Nanomaterials,
Год журнала:
2021,
Номер
11(12), С. 3432 - 3432
Опубликована: Дек. 17, 2021
Magnetic
nanoparticles
(MNPs)
have
been
studied
for
diagnostic
purposes
decades.
Their
high
surface-to-volume
ratio,
dispersibility,
ability
to
interact
with
various
molecules
and
superparamagnetic
properties
are
at
the
core
of
what
makes
MNPs
so
promising.
They
applied
in
a
multitude
areas
medicine,
particularly
Resonance
Imaging
(MRI).
Iron
oxide
(IONPs)
most
well-accepted
based
on
their
excellent
low
toxicity.
Nevertheless,
IONPs
facing
many
challenges
that
make
entry
into
market
difficult.
To
overcome
these
challenges,
research
has
focused
developing
better
safety
profiles
enhanced
magnetic
properties.
One
important
strategy
includes
doping
(particularly
IONPs)
other
metallic
elements,
such
as
cobalt
(Co)
manganese
(Mn),
reduce
iron
(Fe)
content
released
body
resulting
creation
multimodal
unique
Another
approach
development
using
metals
besides
Fe,
possess
great
or
imaging
The
future
this
field
seems
be
production
which
can
used
multipurpose
platforms
combine
different
uses
MRI
techniques
design
more
effective
complete
tests.
ACS Nano,
Год журнала:
2022,
Номер
16(7), С. 9994 - 10041
Опубликована: Июнь 22, 2022
Worldwide
nanotechnology
development
and
application
have
fueled
many
scientific
advances,
but
technophilic
expectations
technophobic
demands
must
be
counterbalanced
in
parallel.
Some
of
the
burning
issues
today
are
following:
(1)
Where
is
nano
today?
(2)
How
good
communication
investment
networks
between
academia/research
governments?
(3)
Is
there
any
spotlight
for
nanotechnology?
Nanomedicine
a
particular
arm
within
healthcare
landscape,
focused
on
diagnosis,
treatment,
monitoring
emerging
(such
as
coronavirus
disease
2019,
COVID-19)
contemporary
(including
diabetes,
cardiovascular
diseases,
neurodegenerative
disorders,
cancer)
diseases.
However,
it
may
only
represent
bright
side
coin.
In
fact,
recent
past,
concept
nanotoxicology
has
emerged
to
address
dark
shadows
nanomedicine.
The
nanomedicine
field
requires
more
nanotoxicological
studies
identify
undesirable
effects
guarantee
safety.
Here,
we
provide
an
overall
perspective
central
pieces
giant
puzzle
nanotechnology.
First,
impact
education
research
highlighted,
followed
by
market
trends
output
tendencies.
next
section,
dilemma
addressed
through
interplay
silico,
vitro,
vivo
models
with
support
omics
microfluidic
approaches.
Lastly,
reflection
regulatory
clinical
trials
provided.
Finally,
some
conclusions
future
perspectives
proposed
clearer
safer
translation
nanomedicines
from
bench
bedside.
Infectious
virus
outbreaks
pose
a
significant
challenge
to
public
healthcare
systems.
Early
and
accurate
diagnosis
is
critical
prevent
the
spread
of
virus,
especially
when
no
specific
vaccine
or
effective
medicine
available.
In
clinics,
most
commonly
used
viral
detection
methods
are
molecular
techniques
that
involve
measurement
nucleic
acids
proteins
biomarkers.
However,
clinic-based
require
complex
infrastructure
expensive
equipment,
which
not
suitable
for
low-resource
settings.
Over
past
years,
smartphone-based
point-of-care
testing
(POCT)
has
rapidly
emerged
as
potential
alternative
laboratory-based
clinical
diagnosis.
This
review
summarizes
latest
development
detection.
First,
POCT-based
diagnostic
compared,
both
rely
on
immunosensing
acid
Then,
various
POCT
techniques,
including
optical
biosensors,
electrochemical
other
types
biosensors
discussed.
Moreover,
this
covers
diagnostics
viruses
COVID-19,
Ebola,
influenza,
Zika,
HIV,
et
al.
Finally,
prospects
challenges
It
believed
will
aid
researchers
better
understand
current
achieving
ultimate
goal
containing
disease-causing
worldwide.
Biosensors,
Год журнала:
2022,
Номер
12(6), С. 385 - 385
Опубликована: Июнь 2, 2022
The
development
of
new
biosensor
technologies
and
their
active
use
as
wearable
devices
have
offered
mobility
flexibility
to
conventional
western
medicine
personal
fitness
tracking.
In
the
biosensors,
transducers
stand
out
main
elements
converting
signals
sourced
from
a
biological
event
into
detectable
output.
Combined
with
suitable
bio-receptors
miniaturization
readout
electronics,
functionality
design
play
key
role
in
construction
for
health
control.
Ever-growing
research
industrial
interest
transducer
point-of-care
(POC)
bio-detection
gained
tremendous
acceleration
by
pandemic-induced
digital
transformation.
this
article,
we
provide
comprehensive
review
biosensors
applications
that
empower
users
tracking
biomarkers
parameters.
Nanomaterials,
Год журнала:
2023,
Номер
13(7), С. 1247 - 1247
Опубликована: Март 31, 2023
The
introduction
of
point-of-care
testing
(POCT)
has
revolutionized
medical
by
allowing
for
simple
tests
to
be
conducted
near
the
patient's
care
point,
rather
than
being
confined
a
laboratory.
This
been
especially
beneficial
developing
countries
with
limited
infrastructure,
where
often
involves
sending
specimens
off-site
and
waiting
hours
or
days
results.
However,
development
POCT
devices
challenging,
simplicity,
accuracy,
cost-effectiveness
key
factors
in
making
these
feasible.
Nanotechnology
played
crucial
role
achieving
this
goal,
not
only
possible
but
also
masking
their
complexity.
In
article,
recent
developments
that
benefit
from
nanotechnology
are
discussed.
Microfluidics
lab-on-a-chip
technologies
highlighted
as
major
drivers
testing,
particularly
infectious
disease
diagnosis.
These
enable
various
bioassays
used
at
point
care.
article
addresses
challenges
faced
technological
advances
interesting
future
trends.
benefits
significant,
is
shifting
towards
prevention,
early
detection,
managing
chronic
conditions.
Infectious
low-income
can
lead
prompt
treatment,
preventing
infections
spreading.
