Year: 2024, Volume and Issue: 1(1), P. 248 - 274

Published: Jan. 1, 2024

In light of the pressing global issues surrounding foodborne illnesses, food waste and plastic pollution from packaging, necessity for sustainable, advanced packaging solutions is brought into sharp focus. Alginate, derived seaweed, has emerged as a focal point materials innovation due to its renewable nature, biodegradability versatile functionality. This comprehensive review examines recent developments in field alginate-based nanocomposites specifically designed use packaging. Significant advancements entail incorporation diverse nanoparticles—such polysaccharides, carbon-based metallic species, metal oxides, nanoclays, layered double hydroxides, carbon dots metal–organic frameworks—into alginate matrices. These integrations markedly elevate mechanical robustness, thermal stability barrier effectiveness materials. Furthermore, these manifest antimicrobial, antioxidant sensing capabilities vital preservation. Pioneering methodologies encompass infusion plant extracts, essential oils bioactive compounds, which synergistically enhance performance metrics. The highlights practical applications materials, demonstrating their prolonging shelf life maintaining quality range products, such fresh produce, meat dairy items. It also presents forward-thinking insights that advocate cost-effective biosafe nanofiller exploration, resource-efficient process development innovative formulation strategies further amplify material functionality expand scope

Language: Английский

Citations

10
Melanin/melanin-like nanoparticles in tumor photothermal and targeted therapies DOI Creative Commons
Jing Wu,

Yilin Xu,

Donghai Wu

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125354 - 125354

Published: Feb. 1, 2025

Language: Английский

Citations

1
Melanin Nanoparticle-Modified Probiotics for Targeted Synergistic Therapy of Ulcerative Colitis DOI

Yuqin Liu,

Caifang Gao,

Gang� Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(25), P. 31950 - 31965

Published: June 11, 2024

Ulcerative colitis (UC) is a recurrent chronic mucosal inflammation disease whose most significant pathological characteristics are intestinal and damaged barrier induced by reactive oxygen/nitrogen species, abnormal immune microenvironment, microecological imbalance. Oral probiotics living therapy for diseases, but their clinical application hindered poor bacterial biological activity insufficient retention. Here, we developed targeted oral formulation, functionalized probiotic Lf@MPB, with Lactobacillus fermentum (Lf) as the core modified melanin nanoparticles (MNPs) on its surface through click reaction of tricarboxyphenylboronic acid synergistic UC. In vitro experiments showed that Lf@MPB not only possessed strong free radical scavenging ability, reduced cellular mitochondrial polarization, inhibited apoptosis also significantly enhanced viability Lf in simulated gastrointestinal fluid. Fluorescence imaging vivo revealed high accumulation at site dextran sulfate sodium-induced UC mice. Moreover, results demonstrated effectively alleviated oxidative stress inflammatory response restored barrier. addition, 16S rRNA gene sequencing verified could increase abundance diversity microbial communities optimize composition to inhibit progression This work combines effective antioxidant anti-inflammatory strategies administration provide promising alternative treatment.

Language: Английский

Citations

7
Quercetin-loaded melanin nanoparticle mediated konjac glucomannan/polycaprolactone bilayer film with dual-mode synergistic bactericidal activity for food packaging DOI
Di Zhang, Nitong Bu,

Lizhen Zhou

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 276, P. 133982 - 133982

Published: July 17, 2024

Language: Английский

Citations

6
Recent advances of intelligent polymer gels as active carriers for medical imaging-guided cancer therapy: A review DOI
Huifang Zhao,

Siyi Jiang,

Shuyu Zhai

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140451 - 140451

Published: Jan. 1, 2025

Language: Английский

Citations

0
Biocompatible and Size-Dependent Melanin-Like Nanocapsules for Efficient Therapy in Hyperoxia-Induced Acute Lung Injury DOI

Yong Sheng Han,

Jie Dong, Liyan Zhang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123169 - 123169

Published: Feb. 5, 2025

Language: Английский

Citations

0
Multienzyme Active Melanin Nanodots for Antioxidant-Immunomodulatory Therapy of Hyperoxia Lung Injury DOI Creative Commons
Jinghua Sun, Juan Wu,

Wenjing Zhao

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101609 - 101609

Published: Feb. 25, 2025

Language: Английский

Citations

0
Optical and electrical properties of cadmium sulphide thin films coated with fungal-derived core/shell silver nanoparticles DOI
Claudia Oviedo,

M. Salamanca-Flores,

Arturo Fernández-Pérez

et al.

Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: unknown, P. 106166 - 106166

Published: March 1, 2025

Language: Английский

Citations

0
Implementing differentially pigmented skin models for predicting drug response variability across human ancestries DOI Creative Commons
Sophie Zaaijer, Simon C. Groen

Human Genomics, Journal Year: 2024, Volume and Issue: 18(1)

Published: Oct. 9, 2024

Persistent racial disparities in health outcomes have catalyzed legislative reforms and heightened scientific focus recently. However, despite the well-documented properties of skin pigments binding drug compounds, their impact on therapeutic efficacy adverse responses remains insufficiently explored. This perspective examines intricate relationships between variation melanin-based pigmentation pharmacokinetics -dynamics, highlighting need for considering diversity as a variable to advance equitability pharmacological interventions. The article provides guidelines selection New Approach Methods (NAMs) foster inclusive study designs preclinical development pipelines, leading an improved level translatability clinic.

Language: Английский

Citations

1
Capsaicin-Loaded Melanin Nanoparticles for Long-Lasting Nociceptive-Selective Nerve Blockade DOI
Xiaosi Li, Qi Li,

Xinyu Xia

et al.

Langmuir, Journal Year: 2024, Volume and Issue: 40(47), P. 24751 - 24760

Published: Nov. 14, 2024

Clinically used amino-ester and amino-amide local anesthetics, such as bupivacaine lidocaine, face two primary challenges: inadequate duration of action nonselective on both sensory motor neurons, resulting in function loss alongside pain relief. In this work, we developed capsaicin-loaded melanin nanoparticles (Cap-MNPs) to address these challenges. Capsaicin selectively acts neurons without affecting thereby achieving nociceptive-selective nerve blockade. Melanin is known for its exceptional biocompatibility, biodegradability, abundance pigmented human tissue. Melanin's inherent chemical structure hydrophobic nature enable the encapsulation sustained release anesthetics with aromatic rings through π-π interactions interactions. The drug loading efficiency Cap-MNPs was 82.99 ± 1.55%, capacity 67.47 4.24%, capsaicin continuously released more than 360 h. rats, a single injection containing 8.04 mg produced sciatic block lasting 6 h causing any toxicity capsaicin-related systemic toxicity. show promise clinically useful therapeutics management.

Language: Английский

Citations

1