International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(9), С. 4267 - 4267
Опубликована: Апрель 30, 2025
Designing
a
highly
sensitive
and
efficient
functionalized
electrode
for
precise
drug
analysis
remains
significant
challenge.
In
this
work,
an
electrochemical
sensor
based
on
glassy
carbon
(GCE)
modified
with
phenyl
diazonium
salts
(ph)
electrochemically
reduced
graphene
oxide
(ERGO),
labeled
GCE/ph/ERGO,
was
developed
the
detection
of
paracetamol
(PAR)
in
pharmaceutical
matrices
using
square
wave
voltammetry
(SWV).
The
characterized
by
scanning
electron
microscopy
(SEM),
impedance
spectroscopy
(EIS),
cyclic
(CV).
Compared
to
bare
GCE,
GCE/ph/ERGO
demonstrated
significantly
improved
conductivity
anodic
current
peak
PAR
over
two
orders
magnitude
higher,
indicating
substantial
enhancement
performance.
Under
optimized
conditions,
exhibited
low
limit
18.2
nM
quantification
60.6
nM.
Precision
studies
yielded
relative
standard
deviations
(RSDs)
below
8%.
excellent
selectivity
presence
common
excipients
high
accuracy
generic
formulations,
results
comparable
those
obtained
HPLC
technique.
These
findings
confirm
sensor's
reliability,
stability,
robustness,
suitability
routine
samples.
Biosensors,
Год журнала:
2023,
Номер
13(4), С. 453 - 453
Опубликована: Апрель 3, 2023
Electrochemical
sensors
consisting
of
screen-printed
electrodes
(SPEs)
are
recurrent
devices
in
the
recent
literature
for
applications
different
fields
interest
and
contribute
to
expanding
electroanalytical
chemistry
field.
This
is
due
inherent
characteristics
that
can
be
better
(or
only)
achieved
with
use
SPEs,
including
miniaturization,
cost
reduction,
lower
sample
consumption,
compatibility
portable
equipment,
disposability.
SPEs
also
quite
versatile;
they
manufactured
using
formulations
conductive
inks
substrates,
varied
designs.
Naturally,
analytical
performance
directly
affected
by
quality
material
used
printing
modifying
electrodes.
In
this
sense,
most
carbon
nanomaterials
have
been
explored
preparation
modification
providing
an
enhanced
electrochemical
response
greater
sensitivity,
addition
functionalized
surfaces
immobilize
biological
agents
manufacture
biosensors.
Considering
relevance
timeliness
topic,
review
aimed
provide
overview
current
scenario
carbonaceous
context
making
SPE
sensors,
from
which
approaches
will
presented,
exploring
materials
traditionally
investigated
electrochemistry,
such
as
graphene,
nanotubes,
black,
those
more
recently
(carbon
quantum
dots,
graphitic
nitride,
biochar).
Perspectives
on
expansion
these
considered.
ECS Sensors Plus,
Год журнала:
2024,
Номер
3(1), С. 011601 - 011601
Опубликована: Март 1, 2024
There
is
a
plethora
of
electrochemical
biosensors
developed
for
ultrasensitive
detection
clinically
relevant
biomarkers.
However,
many
these
systems
lose
their
performance
in
heterogeneous
clinical
samples
and
are
too
complex
to
be
operated
by
end
users
at
the
point-of-care
(POC),
prohibiting
commercial
success.
Integration
with
sample
processing
technology
addresses
both
challenges;
however,
it
adds
manufacturing
complexity
overall
cost
systems.
Herein,
we
review
different
components
biosensor
avenues
creating
fully
integrated
In
context
integration,
focus
on
discussing
trade-offs
between
sensing
performance,
cost,
scalable
guide
readers
toward
designing
new
commercialization
potential.
Biosensors,
Год журнала:
2023,
Номер
13(2), С. 211 - 211
Опубликована: Янв. 31, 2023
Catecholamines,
including
dopamine,
epinephrine,
and
norepinephrine,
are
considered
one
of
the
most
crucial
subgroups
neurotransmitters
in
central
nervous
system
(CNS),
which
they
act
at
brain’s
highest
levels
mental
function
play
key
roles
neurological
disorders.
Accordingly,
analysis
such
catecholamines
biological
samples
has
shown
a
great
interest
clinical
pharmaceutical
importance
toward
early
diagnosis
diseases
as
Epilepsy,
Parkinson,
Alzheimer
diseases.
As
promising
routes
for
real-time
monitoring
catecholamine
neurotransmitters,
optical
electrochemical
biosensors
have
been
widely
adopted
perceived
dramatically
accelerating
development
last
decade.
Therefore,
this
review
aims
to
provide
comprehensive
overview
on
recent
advances
main
challenges
biosensors.
Particular
emphasis
is
given
biosensors,
reviewing
their
sensing
mechanism
unique
characteristics
brought
by
emergence
nanotechnology.
Based
specific
biosensors’
performance
metrics,
multiple
perspectives
therapeutic
use
nanomaterial
future
trends
also
summarized.
RSC Advances,
Год журнала:
2024,
Номер
14(38), С. 27957 - 27971
Опубликована: Янв. 1, 2024
Disposable
adlayer
modified
screen-printed
electrodes
have
become
extremely
useful
devices
for
ensuring
food
safety
and
quality
assessment
because
of
their
adaptability,
affordability,
convenience
use.
Biosensors,
Год журнала:
2025,
Номер
15(3), С. 166 - 166
Опубликована: Март 4, 2025
In
recent
decades,
the
utilization
of
biomarkers
has
gained
increasing
attention.
The
timely
identification
and
quantification
proteins,
nucleic
acids,
small
molecules
associated
with
a
medical
condition,
infection,
or
contaminant
have
become
increasingly
crucial
across
variety
fields,
including
medicine,
food
safety,
quality/environmental
control.
State-of-the-art
biomarker
detection
methods
predominantly
rely
on
standard
immunoassay
techniques,
requiring
specialized
laboratory
equipment
trained
personnel.
This
impedes
broad
commercial
implementation
biosensors
in,
e.g.,
Point-of-Care
(PoC)
settings
where
ease
operation,
portability,
cost-efficiency
are
prioritized.
Small,
robust
electrochemical
promising
alternative
for
analyzing
in
complex
samples
within
PoC
environments.
Therefore,
creating
designing
optimized
sensing
surfaces,
immobilization
strategies,
efficient
signal
generation
improving
biosensor
systems,
which
turn
can
real-world
impact.
present
paper,
we
reviewed
common
electrode
types
geometries
used
approaches,
discussed
advantages
drawbacks
different
methods,
presented
labeling
strategies
enhancement.
Frontiers in Medical Technology,
Год журнала:
2024,
Номер
6
Опубликована: Фев. 15, 2024
Herein,
advancements
in
electroanalytical
devices
for
the
simultaneous
detection
of
diverse
breast
cancer
(BC)
markers
are
demonstrated.
This
article
identifies
several
important
areas
exploration
electrochemical
diagnostics
and
highlights
factors
that
pivotal
successful
deployment
novel
bioanalytical
devices.
We
have
highlighted
limits
(LOD)
reported
multiplex
biosensor
can
surpass
sensitivity
displayed
by
current
clinical
standards
such
as
ELISA,
FISH,
PCR.
HER-2;
a
marker
characterised
increased
metastatic
potential,
more
aggressive
development,
poor
outcomes;
be
sensed
with
LOD
0.5
ng/ml
using
platforms,
which
falls
within
range
measured
ELISA
(from
picogram/ml
to
nanogram/ml).
Electrochemical
biosensors
0.53
0.21
U/ml
MUC-1
CA
15-3,
respectively,
or
5.8
×
10
