Pharmaceutical Development and Technology,
Год журнала:
2022,
Номер
27(5), С. 525 - 544
Опубликована: Май 28, 2022
The
bioavailability
of
drugs
is
dependent
on
several
factors
such
as
solubility
and
the
administration
route.
A
drug
with
poor
aqueous
solubility,
therefore,
poses
challenges
regards
to
its
pharmaceutical
advance
ultimately
biological
usage.
Lipid
nanoparticles
have
been
used
in
science
due
their
importance
green
chemistry.
Their
biochemical
properties
‘green’
materials
processes
mean
they
can
be
environmentally
sustainable.
Generally,
lipid
employed
carriers
for
both
lipophilic
hydrophilic
drugs.
proposed
route
present
advantages
disadvantages
which
should
considered
by
a
formulator.
Solid
(SLNs)
nanostructured
(NLCs)
are
attractive
delivery
systems
because
ease
manufacture,
biocompatibility,
biodegradability,
scale-up
capacity
formulation
constituents.
easy
simple
scalability
novel
SLNs
nano
carriers,
along
various
processing
procedures,
recent
developments,
limitation
toxicity,
optimization
approaches
manufacture
nanoparticles,
lyophilization
release
comprehensively
discussed
this
review.
This
review
also
summarizes
research
data
related
preparation
methods
excipients
NLCs
years.
Cancers,
Год журнала:
2024,
Номер
16(13), С. 2478 - 2478
Опубликована: Июль 7, 2024
The
rise
of
drug
resistance
in
cancer
cells
presents
a
formidable
challenge
modern
oncology,
necessitating
the
exploration
innovative
therapeutic
strategies.
This
review
investigates
latest
advancements
overcoming
mechanisms
employed
by
cells,
focusing
on
emerging
modalities.
intricate
molecular
insights
into
resistance,
including
genetic
mutations,
efflux
pumps,
altered
signaling
pathways,
and
microenvironmental
influences,
are
discussed.
Furthermore,
promising
avenues
offered
targeted
therapies,
combination
treatments,
immunotherapies,
precision
medicine
approaches
highlighted.
Specifically,
synergistic
effects
combining
traditional
cytotoxic
agents
with
molecularly
inhibitors
to
circumvent
pathways
examined.
Additionally,
evolving
landscape
immunotherapeutic
interventions,
immune
checkpoint
adoptive
cell
is
explored
terms
bolstering
anti-tumor
responses
evasion
mechanisms.
Moreover,
significance
biomarker-driven
strategies
for
predicting
monitoring
treatment
underscored,
thereby
optimizing
outcomes.
For
future
direction
paradigms,
current
focused
prevailing
challenges
improving
patient
outcomes,
through
an
integrative
analysis
these
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 746 - 746
Опубликована: Фев. 23, 2023
Nanomedicine
is
currently
focused
on
the
design
and
development
of
nanocarriers
that
enhance
drug
delivery
to
brain
address
unmet
clinical
needs
for
treating
neuropsychiatric
disorders
neurological
diseases.
Polymer
lipid-based
carriers
are
advantageous
central
nervous
system
(CNS)
due
their
safety
profiles,
drug-loading
capacity,
controlled-release
properties.
nanoparticles
(NPs)
reported
penetrate
blood–brain
barrier
(BBB)
have
been
extensively
assessed
in
vitro
animal
models
glioblastoma,
epilepsy,
neurodegenerative
disease.
Since
approval
by
Food
Drug
Administration
(FDA)
intranasal
esketamine
treatment
major
depressive
disorder,
administration
has
emerged
as
an
attractive
route
bypass
BBB
CNS.
NPs
can
be
specifically
designed
tailoring
size
coating
with
mucoadhesive
agents
or
other
moieties
promote
transport
across
nasal
mucosa.
In
this
review,
unique
characteristics
polymeric
desirable
explored
addition
potential
repurposing
CNS
disorders.
Progress
using
nanostructures
treatments
various
diseases
also
described.
