Electrochemistry Test Strip as Platform for In Situ Detection of Blood Levels of Antipsychotic Clozapine in Finger-Pricked Sample Volume DOI Creative Commons
Mehmet Şenel

Biosensors, Journal Year: 2023, Volume and Issue: 13(3), P. 346 - 346

Published: March 4, 2023

With the increasing number of patients suffering from Parkinson's disease, importance measuring drug levels in patient body fluids has increased exponentially, particularly for clozapine. There is a growing demand real-time analysis biofluids on single low-cost platform ultra-low fluid volumes with robustness. This study aims to measure level clozapine (Clz) portable potentiostat using practical approach. For this purpose, we developed an inexpensive, via electrochemistry commercial glucose test strip (CTS). CTSs were first modified by removing enzyme mixture surface sensing zone, which was followed modification Multi walled carbon nanotube (MWCNT) and Nafion. The electrochemical characteristics CTS electrodes investigated cyclic voltammetry (CV) differential (DPV) techniques. designed sensor displayed decent linear range, detection limit, reproducibility, reusability results. A dynamic range 0.1-5 μM observed under optimized conditions good sensitivity (1.295 μA/μM) limit (83 nM). Furthermore, electrode used amount Clz real samples.

Language: Английский

Carbon Nanomaterials-Based Screen-Printed Electrodes for Sensing Applications DOI Creative Commons

Rafael Matias Silva,

Alexsandra Dias da Silva,

Jéssica Rocha Camargo

et al.

Biosensors, Journal Year: 2023, Volume and Issue: 13(4), P. 453 - 453

Published: April 3, 2023

Electrochemical sensors consisting of screen-printed electrodes (SPEs) are recurrent devices in the recent literature for applications different fields interest and contribute to expanding electroanalytical chemistry field. This is due inherent characteristics that can be better (or only) achieved with use SPEs, including miniaturization, cost reduction, lower sample consumption, compatibility portable equipment, disposability. SPEs also quite versatile; they manufactured using formulations conductive inks substrates, varied designs. Naturally, analytical performance directly affected by quality material used printing modifying electrodes. In this sense, most carbon nanomaterials have been explored preparation modification providing an enhanced electrochemical response greater sensitivity, addition functionalized surfaces immobilize biological agents manufacture biosensors. Considering relevance timeliness topic, review aimed provide overview current scenario carbonaceous context making SPE sensors, from which approaches will presented, exploring materials traditionally investigated electrochemistry, such as graphene, nanotubes, black, those more recently (carbon quantum dots, graphitic nitride, biochar). Perspectives on expansion these considered.

Language: Английский

Citations

43
Editors’ Choice—Challenges and Opportunities for Developing Electrochemical Biosensors with Commercialization Potential in the Point-of-Care Diagnostics Market DOI Creative Commons
A. Akhlaghi, Harmanjit Kaur, Bal Ram Adhikari

et al.

ECS Sensors Plus, Journal Year: 2024, Volume and Issue: 3(1), P. 011601 - 011601

Published: March 1, 2024

There is a plethora of electrochemical biosensors developed for ultrasensitive detection clinically relevant biomarkers. However, many these systems lose their performance in heterogeneous clinical samples and are too complex to be operated by end users at the point-of-care (POC), prohibiting commercial success. Integration with sample processing technology addresses both challenges; however, it adds manufacturing complexity overall cost systems. Herein, we review different components biosensor avenues creating fully integrated In context integration, focus on discussing trade-offs between sensing performance, cost, scalable guide readers toward designing new commercialization potential.

Language: Английский

Citations

35
Advanced Nanomaterials-Based Electrochemical Biosensors for Catecholamines Detection: Challenges and Trends DOI Creative Commons
Zina Fredj, Mohamad Sawan

Biosensors, Journal Year: 2023, Volume and Issue: 13(2), P. 211 - 211

Published: Jan. 31, 2023

Catecholamines, including dopamine, epinephrine, and norepinephrine, are considered one of the most crucial subgroups neurotransmitters in central nervous system (CNS), which they act at brain’s highest levels mental function play key roles neurological disorders. Accordingly, analysis such catecholamines biological samples has shown a great interest clinical pharmaceutical importance toward early diagnosis diseases as Epilepsy, Parkinson, Alzheimer diseases. As promising routes for real-time monitoring catecholamine neurotransmitters, optical electrochemical biosensors have been widely adopted perceived dramatically accelerating development last decade. Therefore, this review aims to provide comprehensive overview on recent advances main challenges biosensors. Particular emphasis is given biosensors, reviewing their sensing mechanism unique characteristics brought by emergence nanotechnology. Based specific biosensors’ performance metrics, multiple perspectives therapeutic use nanomaterial future trends also summarized.

Language: Английский

Citations

39
Nanomaterials-modified disposable electrodes and portable electrochemical systems for heavy metals detection in wastewater streams: A review DOI
Yasser GadelHak,

Sarah H.M. Hafez,

Hamdy F. M. Mohamed

et al.

Microchemical Journal, Journal Year: 2023, Volume and Issue: 193, P. 109043 - 109043

Published: July 1, 2023

Language: Английский

Citations

33
Revolutionizing cancer monitoring with carbon-based electrochemical biosensors DOI
Fatemeh Karimi, Hassan Karimi‐Maleh,

Jalal Rouhi

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 239, P. 117368 - 117368

Published: Oct. 10, 2023

Language: Английский

Citations

29
Applications of chemically modified screen-printed electrodes in food analysis and quality monitoring: a review DOI Creative Commons

Kavitha Kamalasekaran,

Ashok K. Sundramoorthy

RSC Advances, Journal Year: 2024, Volume and Issue: 14(38), P. 27957 - 27971

Published: Jan. 1, 2024

Disposable adlayer modified screen-printed electrodes have become extremely useful devices for ensuring food safety and quality assessment because of their adaptability, affordability, convenience use.

Language: Английский

Citations

10
Aptasensing of beta-amyloid (Aβ(1−42)) by a 3D-printed platform integrated with leaf-shaped gold nanodendrites DOI Open Access
Masoud Negahdary, William B. Veloso, Raphael P. Bacil

et al.

Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 393, P. 134130 - 134130

Published: June 12, 2023

Language: Английский

Citations

16
Multiplex electrochemical sensing platforms for the detection of breast cancer biomarkers DOI Creative Commons
Connor O’Brien,

Chun Keat Khor,

Sina Ardalan

et al.

Frontiers in Medical Technology, Journal Year: 2024, Volume and Issue: 6

Published: Feb. 15, 2024

Herein, advancements in electroanalytical devices for the simultaneous detection of diverse breast cancer (BC) markers are demonstrated. This article identifies several important areas exploration electrochemical diagnostics and highlights factors that pivotal successful deployment novel bioanalytical devices. We have highlighted limits (LOD) reported multiplex biosensor can surpass sensitivity displayed by current clinical standards such as ELISA, FISH, PCR. HER-2; a marker characterised increased metastatic potential, more aggressive development, poor outcomes; be sensed with LOD 0.5 ng/ml using platforms, which falls within range measured ELISA (from picogram/ml to nanogram/ml). Electrochemical biosensors 0.53 0.21 U/ml MUC-1 CA 15-3, respectively, or 5.8 × 10

Language: Английский

Citations

5
Development and characterization of a portable electrochemical aptasensor for IsdA protein and Staphylococcus aureus detection DOI
Shokoufeh Soleimani, Tracy Ann Bruce‐Tagoe, Najeeb Ullah

et al.

Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: 416(20), P. 4619 - 4634

Published: June 25, 2024

Language: Английский

Citations

5
Nanogenosensors based on aptamers and peptides for bioelectrochemical cancer detection: an overview of recent advances in emerging materials and technologies DOI Creative Commons
Babak Mikaeeli Kangarshahi, Seyed Morteza Naghib

Deleted Journal, Journal Year: 2024, Volume and Issue: 6(2)

Published: Jan. 31, 2024

Abstract Electrochemical biosensors fabricated based on nucleic acids have shown great potential for cancer recognition because of their low cost, fast feedback, high sensitivity, and easy operation. This review will demonstrate the impression recent advances applications electrochemical that are acid-based detection. We compare formulated with those formed antibodies highlight some examples developed detection, such as use DNA or RNA aptamers to detect prostate-specific antigens, microRNA-21, carcinoembryonic antigens. discuss rewards drawbacks these challenges they face, stability, reproducibility, interference, standardization. also suggest possible directions opportunities future research development, developing novel acid elements, exploring new transducer materials configurations, designing signal amplification strategies, integrating microfluidic devices portable instruments, evaluating in clinical settings actual samples from patients healthy donors. Overall, we believe offer an auspicious alternative conventional methods detection contribute early diagnosis effective treatment. Graphical

Language: Английский

Citations

4