Therapeutic Potential of Microneedle Assisted Drug Delivery for Wound Healing: Current State of the Art, Challenges, and Future Perspective

AAPS PharmSciTech, Год журнала: 2025, Номер 26(1)

Опубликована: Янв. 8, 2025

Язык: Английский

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Kill Two Birds with One Stone: Dual‐Metal MOF‐Nanozyme‐Decorated Hydrogels with ROS‐Scavenging, Oxygen‐Generating, and Antibacterial Abilities for Accelerating Infected Diabetic Wound Healing

Small, Год журнала: 2024, Номер unknown

Опубликована: Сен. 6, 2024

Abstract Diabetic wounds tend to develop into nonhealing associated with the complex inflammatory microenvironment of uncontrollable bacterial infection, reactive oxygen species (ROS) accumulation, and chronic hypoxia. Damaged blood vessels hinder metabolic circulation, aggravating hypoxia, ROS accumulation further exacerbating diabetic wound microenvironment. However, existing treatments a single functionality have difficulty healing complicated wounds. Therefore, developing an integrative strategy improve hostility is urgently needed. Herein, multifunctional genipin (GP)‐crosslinked chitosan (CS)‐based hydrogels decorated biomimetic metal–organic framework (MOF)‐nanozymes natural antibacterial agent chlorogenic acid (CGA), which named MOF/CGA@GP‐CS (MCGC), are prepared. With catalase (CAT)‐like activity, these dual‐metal MOF‐nanozymes promising bioreactors for simultaneously alleviating hypoxia by converting elevated endogenous H 2 O dissolved in In addition, other component polyphenolic CGA acts as mild agent, efficiently inhibiting infection avoiding antibiotic resistance. Impressively, MCGC accelerate infected eliminating oxidative stress, increasing oxygenation, reversing vivo. this work, effective based on hydrogel dressings successfully developed applied management.

Язык: Английский

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Glucose-triggered NIR-responsive photothermal antibacterial gelatin/dextran hydrogel simultaneously targeting the high glucose and infection microenvironment in diabetic wound

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140325 - 140325

Опубликована: Янв. 1, 2025

Язык: Английский

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Recent advances in hyaluronic acid-based hydrogels for diabetic wound healing

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 304, С. 140797 - 140797

Опубликована: Фев. 7, 2025

Язык: Английский

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Nanomaterials-incorporated polymeric microneedles for wound healing applications

International Journal of Pharmaceutics, Год журнала: 2024, Номер 659, С. 124247 - 124247

Опубликована: Май 22, 2024

Язык: Английский

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Development of Microneedles for Antimicrobial Drug Delivery: A Comprehensive Review on Applications in Wound Infection Management

Small Science, Год журнала: 2024, Номер unknown

Опубликована: Июль 21, 2024

Microneedles (MNs) have emerged as a promising transdermal antimicrobial delivery system, providing precise and localized drug while complemented with noninvasiveness patient compliance. Currently, the topical application of antimicrobials restricts drugs to critical areas wound bed, largely due barriers posed by necrotic tissue, scab formation, bacterial biofilms, which severely diminish bioavailability therapeutics. MNs enabled efficient targeted overcome many chronic challenges. Over past decade, significant progress has been made develop unique properties tailored for vaccines, anticancer, antimicrobials. As ongoing research continues refine MN design, material properties, formulations, potential revolutionizing efficacy, experience, therapeutic outcomes remains at forefront scientific research. In this review, insights are provided into latest progress, current developments, diverse applications delivery. Herein, translational is highlighted perspective on challenges associated clinical translation provided. Furthermore, review aids in identifying gaps empowering contributing future implementation cutting‐edge systems effectively tackle resistance.

Язык: Английский

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Swellable Microneedles in Drug Delivery and Diagnostics

Pharmaceuticals, Год журнала: 2024, Номер 17(6), С. 791 - 791

Опубликована: Июнь 16, 2024

This manuscript explores the transformative potential of swellable microneedles (MNs) in drug delivery and diagnostics, addressing critical needs medical treatment monitoring. Innovations hydrogel-integrated MN arrays facilitate controlled release, thereby expanding options for chronic diseases conditions that require precise dosage control. The review covers challenges, such as scalability, patient compliance, manufacturing processes, well achievements advanced manufacturing, biocompatibility, versatile applications. Nonetheless, limitations physiological responsiveness long-term stability remain, necessitating further research material innovation integration with digital technologies. Future directions focus on biomedical applications, advancements, regulatory considerations widespread clinical adoption.

Язык: Английский

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Research Progress of Hydrogel Microneedles in Wound Management

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(8), С. 4771 - 4790

Опубликована: Июль 10, 2024

Microneedles are a novel drug delivery system that offers advantages such as safety, painlessness, minimally invasive administration, simplicity of use, and controllable delivery. As type polymer microneedle with three-dimensional network structure, hydrogel microneedles (HMNs) possess excellent biocompatibility biodegradability encapsulate various therapeutic drugs while maintaining activity, thus attracting significant attention. Recently, they have been widely employed to promote wound healing demonstrated favorable effects. Although there reviews about HMNs, few them focus on management. Herein, we present comprehensive overview the design preparation methods particular emphasis their application status in healing, including acute infected diabetic scarless healing. Finally, examine limitations HMNs management provide suggestions for future research directions.

Язык: Английский

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Microneedles in diabetic wound care: multifunctional solutions for enhanced healing

Burns & Trauma, Год журнала: 2025, Номер 13

Опубликована: Янв. 1, 2025

Abstract Diabetic wounds present a significant challenge in clinical treatment and are characterized by chronic inflammation, oxidative stress, impaired angiogenesis, peripheral neuropathy, heightened risk of infection during the healing process. By creating small channels surface skin, microneedle technology offers minimally invasive efficient approach for drug delivery treatment. This article begins outlining biological foundation normal skin wound unique pathophysiological mechanisms diabetic wounds. It then delves into various types, materials, preparation processes microneedles. The focus is on application multifunctional microneedles treatment, highlighting their antibacterial, anti-inflammatory, immunomodulatory, antioxidant, angiogenic neural repair properties. These demonstrate synergistic therapeutic effects directly influencing microenvironment, ultimately accelerating advancement not only holds promise enhancing outcomes but also new strategies addressing other

Язык: Английский

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Breathable functional aerogel dressings facilitate the healing of diabetic wounds

Biomedical Technology, Год журнала: 2025, Номер 9, С. 100071 - 100071

Опубликована: Фев. 21, 2025

Язык: Английский

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