Pharmaceutics,
Год журнала:
2024,
Номер
16(2), С. 286 - 286
Опубликована: Фев. 17, 2024
Transdermal
drug
delivery
systems
are
rapidly
gaining
prominence
and
have
found
widespread
application
in
the
treatment
of
numerous
diseases.
However,
they
encounter
challenge
a
low
transdermal
absorption
rate.
Microneedles
can
overcome
stratum
corneum
barrier
to
enhance
Among
various
types
microneedles,
nanoparticle-loaded
dissolving
microneedles
(DMNs)
present
unique
combination
advantages,
leveraging
strengths
DMNs
(high
payload,
good
mechanical
properties,
easy
fabrication)
nanocarriers
(satisfactory
solubilization
capacity
controlled
release
profile).
Consequently,
hold
considerable
clinical
potential
precision
medicine
era.
Despite
this
promise,
no
DMN
products
been
approved
thus
far.
The
lack
understanding
regarding
their
vivo
fate
represents
critical
bottleneck
impeding
translation
relevant
products.
This
review
aims
elucidate
current
research
status
elaborate
necessity
investigate
from
diverse
aspects.
Furthermore,
it
offers
insights
into
entry
points
for
DMNs,
aiming
foster
further
advancements
field.
ACS Nano,
Год журнала:
2023,
Номер
17(15), С. 14347 - 14405
Опубликована: Июль 24, 2023
Light
has
profoundly
impacted
modern
medicine
and
healthcare,
with
numerous
luminescent
agents
imaging
techniques
currently
being
used
to
assess
health
treat
diseases.
As
an
emerging
concept
in
luminescence,
aggregation-induced
emission
(AIE)
shown
great
potential
biological
applications
due
its
advantages
terms
of
brightness,
biocompatibility,
photostability,
positive
correlation
concentration.
This
review
provides
a
comprehensive
summary
AIE
luminogens
applied
structure
dynamic
physiological
processes,
disease
diagnosis
treatment,
detection
monitoring
specific
analytes,
followed
by
representative
works.
Discussions
on
critical
issues
perspectives
future
directions
are
also
included.
aims
stimulate
the
interest
researchers
from
different
fields,
including
chemistry,
biology,
materials
science,
medicine,
etc.,
thus
promoting
development
fields
life
health.
Advanced Materials,
Год журнала:
2023,
Номер
36(1)
Опубликована: Авг. 1, 2023
Molecular
fluorophores
emitting
in
the
second
near-infrared
(NIR-II,
1000-1700
nm)
window
with
strong
optical
harvesting
and
high
quantum
yields
hold
great
potential
for
vivo
deep-tissue
bioimaging
high-resolution
biosensing.
Recently,
J-aggregates
are
harnessed
to
engineer
long-wavelength
NIR-II
emitters
show
unique
superiority
tumor
detection,
vessel
mapping,
surgical
navigation,
phototheranostics
due
their
bathochromic-shifted
bands
required
slip-stacked
arrangement
aggregation
state.
However,
despite
preliminary
progress
of
theoretical
study
structure-property
relationships,
further
paradigms
remain
scarce
lack
on
aggregated
fashion.
In
this
effort,
how
utilize
specific
molecular
structure
form
packing
motifs
J-type
exciton
coupling
is
emphatically
elucidated.
First,
several
regulating
strategies
achieve
containing
intermolecular
interactions
external
conditions
positively
summarized
deeply
analyzed.
Then,
recent
reports
theranostics
systematically
provide
a
clear
reference
direction
promoting
development
organic
fluorophores.
Eventually,
prospective
efforts
ameliorating
clinical
practices
outlined.
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(32), С. 17689 - 17699
Опубликована: Авг. 8, 2023
Covalent
organic
frameworks
(COFs)
have
emerged
as
a
promising
class
of
crystalline
porous
materials
for
cancer
phototherapy,
due
to
their
exceptional
characteristics,
including
light
absorption,
biocompatibility,
and
photostability.
However,
the
aggregation-caused
quenching
effect
apoptosis
resistance
often
limit
therapeutic
efficacy.
Herein,
we
demonstrated
first
time
that
linking
luminogens
with
aggregation-induced
emission
(AIEgens)
into
COF
networks
via
vinyl
linkages
was
an
effective
strategy
construct
nonmetallic
pyroptosis
inducers
boosting
antitumor
immunity.
Mechanistic
investigations
revealed
formation
linkage
in
AIE
endowed
it
not
only
high
brightness
but
also
strong
absorption
ability,
long
lifetime,
quantum
yield
favor
generation
reactive
oxygen
species
eliciting
pyroptosis.
In
addition,
synergized
system
αPD-1
effectively
eradicated
primary
distant
tumors
inhibited
tumor
recurrence
metastasis
bilateral
4T1
model.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(26)
Опубликована: Фев. 25, 2024
Abstract
Bacterial
infection
at
wound
sites
can
easily
induce
robust
inflammation.
M1
macrophages
cause
cascade
inflammatory
reactions
to
mediate
a
vicious
inflammation
cycle.
Meanwhile,
the
hypoxia
situation
further
aggravates
destruction
and
contraction
of
blood
vessels
in
microenvironment,
therefore,
hindering
infected
healing
process.
Here,
thermosensitive
hydrogel
is
reported
solve
above
challenges
by
eliminating
bacteria
based
on
photothermal
effect,
regulating
immune
providing
oxygen
(O
2
).
In
vitro
vivo
experiments
confirmed
that
has
great
O
‐producing
properties.
Based
excellent
properties
AIEgens,
good
bactericidal
effect
against
S.
aureus
(100%)
E.
coli
(98.85%).
The
RNA‐sequencing
revealed
Cur@AIE@MnO
/gel
interfere
with
metabolic
process
genetic
material
repair
impact
proliferation
biofilm
dispersal,
thus
achieving
anti‐bacterial
efficacy.
Moreover,
also
up‐regulate
anti‐inflammatory
genes,
down‐regulate
pro‐inflammatory
genes
macrophages,
facilitate
promotion
macrophage
polarization
from
M2
relieve
therapeutic
show
this
accelerated
wound‐healing
Therefore,
work
may
open
new
avenues
for
development
novel
dressings
bacterial‐infected
wounds.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Янв. 24, 2024
Abstract
Toxic
amyloid-beta
(Aβ)
plaque
and
harmful
inflammation
are
two
leading
symptoms
of
Alzheimer’s
disease
(AD).
However,
precise
AD
therapy
is
unrealizable
due
to
the
lack
dual-targeting
function,
poor
BBB
penetration,
low
imaging
sensitivity.
Here,
we
design
a
near-infrared-II
aggregation-induced
emission
(AIE)
nanotheranostic
for
therapy.
The
anti-quenching
at
1350
nm
accurately
monitors
in
vivo
penetration
specifically
binding
with
plaques.
Triggered
by
reactive
oxygen
species
(ROS),
encapsulated
therapeutic-type
AIE
molecules
controllably
released
activate
self-enhanced
program.
One
inhibits
Aβ
fibrils
formation,
degrades
fibrils,
prevents
reaggregation
via
multi-competitive
interactions
that
verified
computational
analysis,
which
further
alleviates
inflammation.
Another
effectively
scavenges
ROS
remodel
cerebral
redox
balance
enhances
effect,
together
reversing
neurotoxicity
achieving
effective
behavioral
cognitive
improvements
female
mice
model.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(26)
Опубликована: Апрель 19, 2024
The
second
near-infrared
(NIR-II,
1000-1700
nm)
light-activated
organic
photothermal
agent
that
synchronously
enables
satisfying
NIR-II
fluorescence
imaging
is
highly
warranted
yet
rather
challenging
on
the
basis
of
overwhelming
nonradiative
decay.
Herein,
such
an
agent,
namely
TPABT-TD,
was
tactfully
designed
and
constructed
via
employing
benzo[c]thiophene
moiety
as
bulky
electron
donor/π-bridge
tailoring
peripheral
molecular
rotors.
Benefitting
from
its
high
donor-acceptor
strength
finely
modulated
intramolecular
motion,
TPABT-TD
simultaneously
exhibits
ultralong
absorption
in
region,
intense
emission
NIR-IIa
(1300-1500
region
nanoaggregates,
conversion
upon
1064
nm
laser
irradiation.
Those
intrinsic
advantages
endow
nanoparticles
with
prominent
fluorescence/photoacoustic/photothermal
trimodal
imaging-guided
therapy
against
orthotopic
4T1
breast
tumor
negligible
adverse
effect.
Chemical Reviews,
Год журнала:
2024,
Номер
124(20), С. 11242 - 11347
Опубликована: Окт. 9, 2024
Biopsy,
including
tissue
and
liquid
biopsy,
offers
comprehensive
real-time
physiological
pathological
information
for
disease
detection,
diagnosis,
monitoring.
Fluorescent
probes
are
frequently
selected
to
obtain
adequate
on
processes
in
a
rapid
minimally
invasive
manner
based
their
advantages
biopsy.
However,
conventional
fluorescent
have
been
found
show
aggregation-caused
quenching
(ACQ)
properties,
impeding
greater
progresses
this
area.
Since
the
discovery
of
aggregation-induced
emission
luminogen
(AIEgen)
promoted
advancements
molecular
bionanomaterials
owing
unique
high
quantum
yield
(QY)
signal-to-noise
ratio
(SNR),
TrAC Trends in Analytical Chemistry,
Год журнала:
2023,
Номер
167, С. 117252 - 117252
Опубликована: Авг. 25, 2023
Fluorescent
biosensors
are
powerful
analytical
tools
that
have
been
widely
employed
in
a
range
of
vitro
and
vivo
biomedical
applications.
However,
traditional
fluorophores
exhibit
aggregation-caused
quenching
(ACQs)
effects
hinder
their
use
the
development
more
advanced
fluorescent
biosensors.
The
discovery
by
Prof.
Ben
Zhong
Tang
aggregation-induced
emission
(AIE)
luminogen
(AIEgen)
opposite
to
those
impacted
ACQ
provides
unique
opportunities
for
design
novel
"turn-on"
These
AIEgens
thus
attracted
extensive
interest
from
researchers
seeking
leverage
properties
produce
effective
biosensing
molecules,
strategies,
associated
A
wide
array
with
structures,
functional
groups,
optical
properties,
applications
developed
recent
years.
In
present
review,
we
provide
comprehensive
overview
advances
field
AIEgen-based
biosensor
discuss
future
clinical
prospects
these
molecules.
Through
discussions,
hope
strong
evidence-based
foundation
further
efforts
aimed
at
producing
increasingly
