Where Is Nano Today and Where Is It Headed? A Review of Nanomedicine and the Dilemma of Nanotoxicology

ACS Nano, Journal Year: 2022, Volume and Issue: 16(7), P. 9994 - 10041

Published: June 22, 2022

Worldwide nanotechnology development and application have fueled many scientific advances, but technophilic expectations technophobic demands must be counterbalanced in parallel. Some of the burning issues today are following: (1) Where is nano today? (2) How good communication investment networks between academia/research governments? (3) Is there any spotlight for nanotechnology? Nanomedicine a particular arm within healthcare landscape, focused on diagnosis, treatment, monitoring emerging (such as coronavirus disease 2019, COVID-19) contemporary (including diabetes, cardiovascular diseases, neurodegenerative disorders, cancer) diseases. However, it may only represent bright side coin. In fact, recent past, concept nanotoxicology has emerged to address dark shadows nanomedicine. The nanomedicine field requires more nanotoxicological studies identify undesirable effects guarantee safety. Here, we provide an overall perspective central pieces giant puzzle nanotechnology. First, impact education research highlighted, followed by market trends output tendencies. next section, dilemma addressed through interplay silico, vitro, vivo models with support omics microfluidic approaches. Lastly, reflection regulatory clinical trials provided. Finally, some conclusions future perspectives proposed clearer safer translation nanomedicines from bench bedside.

Language: Английский

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Virus Detection: From State‐of‐the‐Art Laboratories to Smartphone‐Based Point‐of‐Care Testing

Advanced Science, Journal Year: 2022, Volume and Issue: 9(17)

Published: April 7, 2022

Infectious virus outbreaks pose a significant challenge to public healthcare systems. Early and accurate diagnosis is critical prevent the spread of virus, especially when no specific vaccine or effective medicine available. In clinics, most commonly used viral detection methods are molecular techniques that involve measurement nucleic acids proteins biomarkers. However, clinic-based require complex infrastructure expensive equipment, which not suitable for low-resource settings. Over past years, smartphone-based point-of-care testing (POCT) has rapidly emerged as potential alternative laboratory-based clinical diagnosis. This review summarizes latest development detection. First, POCT-based diagnostic compared, both rely on immunosensing acid Then, various POCT techniques, including optical biosensors, electrochemical other types biosensors discussed. Moreover, this covers diagnostics viruses COVID-19, Ebola, influenza, Zika, HIV, et al. Finally, prospects challenges It believed will aid researchers better understand current achieving ultimate goal containing disease-causing worldwide.

Language: Английский

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Transducer Technologies for Biosensors and Their Wearable Applications

Biosensors, Journal Year: 2022, Volume and Issue: 12(6), P. 385 - 385

Published: June 2, 2022

The development of new biosensor technologies and their active use as wearable devices have offered mobility flexibility to conventional western medicine personal fitness tracking. In the biosensors, transducers stand out main elements converting signals sourced from a biological event into detectable output. Combined with suitable bio-receptors miniaturization readout electronics, functionality design play key role in construction for health control. Ever-growing research industrial interest transducer point-of-care (POC) bio-detection gained tremendous acceleration by pandemic-induced digital transformation. this article, we provide comprehensive review biosensors applications that empower users tracking biomarkers parameters.

Language: Английский

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Microfluidics-based strategies for molecular diagnostics of infectious diseases

Military Medical Research, Journal Year: 2022, Volume and Issue: 9(1)

Published: March 18, 2022

Abstract Traditional diagnostic strategies for infectious disease detection require benchtop instruments that are inappropriate point-of-care testing (POCT). Emerging microfluidics, a highly miniaturized, automatic, and integrated technology, potential substitute traditional methods in performing rapid, low-cost, accurate, on-site diagnoses. Molecular diagnostics widely used microfluidic devices as the most effective approaches pathogen detection. This review summarizes latest advances microfluidics-based molecular diseases from academic perspectives industrial outlooks. First, we introduce typical on-chip nucleic acid processes, including sample preprocessing, amplification, signal read-out. Then, four categories of platforms compared with respect to features, merits, demerits. We further discuss application digital assay absolute quantification. Both classic recent commercial summarized proof current market status. Finally, propose future directions diagnosis.

Language: Английский

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Nanotechnology-Based Diagnostics for Diseases Prevalent in Developing Countries: Current Advances in Point-of-Care Tests

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(7), P. 1247 - 1247

Published: March 31, 2023

The introduction of point-of-care testing (POCT) has revolutionized medical by allowing for simple tests to be conducted near the patient's care point, rather than being confined a laboratory. This been especially beneficial developing countries with limited infrastructure, where often involves sending specimens off-site and waiting hours or days results. However, development POCT devices challenging, simplicity, accuracy, cost-effectiveness key factors in making these feasible. Nanotechnology played crucial role achieving this goal, not only possible but also masking their complexity. In article, recent developments that benefit from nanotechnology are discussed. Microfluidics lab-on-a-chip technologies highlighted as major drivers testing, particularly infectious disease diagnosis. These enable various bioassays used at point care. article addresses challenges faced technological advances interesting future trends. benefits significant, is shifting towards prevention, early detection, managing chronic conditions. Infectious low-income can lead prompt treatment, preventing infections spreading.

Language: Английский

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Advances and challenges in portable optical biosensors for onsite detection and point-of-care diagnostics

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 173, P. 117640 - 117640

Published: March 8, 2024

Language: Английский

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Noncancerous disease-targeting AIEgens

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(3), P. 1024 - 1067

Published: Jan. 1, 2023

Schematic diagram of noncancerous disease-targeting AIEgens.

Language: Английский

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Nanoplasmonic amplification in microfluidics enables accelerated colorimetric quantification of nucleic acid biomarkers from pathogens

Nature Nanotechnology, Journal Year: 2023, Volume and Issue: 18(8), P. 922 - 932

Published: June 1, 2023

Language: Английский

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SERS-based microdevices for use as in vitro diagnostic biosensors

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(11), P. 5394 - 5427

Published: Jan. 1, 2024

This review explores various microdevices developed for applying SERS technology to in vitro diagnostics and delves into their clinical applications.

Language: Английский

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Fluorescent detection of emerging virus based on nanoparticles: From synthesis to application

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 161, P. 116999 - 116999

Published: Feb. 23, 2023

Language: Английский

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